Transient loss of consciousness and syncope in children and young people: What you need to know

Archives of Disease in Childhood: Education and Practice Edition

Volumn 95, Issue 3, 2010, Pages 66-72

  Martin, K ^a   Bates, G ^b   Whitehouse, William P ^a,c  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b London Huntercombe Manor Hospital   (United Kingdom)

^c NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FLUDROCORTISONE; GLYCOPYRRONIUM BROMIDE; MIDODRINE; SODIUM CHLORIDE;

BLOOD INJURY PHOBIA; BLURRED VISION; BRAIN BLOOD FLOW; BRAIN PERFUSION; COLLAPSE; CONSCIOUSNESS DISORDER; DIZZINESS; DRUG EFFICACY; DRUG SAFETY; ELECTROCARDIOGRAM; FLUID INTAKE; GROUPS BY AGE; HEART FUNCTION; HEART PACING; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN SUPPLY; PHOBIA; PRIORITY JOURNAL; REVIEW; SEIZURE; SYNCOPE; TACHYCARDIA; VIDEORECORDING;

ADOLESCENT; AGE DISTRIBUTION; CHILD; CHRONIC DISEASE; DIAGNOSIS, DIFFERENTIAL; ELECTROCARDIOGRAPHY; ELECTROENCEPHALOGRAPHY; FEMALE; HEART DISEASES; HUMANS; HYPOXIA, BRAIN; INCIDENCE; MALE; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; ORTHOSTATIC INTOLERANCE; POSTURE; REFLEX; SEIZURES; SEX DISTRIBUTION; SYNCOPE; SYNDROME; TACHYCARDIA; TIME FACTORS;

EID: 77953751730     PISSN: 17430585     EISSN: 17430593     Source Type: Journal    
DOI: 10.1136/adc.2007.121103     Document Type: Review

References (48)

