Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D

Journal of Biological Chemistry

Volumn 285, Issue 26, 2010, Pages 20006-20014

  Carius, Yvonne ^a,e   Christian, Henning ^a,d   Faust, Annette ^a   Zander, Ulrich ^a,e   Klink, Björn U ^c,e   Kornberger, Petra ^b   Kohring, Gert Wieland ^b   Giffhorn, Friedrich ^b   Scheidig, Axel J ^a,e  

^a UNIVERSITY OF KIEL   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SPECIFICITIES; CHIRAL COMPOUNDS; COFACTORS; DIFFERENT SIZES; DIFFERENT SUBSTRATES; GALACTITOL; HIGH POTENTIAL; MAGNESIUM-ION BINDING; NON-POLAR; PRODUCT YIELDS; RATIONAL DESIGN; REGIOSELECTIVE MODIFICATION; RHODOBACTER SPHAEROIDES; SIDE CHAINS; SOLVENT CONCENTRATION; STRUCTURAL INSIGHTS; SUBSTRATE BINDING; TETRAMERS;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CARBOHYDRATES; CRYSTAL STRUCTURE; DEHYDROGENATION; ENZYMES; MAGNESIUM; ORGANIC ACIDS; SUGAR (SUCROSE);

SUBSTRATES;

ASPARAGINE; GALACTITOL DEHYDROGENASE; LYSINE; MAGNESIUM ION; OXIDOREDUCTASE; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOREACTOR; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PH; PRIORITY JOURNAL; RHODOBACTER SPHAEROIDES; SOLVENT EFFECT; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CARBOHYDRATE METABOLISM; CATALYTIC DOMAIN; CRYSTALLIZATION; KINETICS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAD; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RHODOBACTER SPHAEROIDES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SUGAR ALCOHOL DEHYDROGENASES; X-RAY DIFFRACTION;

RHODOBACTER SPHAEROIDES;

EID: 77953748783     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.113738     Document Type: Article

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