Mutant A1555G mitochondrial 12S rRNA and aminoglycoside susceptibility

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 7, 2010, Pages 3073-3074

  Böttger, Erik C ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; MITOCHONDRIAL RNA; RIBOSOME RNA; STREPTOMYCIN; MITOCHONDRIAL DNA;

ANTIBIOTIC SENSITIVITY; CHEMICAL MODIFICATION; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; ESCHERICHIA COLI; HUMAN; LETTER; NONHUMAN; PRIORITY JOURNAL; RIBOSOME; RNA SEQUENCE; STOICHIOMETRY; CHEMICALLY INDUCED; GENETICS; HEARING IMPAIRMENT; MUTATION;

AMINOGLYCOSIDES; DEAFNESS; DNA, MITOCHONDRIAL; HUMANS; MUTATION; RNA, RIBOSOMAL;

EID: 77953742045     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01819-09     Document Type: Letter

References (15)

1. Carter, A. P., W. M. Clemons, D. E. Brodersen, R. J. Morgan-Warren, B. T. Wimberly, and V. Ramakrishnan. 2000. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407:340-348.
2. De Stasio, E. A., and A. E. Dahlberg. 1990. Effects of mutagenesis of a conserved base-paired site near the decoding region of Escherichia coli 16 S ribosomal RNA. J. Mol. Biol. 212:127-132.
3. De Stasio, E. A., D. Moazed, H. F. Noller, and A. E. Dahlberg. 1989. Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions. EMBO J. 8:1213-1216.
4. François, B., R. J. M. Russell, J. B. Murray, F. Aboul-ela, B. Masquida, Q. Vicens, and E. Westhof. 2005. Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. Nucleic Acids Res. 33:5677-5690.
5. Hamasaki, K., and R. R. Rando. 1997. Specific binding of aminoglycosides to a human rRNA construct based on a DNA polymorphism which causes aminoglycoside-induced deafness. Biochemistry 36:12323-12328.
6. Hobbie, S. N., C. M. Bruell, S. Akshay, S. K. Kalapala, D. Shcherbakov, and E. C. Böttger. 2008. Mitochondrial deafness alleles confer misreading of the genetic code. Proc. Natl. Acad. Sci. U. S. A. 105:3244-3249.
7. Hobbie, S. N., S. Akshay, S. K. Kalapala, C. M. Bruell, D. Sherbakov, and E. C. Böttger. 2008. Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity. Proc. Natl. Acad. Sci. U. S. A. 105:20888-20893.
8. Hobbie, S. N., C. M. Bruell, S. K. Kalapala, S. Akshay, S. Schmidt, P. Pfister, and E. C. Böttger. 2006. A genetic model to investigate drug-target interactions at the ribosomal decoding site. Biochimie 88:1033-1043.
9. Hobbie, S. N., P. Pfister, C. M. Bruell, E. Westhof, and E. C. Böttger. 2005. Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction. Antimicrob. Agents Chemother. 49:5112-5118.
10. Hobbie, S. N., P. Pfister, C. M. Bruell, P. Sander, B. François, E. Westhof, and E. C. Böttger. 2006. Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA. Antimicrob. Agents Chemother. 50:1489-1496.
11. Hobbie, S. N., S. K. Kalapala, S. Akshay, C. M. Bruell, S. Schmidt, S. Dabow, A. Vasella, P. Sander, and E. C. Böttger. 2007. Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria. Nucleic Acids Res. 35:6086-6093.
12. Hutchin, T., I. Haworth, K. Higashi, N. Fischel-Ghodsian, M. Stoneking, N. Saha, C. Arnos, and G. Cortopassi. 1993. A molecular basis for human hypersensitivity of aminoglyscoside antibiotics. Nucleic Acids Res. 21:4174-4179.
13. Neefs, J. M., Y. Van de Peer, P. De Rijk, A. Goris, and R. De Wachter. 1991. Compilation of small ribosomal subunit RNA sequences. Nucleic Acids Res. 19:1987-2018.
14. Pfister, P., S. N. Hobbie, C. M. Bruell, N. Corti, A. Vasella, E. Westhof, and E. C. Böttger. 2005. Mutagenesis of 16S rRNA C1409-G1491 base-pair differentiates between 6′OH and 6′NH3+ aminoglycosides. J. Mol. Biol. 346:467-475.
15. Qian, Y., and M.-X. Guan. 2009. Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation. Antimicrob. Agents Chemother. 53:4612-4618.