Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats

Toxicologic Pathology

Volumn 38, Issue 4, 2010, Pages 598-605

  Takahashi, Miwa ^a   Yoshida, Midori ^a   Inoue, Kaoru ^a   Morikawa, Tomomi ^a   Nishikawa, Akiyoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Children; Food contaminant; Osteolathyrism; Semicarbazide hydrochloride

Indexed keywords

SEMICARBAZIDE; CARBAMYLHYDRAZINE; SEMICARBAZIDE DERIVATIVE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; ARTICULAR CARTILAGE; DEVELOPMENTAL STAGE; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPIPHYSEAL CARTILAGE; FEMALE; HISTOPATHOLOGY; NONHUMAN; OSTEOCHONDRITIS; PRIORITY JOURNAL; RAT; TAIL; TARGET ORGAN; THORACIC AORTA; TIBIA; VASCULAR LESION; ANALYSIS OF VARIANCE; ANIMAL; BODY WEIGHT; BONE DISEASE; CERVICAL SPINE; CHEMICALLY INDUCED; CYTOCHEMISTRY; DRUG EFFECTS; GROWTH PLATE; HINDLIMB; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY; TOXICITY TESTING; VASCULAR DISEASE;

ANIMALIA; RATTUS;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; AORTA, THORACIC; BODY WEIGHT; BONE DISEASES; CERVICAL VERTEBRAE; FEMALE; GROWTH PLATE; HISTOCYTOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; SEMICARBAZIDES; STIFLE; TAIL; TIBIA; TOXICITY TESTS; VASCULAR DISEASES;

EID: 77953682161     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310368979     Document Type: Article

References (30)

