Significance of nm23 immunoexpression in the prognosis of renal cell carcinoma

Journal of International Medical Research

Volumn 38, Issue 2, 2010, Pages 620-624

  Filiz, G ^a   Adim, S ^a   Aytac, B ^a   Akar, E ^a   Vuruskan, H ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Immunohistochemistry; nm23; Prognosis; Renal cell carcinoma

Indexed keywords

NON METASTATIC GENE 23 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; CONTROLLED STUDY; FEMALE; FOLLOW UP; FUHRMAN NUCLEAR GRADE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SURVIVAL TIME; TUMOR SUPPRESSOR GENE;

EID: 77953692852     PISSN: 03000605     EISSN: None     Source Type: Journal    
DOI: 10.1177/147323001003800224     Document Type: Article

References (20)

1. Zubac DP, Bostad L, Seidal T, et al: The prognostic relevance of interactions between venous invasion, lymph node involvement and distant metastases in renal cell carcinoma after radical nephrectomy. BMC Urol 2008; 8: 19.
2. Canfield SE, Kamat AM, Sánchez-Ortiz RF, et al: Renal cell carcinoma with nodal metastases in the absence of distant metastatic disease (clinical stage TxNl-2MO): the impact of aggressive surgical resection on patient outcome.J Urol 2006; 175: 864-869.
3. Steeg PS, Bevilacqua G, Kopper L, et al: Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1998; 80: 200-204.
4. Barnes R, Masood S, Barker E, et al: Low nm23/NDP kinase protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am JPathol 1991; 139: 245-250.
5. Florenes VA, Aamdal S, Myklebost O, et al: Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res 1992; 52: 6088-6091.
6. Ayhan A, Yasui W, Yolozaki H, et al: Reduced expression of nm23 protein is associated with advanced tumor stage and distant metastases in human colorectal carcinomas. Virchows Arch B Cell Pathol 1993; 63: 213-218.
7. Ozeki Y, Takishima K, Mamiya G: Immunohistochemical analysis of nm23/NDP kinase expression in human lung adenocarcinoma: association with tumor progression in Clara cell type. Jpn j Cancer 1994;85:840-846.
8. Nakamori S, Ishikawa O, Ohhigashi H, et al: Expression of nucleoside diphosphate kinase/ nm23 gene product in human pancreatic cancer: an association with lymph node metastasis and tumor invasion. Clin Exp Metastasis 1993; 11: 151-158.
9. Fuhrman SA, Lasky LC, Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982; 6: 655-663.
10. Sobin LH, Wittekind CH: International Union Against Cancer (UICC): TNM Classification of Malignant Tumours, 5th edn. New York: Wiley-Liss, 1997; pp 180-182.
11. Subramanian C, Cotter II MA, Robertson ES: Epstein-Ban vims nuclear protein EBNA 3C interacts with the human metastatic suppressor Nm23-Hl: a molecular link to cancer metastasis. Nat Med 2001; 7: 350-355.
12. Royds JA, Rees RC, Stephenson TJ: nm23-a metastasis suppressor gene? JPathol 1994; 173: 211-212.
13. Lombardi D, Lacombe ML, Paggi MG: nm23: unraveling its biological function in cell differentiation. J Cell Physiol 2000; 182: 144-149.
14. Backer JM, Mendola CB, Kovesdi I, et al: Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis supressor genes NM23-1 and NM23-2. Oncogene 1993; 8: 497-502.
15. Kitamura H: Prognostic biomarkers of renal cell carcinoma: Recent advances. Indian J Urol 2008; 24: 10-15.
16. Escudier B, Eisen T, Stadler WM, et al for the TARGET Study Group: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356: 125-134.
17. Kirkali Z, Yorukoglu K, Ozkara E, et al: Proliferative activity, angiogenesis and nuclear morphometry in renal cell carcinoma. Int J Urol 2001; 8: 697-703.
18. Tsui KH, Shvarts O, Smith RB, et al: Prognostic indicators for renal cell carcinoma: a multivariate analysis of 643 patients using the revised 1997 TNM staging criteria. J Urol 2000; 163: 1090-1095.
19. Park DS, Cho NH, Lee YT, et al: Analysis of nm23 expression as a prognostic parameter in renal cell carcinoma. J Korean Med Sci 1995; 10: 258-262.
20. Kuo JY, Chang KM, Chen KK, et al: Immunoreactivity of nm23-Hl protein in renal cell carcinoma. Anticancer Res 1998; 18: 531-536.