Preparation of macroporous methacrylate-based monoliths for chromatographic applications by the Reactive Gelation Process

Journal of Chromatography A

Volumn 1217, Issue 28, 2010, Pages 4675-4681

  Bechtle, M ^a   Butte A ^b   Storti, G ^c   Morbidelli, M ^a  

^a ETH ZURICH   (Switzerland)

^b LONZA AG   (Switzerland)

^c POLITECNICO DI MILANO   (Italy)

Author keywords

Downstream processing; Monoliths; PMMA; Protein purification; Reactive Gelation

Indexed keywords

ADSORPTION CAPACITIES; CHROMATOGRAPHIC APPLICATION; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC PURIFICATION; COLUMN EFFICIENCY; DOWNSTREAM-PROCESSING; GELATION PROCESS; HIGH EFFICIENCY; HYDROPHOBIC INTERACTIONS; INNOVATIVE APPROACHES; LOW PERMEABILITY; MACROPOROUS MATERIALS; MACROPOROUS METHACRYLATE; MACROPOROUS STRUCTURES; MATERIAL PROPERTY; MONOLITHS; PROTEIN PURIFICATION; SEM; SIZE-EXCLUSION EFFECT;

ADSORPTION; CHROMATOGRAPHIC ANALYSIS; COAGULATION; GELATION; HYDROPHOBICITY; MONOLITHIC INTEGRATED CIRCUITS; PACKED BEDS; POLYMERS; POLYSTYRENES; POROUS MATERIALS; PROTEINS;

PURIFICATION;

METHACRYLIC ACID; POLY(METHYL METHACRYLATE);

ADSORPTION; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; FLOW RATE; GEL PERMEATION CHROMATOGRAPHY; GELATION; HYDRODYNAMICS; HYDROPHOBICITY; ION EXCHANGE; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN PURIFICATION; QUALITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY;

ADSORPTION; AMMONIUM SULFATE; CHROMATOGRAPHY, GEL; DEXTRANS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; METHYLMETHACRYLATES; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; PRESSURE;

EID: 77953705426     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.04.077     Document Type: Article

References (28)

1. Marti N., Quattrini F., Butte A., Morbidelli M. Macromol. Mater. Eng. 2005, 290(4):221.
2. Leonard M. J. Chromatogr. B 1997, 699(1-2):3.
3. Guiochon G. J. Chromatogr. A 2007, 1168:101.
4. Svec F. J. Sep. Sci. 2004, 27(17-18):1419.
5. Okay O. Prog. Polym. Sci. 2000, 25(6):711.
6. Hjerten S., Liao J.L., Zhang R. J. Chromatogr. 1989, 473(1):273.
7. Svec F., Frechet J.M.J. Anal. Chem. 1992, 64(7):820.
8. Vervoort N., Gazil P., Baron G.V., Desmet G. Anal. Chem. 2003, 75(4):843.
9. Peters E.C., Svec F., Frechet J.M.J. Chem. Mater. 1997, 9(8):1898.
10. Lattuada M., Wu H., Sandkuhler P., Sefcik J., Morbidelli M. Chem. Eng. Sci. 2004, 59(8-9):1783.
11. Meakin P. Adv. Colloid Interface Sci. 1988, 28(4):249.
12. Rudin A. The Elements of Polymer Science and Engineering 1999, Academic Press, San Diego. 2nd ed.
13. A. Butte, ISPPP, 2007.
14. Coupek J., Krivakova M., Pokorny S. J. Polym. Sci. Symp. 1973, 42(1):185.
15. Jungbauer A., Hahn R. J. Chromatogr. A 2008, 1184(1-2):62.
16. Alduncin J.A., Forcada J., Asua J.M. Macromolecules 1994, 27(8):2256.
17. Brunauer S., Emmett P.H., Teller E. J. Am. Chem. Soc. 1938, 60:309.
18. Halasz I., Martin K. Angew. Chem. Int. Ed. 1978, 17(12):901.
19. Guiochon G., Golshan Shirazi S., Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography 2006, Elsevier, Amsterdam.
20. Flory P.J. Principles of Polymer Chemistry 1953, Cornell University Press, Ithaca, NY.
21. Vandeemter J.J., Zuiderweg F.J., Klinkenberg A. Chem. Eng. Sci. 1956, 5(6):271.
22. Carta G., Ubiera A.R., Pabst T.M. Chem. Eng. Technol. 2005, 28(11):1252.
23. Hogg R.V., McKean J.W., Craig A.T. Introduction to Mathematical Statistics 2005, Pearson Education, Upper Saddle River, NJ. 6th ed.
24. Lightfoot E.N., Coffman J.L., Lode F., Yuan Q.S., Perkins T.W., Root T.W. J. Chromatogr. A 1997, 760(1):139.
25. Darcy H. Les Fontaines Publiques de a Ville de Dijon 1856, Dalmont, Paris.
26. Forrer N.A., Butte A., Morbidelli M. J. Chromatogr. A 2008, 1214:59.
27. Bernal J.D., Mason J. Nature 1960, 188(4754):910.
28. N. Marti, PhD thesis, ETH Zurich, 2007.