1. Brignole M, Alboni P, Benditt DG, et al. Guidelines on management (diagnosis and treatment) of syncope - update 2004. Europace 2004;6:467-537.
2. Hainsworth R. Pathophysiology of syncope. Clin Auton Res 2004;14:18-24.
3. Driscoll DJ, Jacobsen SJ, Porter CJ, et al. Syncope in children and adolescents. J Am Coll Cardiol 1997;29:1039-45.
4. Lewis DA, Dhala A. Syncope in the pediatric patient. The cardiologist's perspective. Pediatr Clin North Am 1999;46:205-19. (Pubitemid 29177696)
5. Stephenson JBP. Fits and faints. London, UK: Mac Keith Press, 1990.
6. Horrocks IA, Nechay A, Stephenson JB, et al. Anoxic-epileptic seizures: observational study of epileptic seizures induced by syncopes. Arch Dis Child 2005;90:1283-7. (Pubitemid 41736320)
7. Gastaut H. Syncopes: generalised anoxic cerebral seizures. In: Handbook of clinical neurology, vol 15: the epilepsies. Vinken PJ, Bruyn GW, eds. Amsterdam: North-Holland Publishing, 1970.
8. Stewart JM. Orthostatic intolerance in pediatrics. J Pediatr 2002;140:404-11.
9. Stewart JM, Gewitz MH, Weldon A, et al. Patterns of orthostatic intolerance: the orthostatic tachycardia syndrome and adolescent chronic fatigue. J Pediatr 1999;135:218-25. (Pubitemid 30180538)
10. Stewart JM. Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS). J Pediatr 2004;145:725-30.
11. Wieling W. Standing, orthostatic stress and autonomic function. In: Bannister R, Mathias C. Autonomic failure: a textbook of clinical disorders of the autonomic nervous system. Oxford, UK: Oxford University Press, 1992:308-20.
12. Stephenson JB. Reflex anoxic seizures ('white breath-holding'): nonepileptic vagal attacks. Arch Dis Child 1978;53:193-200.
13. Lombroso CT, Lerman P. Breathholding spells (cyanotic and pallid infantile syncope). Pediatrics 1967;39:563-81.
14. DiMario FJ Jr. Prospective study of children with cyanotic and pallid breath-holding spells. Pediatrics 2001;107:265-9.
15. Joensen P. Prevalence, incidence, and classification of epilepsy in the Faroes. Acta Neurol Scand 1986;74:150-5. (Pubitemid 16016613)
16. Zaidi A, Clough P, Cooper P, et al. Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause. J Am Coll Cardiol 2000;36:181-4. (Pubitemid 30466131)
17. Marks I. Blood-injury phobia: a review. Am J Psychiatry 1988;145:1207-13.
18. Ost LG, Lindahl IL, Sterner U, et al. Exposure in vivo vs applied relaxation in the treatment of blood phobia. Behav Res Ther 1984;22:205-16. (Pubitemid 14076166)
19. Stephenson JBP. Vagocardiac syncope and reflex anoxic seizures. In Fits and faints: clinics in developmental medicine 109. Oxford, UK: MacKeith Press, Blackwell, 1990:83-108.
20. Connolly J, Hallam RS, Marks IM. Selective association of fainting with blood-injury-illness fear. Behav Ther 1976;7:8-13.
21. Camfield PR, Camfield CS. Syncope in childhood: a case control clinical study of the familial tendency to faint. Can J Neurol Sci 1990;17:306-8.
22. Mathias CJ, Deguchi K, Bleasdale-Barr K, et al. Frequency of family history in vasovagal syncope. Lancet 1998;352:33-4. (Pubitemid 28306568)
23. DiMario FJ Jr, Sarfarazi M. Family pedigree analysis of children with severe breath-holding spells. J Pediatr 1997;130:647-51.
24. Kaufman H, Wieling W. Syncope: a clinically guided diagnostic algorithm. Clin Auton Res 2005;14:87-90.
25. Mazzuca M, Thomas P. Self-induced stretch syncope of adolescence: a video-EEG documentation. Epileptic Disord 2007;9:413-17.
26. Sturzenegger M, Newell DW, Douville CM, et al. Transcranial Doppler and angiographic findings in adolescent stretch syncope. J Neurol Neurosurg Psychiatr 1995;58:367-70.
27. Kapoor WN. Evaluation and outcome of patients with syncope. Medicine (Baltimore) 1990;69:160-75.
28. Brignole M, Menozzi C, Del Rosso A, et al. New classification of haemodynamics of vasovagal syncope: beyond the VASIS classification. Analysis of the pre-syncopal phase of the tilt test without and with nitroglycerin challenge. Vasovagal Syncope International Study. Europace 2000;2:66-76.
29. DIX MR, Hallpike CS. The pathology, symptomatology and diagnosis of certain common disorders of the vestibular system. Ann Otol Rhinol Laryngol 1952;61:987-1016.
30. Sheth RD, Bodensteiner JB. Effective utilization of home-video recordings for the evaluation of paroxysmal events in pediatrics. Clin Pediatr (Phila) 1994;33:578-82.
31. Brignole M, Alboni P, Benditt DG, et al.; Task Force on Syncope, European Society of Cardiology. Guidelines on management (diagnosis and treatment) of syncope - update 2004. Europace 2004;6:467-537.
32. McLeod KA. Syncope in childhood. Arch Dis Child 2003;88:350-3.
33. Day SC, Cook EF, Funkenstein H, et al. Evaluation and outcome of emergency room patients with transient loss of consciousness. Am J Med 1982;73:15-23.
34. Saul JP. Syncope: etiology, management, and when to refer. J S C Med Assoc 1999;95:385-7.
35. Stephenson JBP, McLeod KA. Reflex anoxic seizures. In: Advances in paediatrics. 2001:1-17.
36. Kenny RA, O'Shea D, Parry SW. The Newcastle protocols for head-up tilt table testing in the diagnosis of vasovagal syncope, carotid sinus hypersensitivity, and related disorders. Heart 2000;83:564-9. (Pubitemid 30316725)
37. Stephenson JB. Clinical diagnosis of syncopes (including so-called breath-holding spells) without electroencephalography or ocular compression. J Child Neurol 2007;22:502-8.
38. Smith D, Defalla BA, Chadwick DW. The misdiagnosis of epilepsy and the management of refractory epilepsy in a specialist clinic. QJM 1999;92:15-23. (Pubitemid 29034096)
39. Eeg-Olofsson O, Petersén I, Selldén U. The development of the electroencephalogram in normal children from the age of 1 through 15 years. Paroxysmal activity. Neuropadiatrie 1971;2:375-404.
40. King MD, Stephenson JBP. A handbook of neurological investigations in children. London, UK: Mac Keith Press, 2009:35-6.
41. Gospe SM Jr, Gabor AJ. Electroencephalography laboratory diagnosis of prolonged QT interval. Ann Neurol 1990;28:387-90.
42. Krediet CT, van Dijk N, Linzer M, et al. Management of vasovagal syncope: controlling or aborting faints by leg crossing and muscle tensing. Circulation 2002;106:1684-9.
43. Scott WA, Pongiglione G, Bromberg BI, et al. Randomized comparison of atenolol and fludrocortisone acetate in the treatment of pediatric neurally mediated syncope. Am J Cardiol 1995;76:400-2.
44. Madrid AH, Ortega J, Rebollo JG, et al. Lack of efficacy of atenolol for the prevention of neurally mediated syncope in a highly symptomatic population: a prospective, double-blind, randomized and placebo-controlled study. J Am Coll Cardiol 2001;37:554-9.
45. Qingyou Z, Junbao D, Chaoshu T. The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope. J Pediatr 2006;149:777-80. (Pubitemid 44816338)
46. McWilliam RC, Stephenson JB. Atropine treatment of reflex anoxic seizures. Arch Dis Child 1984;59:473-5.
47. Sreeram N, Whitehouse W. Permanent cardiac pacing for reflex anoxic seizure. Arch Dis Child 1996;75:462.
48. McLeod KA, Wilson N, Hewitt J, et al. Cardiac pacing for severe childhood neurally mediated syncope with reflex anoxic seizures. Heart 1999;82:721-5.