1. Abramsson-Zetterberg, L., and Svensson, K. (2005). Semicarbazide is not genotoxic in the flow cytometry-based micronucleus assay in vivo. Toxicol Lett 155, 211-217.
2. Davies, I., and Schofield, J.D. (1980). Connective tissue ageing: the influence of a lathyrogen (beta-aminopropionitrile) on the life span of female C57BL/Icrfat mice. Exp Gerontol 15, 487-494.
3. Davis, E.C. (1995). Elastic lamina growth in the developing mouse aorta. J Histochem Cytochem 43, 1115-1123.
4. Dawson, D.A., Rinaldi, A.C., and P¶ch, G. (2002). Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism. Toxicology 177, 267-284.
5. de la Calle, M.B., and Anklam, E. (2005). Semicarbazide: occurrence in food products and state-of-the-art in analytical methods used for its determination. Anal Bioanal Chem 382, 968-977.
6. de la Fuente del Rey, M. (1986). Teratogenic effect of semicarbazide in Wistar rats. Biol Neonate 49, 150-157.
7. Effkemann, S., and Feldhusen, F., (2004). Triple-quadrupole LC-MS-MS for quantitative determination of nitrofuran metabolites in complex food matrixes. Anal Bioanal Chem 378, 842-844.
8. European Food Safety Authority. (2003). Statement of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact With Food Updating the Advice Available on Semicarbazide in Packaged Foods. Adopted October 1, 2003.
9. European Food Safety Authority. (2005). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food on a request made from the commission related to semicarbazide in food. EFSA Journal 219, 1-36.
10. Food Safety Commission. (2007). The 68th expert committee of veterinary medicines [in Japanese]. http://www.fsc.go.jp/senmon/doubutu/d-dai68/doubutu68- siryou2.pdf
11. Gong, B., Trent, M.B., Srivastava, D., and Boor, P.J. (2006). Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth Defects Res A Clin Mol Teratol 76, 29-38.
12. Haque, A., Hossain, M., Lambein, F., and Bell, E.A. (1997). Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh. Nat Toxins 5, 43-46.
13. Hoenicke, K., Gatermann, R., Hartig, L., Mandix, M., and Otte, S. (2004). Formation of semicarbazide (SEM) in food by hypochlorite treatment: is SEM a specific marker for nitrofurazone abuse ? Food Addit Contam 21, 526-537.
14. Horton, J.A., Bariteau, J.T., Loomis, R.M., Strauss, J.A., and Damron, T.A. (2008). Ontogeny of skeletal maturation in the juvenile rat. Anat Rec (Hoboken) 291, 283-292.
15. Katsuda, S., Waki, H., Yamasaki, M., Nagayama, T., O-Ishi, H., Katahira, K., Machida, N., Hasegawa, M., and Shimizu, T. (2002). Postnatal changes in the rheological properties of the aorta in Sprague-Dawley rats. Exp Anim 51, 83-93.
16. Langford, S.D., Trent, M.B., Balakumaran, A., and Boor, P.J. (1999). Developmental vasculotoxicity associated with inhibition of semicarbazide- sensitive amine oxidase. Toxicol Appl Pharmacol 155, 237-244.
17. Macedo, C.E., Martinez, R.C., Albrechet-Souza, L., Molina, V.A. and Brand£o, M.L. (2007). 5-HT2- and D1-mechanisms of the basolateral nucleus of the amygdala enhance conditioned fear and impair unconditioned fear. Behav Brain Res 177, 100-108.
18. Magyar, K., Mészáros, Z., and Mátyus, P. (2001). Semicarbazide-sensitive amine oxidase: its physiological significance. Pure Appl Chem 73, 1393-1400.
19. Maranghi, F., Tassinari, R., Lagatta, V., Moracci, G., Macrì, C., Eusepi, A., Di Virgilio, A., Scattoni, M.L., and Calamandrei, G. (2009). Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol 47, 472-429.
20. Mercier, N., El Hadri, K., Osborne-Pellegrin, M., Nehme, J., Perret, C., Labat, C., Regnault, V., Lamaziàre, J.M., Challande, P., Lacolley, P., and Fàve, B. (2007). Modifications of arterial phenotype in response to amine oxidase inhibition by semicarbazide. Hypertension 50, 234-241.
21. Morgan, A.J., and Bellamy, D. (1976). Effect of a lathyrogen (aminoacetonitrile hydrochloride) on aortic physiosclerosis and skeletal mineralization in growing rats of different age. Age Ageing 5, 155-163.
22. Nestmann, E.R., Lynch, B.S., Musa-Veloso, K., Goodfellow, G.H., Cheng, E., Haighton, L.A., and Lee-Brotherton, V.M. (2005). Safety assessment and risk-benefit analysis of the use of azodicarbonamide in baby food jar closure technology: putting trace levels of semicarbazide exposure into perspective-a review. Food Addit Contam 22, 875-891.
23. Parodi, S., De Flora, S., Cavanna, M., Pino, A., Robbiano, L., Bennicelli, C., and Brambilla, G. (1981). DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity. Cancer Res 41, 1469-1482.
24. Ramamurti, P., and Taylor, H.E. (1959). Skeletal lesions produced by semicarbazide and experimental analysis of the action of lathyrogenic compounds. J Bone Joint Surg Br 41-B, 590-599.
25. Saari, L., and Peltonen, K. (2004). Novel source of semicarbazide: levels of semicarbazide in cooked crayfish samples determined by LC/MS/MS. Food Addit Contam 21, 825-832.
26. Schwenk, M., Gundert-Remy, U., Heinemeyer, G., Olejniczak, K., Stahlmann, R., Kaufmann, W., Bolt, H.M., Greim, H., von Keutz, E., and Gelbke, H.P. (2003). Children as a sensitive subgroup and their role in regulatory toxicology: DGPT workshop report. Arch Toxicol 77, 2-6.
27. Stadler, R.H., Mottier, P., Guy, P., Gremaud, E., Varga, N., Lalljie, S., Whitaker, R., Kintscher, J., Dudler, V., Read, W.A., and Castle, L. (2004). Semicarbazide is a minor thermal decomposition product of azodicarbonamide used in the gaskets of certain food jars. Analyst 129, 276-281.
28. Steffek, A.J., Verrusio, A.C., and Watkins, C.A. (1972). Cleft palate in rodents after maternal treatment with various lathyrogenic agents. Teratology 5, 33-38.
29. Toth, B., Shumizu, H., and Erickson, J. (1975). Carbamylhydrazine hydrochloride as a lung and blood vessel tumour inducer in Swiss mice. Eur J Cancer 11, 17-22.
30. Weisburger, E.K., Ulland, B.M., Nam, J., Gart, J.J., and Weisburger, J.H. (1981). Carcinogenicity tests of certain environmental and industrial chemicals. J Natl Cancer Inst 67, 75-88.