[1,3]Oxazolo[3,2-b][1,2,4]triazoles: a versatile synthesis of a novel heterocycle

Tetrahedron Letters

Volumn 51, Issue 30, 2010, Pages 3907-3909

  Ball, Catherine ^a   Dean, David K ^a   Lorthioir, Olivier ^a   Page, Lee W ^a   Smith, Charlotte L ^a   Watson, Stephen P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC COMPOUND; OXAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE;

ALKYLATION; ARTICLE; CYCLIZATION; MICROWAVE IRRADIATION; ONE POT SYNTHESIS; QUANTUM YIELD; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 77953682844     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.05.100     Document Type: Article

References (6)

1. Pitt W.R., Parry D.M., Perry B.G., and Groom C.R. J. Med. Chem. 52 (2009) 2952-2963
2. So called 'α effect', see:. Joule J.A., and Mills K. Heterocyclic Chemistry. 4th ed. (2000), Blackwell Publishing p 506
3. Zumbrunn A. Synthesis (1998) 1357-1361
4. X-ray crystallography of 9d confirmed that regioisomer X and not Y was obtained exclusively, as predicted on steric and electronic (α-effect) grounds{A figure is presented}.Crystallographic data (excluding structural factors) for compound 9d have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC 771885. Copies of the data can be obtained free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, (fax: +44 (0)1223 336033 or email: deposit@ccdc.cam.ac.uk).
5. + 138.
6. Libnow S., Wille S., Christiansen A., Hein M., Reinke H., Kockerling M., and Miethchen R. Synthesis (2006) 496-508