Age-related susceptibility to severe malaria associated with galectin-2 in Highland Papuans

Journal of Infectious Diseases

Volumn 202, Issue 1, 2010, Pages 117-124

  Randall, Louise M ^a,b   Kenangalem, Enny ^c   Lampah, Daniel A ^c   Tjitra, Emiliana ^e   Mwaikambo, Esther D ^f   Handojo, Tjandra ^c   Piera, Kim A ^c   Zhao, Zhen Zhen ^a   De Labastida Rivera, Fabian ^a   Zhou, Yonghong ^a   McSweeney, Karli M ^a   Le, Lien ^a   Amante, Fiona H ^a   Haque, Ashraful ^a   Stanley, Amanda C ^a   Woodberry, Tonia ^c   Salwati, Ervi ^e   Granger, Donald L ^h   Hobbs, Maurine R ^h   Price, Ric N ^c,d,g   Weinberg, J Brice ⁱ   Montgomery, Grant W ^a   Anstey, Nicholas M ^c,d   Engwerda, Christian R ^a   more..

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^d ROYAL DARWIN HOSPITAL   (Australia)

^e NATIONAL INSTITUTE OF HEALTH RESEARCH AND DEVELOPMENT   (Indonesia)

^f Herbert Kairuki Memorial University   (Tanzania)

^g CHURCHILL HOSPITAL   (United Kingdom)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

ⁱ DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALECTIN 2; LYMPHOTOXIN; LYMPHOTOXIN RELATED GENE ENCODING GALECTIN 2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ALLELE; ARTICLE; BRAIN MALARIA; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENDEMIC DISEASE; FEMALE; GENE EXPRESSION; HUMAN; INDONESIA; INTRON; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; POPULATION RESEARCH; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CHILD; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; INFANT; MALARIA FALCIPARUM; MIDDLE AGED; PRESCHOOL CHILD;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; GALECTIN 2; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INDONESIA; INFANT; INTRONS; MALARIA, FALCIPARUM; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 77953721831     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/653125     Document Type: Article

References (48)

1. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 2000; 9: S1-90.
2. World Health Organization (WHO). World malaria report 2008. http://www.who.int/malaria/publications/atoz/9789241563697/en/index.html. Accessed 4 May 2010.
3. Dondorp AM, Lee SJ, Faiz MA, et al. The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis 2008; 47: 151-157 (Pubitemid 351920613)
4. Touré FS, Ouwe-Missi-Oukem-Boyer O, Bisvigou U, et al. Apoptosis: a potential triggering mechanism of neurological manifestation in Plasmodium falciparum malaria. Parasite Immunol 2008; 30: 47-51.
5. Carlson J, Helmby H, Hill AV, Brewster D, Greenwood BM, Wahlgren M. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. Lancet 1990; 336: 1457-1460
6. Greenwood B, Marsh K, Snow R. Why do some African children develop severe malaria? Parasitol Today 1991; 7: 277-281
7. Hill AV, Jepson A, Plebanski M, Gilbert SC. Genetic analysis of hostparasite coevolution in human malaria. Philos Trans R Soc Lond B Biol Sci 1997; 352: 1317-1325 (Pubitemid 27434096)
8. Grau GE, Fajardo LF, Piguet PF, Allet B, Lambert PH, Vassalli P. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 1987; 237: 1210-1212
9. Engwerda CR, Mynott TL, Sawhney S, De Souza JB, Bickle QD, Kaye PM. Locally up-regulated lymphotoxin α, not systemic tumor necrosis factor α, is the principle mediator of murine cerebral malaria. J Exp Med 2002; 195: 1371-1377
10. Grau GE, Piguet PF, Vassalli P, Lambert PH. Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data. Immunol Rev 1989; 112: 49-70. (Pubitemid 20048807)
11. Kern P, Hemmer CJ, Van Damme J, Gruss HJ, Dietrich M. Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria. Am J Med 1989; 87: 139-143
12. Kwiatkowski D. Tumour necrosis factor, fever and fatality in falciparum malaria. Immunol Lett 1990; 25: 213-216 (Pubitemid 20260871)
13. Clark IA, Gray KM, Rockett EJ, et al. Increased lymphotoxin in human malarial serum, and the ability of this cytokine to increase plasma interleukin-6 and cause hypoglycaemia in mice: implications for malarial pathology. Trans R Soc Trop Med Hyg 1992; 86: 602-607
14. Ozaki K, Inoue K, Sato H, et al. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. Nature 2004; 429: 72-75 (Pubitemid 38620552)
15. Marchiafava E, Bignami A. On summer-autumnal fever. London: New Sydenham Society, 1894.
16. MacPherson GG, Warrell MJ, White NJ, Looareesuwan S, Warrell DA. Human cerebral malaria: a quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol 1985; 119: 385-401.
17. Turner GD, Morrison H, Jones M, et al. An immunohistochemical study of the pathology of fatal malaria: evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration. Am J Pathol 1994; 145: 1057-1069 (Pubitemid 24345654)
18. Clark IA, Awburn MM, Whitten RO, et al. Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children. Malar J 2003; 2: 6.
19. Taylor TE, Fu WJ, Carr RA, et al. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med 2004; 10: 143-145
20. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg 2000; 94: S1-90.
21. Wassmer SC, Medana IM, Turner GDH, et al. Fatal cerebral malaria: distinct microvascular pathologies in children and adult patients. Int J Parasitol 2008; 38: S44.
22. Silamut K, Phu NH, Whitty C, et al. A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain. Am J Pathol 1999; 155: 395-410. (Pubitemid 29370390)
23. Anstey NM, Weinberg JB, Hassanali MY, et al. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 1996; 184: 557-567
24. Day NP, Hien TT, Schollaardt T, et al. The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria. J Infect Dis 1999; 180: 1288-1297 (Pubitemid 30070216)
25. Yeo TW, Lampah DA, Gitawati R, et al. Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc Natl Acad Sci U S A 2008; 105: 17097-17102
26. Ratcliff A, Siswantoro H, Kenangalem E, et al. Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia. Trans R Soc Trop Med Hyg 2007; 101: 351-359
27. Karyana M, Burdarm L, Yeung S, et al. Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum. Malar J 2008; 7: 148.
28. Yeo TW, Lampah DA, Gitawati R, et al. Impaired nitric oxide bioavail-ability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. J Exp Med 2007; 204: 2693-2704 (Pubitemid 350044792)
29. 2) promoter haplotypes. Hum Genet 2010; 127: 163-182
30. Zhao ZZ, Nyholt DR, Le L, et al. Genetic variation in tumour necrosis factor and lymphotoxin is not associated with endometriosis in an Australian sample. Hum Reprod 2007; 22: 2389-2397 (Pubitemid 47296602)
31. Broad Institute. Haploview. http://www.broad.mit.edu/mpg/haploview. Accessed 2 May 2010.
32. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265 (Pubitemid 40202029)
33. Mangino M, Braund P, Singh R, et al. LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians. Atherosclerosis 2007; 194: 112-115
34. International HapMap project, http://www.hapmap.org/. Accessed 2 May 2010.
35. Barondes SH, Cooper DN, Gitt MA, Leffler H. Galectins: structure and function of a large family of animal lectins. J Biol Chem 1994; 269: 20, 807-810 (Pubitemid 24978770)
36. Barondes SH, Castronovo V, Cooper DN, et al. Galectins: a family of animal β-galactoside-binding lectins. Cell 1994; 76: 597-598 (Pubitemid 24070645)
37. Leffler H, Carlsson S, Hedlund M, Qian Y, Poirier F. Introduction to galectins. Glycoconj J 2004; 19: 433-440
38. Leffler H. Introduction to galectins. Trends in Glycoscience and Glycotechnology 1997; 9: 9-19.
39. Hsieh SH, Ying NW, Wu MH, et al. Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells. Oncogene 2008; 27: 3746-3753
40. Sturm A, Lensch M, Andre S, et al. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. J Immunol 2004; 173: 3825-3837 (Pubitemid 39280745)
41. Rao SP, Wang Z, Zuberi RI, et al. Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow. J Immunol 2007; 179: 7800-7807
42. Liu SD, Whiting CC, Tomassian T, et al. Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes. Blood 2008; 112: 120-130
43. + regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood 2007; 110: 1550-1558
44. Bruce MC, Donnelly CA, Packer M, et al. Age- and species-specific duration of infection in asymptomatic malaria infections in Papua New Guinea. Parasitology 2000; 121: 247-256
45. Bekessy A, Molineaux L, Storey J. Estimation of incidence and recovery rates of Plasmodium falciparum parasitaemia from longitudinal data. Bull World Health Organ 1976; 54: 685-693
46. Smith T, Beck HP, Kitua A, et al. Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicity. Trans R Soc Trop Med Hyg 1999; 93: 15-20.
47. Baird JK. Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum. Ann Trop Med Parasitol 1998; 92: 367-390
48. Doolan DL, Dobano C, Baird JK. Acquired immunity to malaria. Clin Microbiol Rev 2009; 22: 13-36.