Acute testis toxicity of bisphenol a diglycidyl ether in Sprague-Dawley rats

Journal of Preventive Medicine and Public Health

Volumn 43, Issue 2, 2010, Pages 131-137

  Yang, Yun Jung ^a   Lee, Shin Young ^a   Kim, Kyung Yong ^a   Hong, Yeon Pyo ^a  

^a Chung Ang University   (South Korea)

Author keywords

Acute toxicity; Bisphenol a diglycidyl ether; Histology; Testis

Indexed keywords

2,2 BIS(4 (2,3 EPOXYPROPYL)PHENYL)PROPANE; 2,2 BIS(4 GLYCIDYLOXYPHENYL)PROPANE; 4,4' ISOPROPYLIDENEDIPHENOL; CORN OIL; ETHER DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE TESTIS TOXICITY; ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; EPIDIDYMIS; ETHERIFICATION; MALE; MICROSCOPY; NONHUMAN; OUTCOME ASSESSMENT; POLYMERIZATION; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SPERMATID; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SPRAGUE DAWLEY RAT; STOMACH LAVAGE; TISSUE HOMOGENATE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEMEN ANALYSIS; SPERMATIDS; SPERMATOGENESIS; TESTIS;

EID: 77953674459     PISSN: 19758375     EISSN: None     Source Type: Journal    
DOI: 10.3961/jpmph.2010.43.2.131     Document Type: Article

References (39)

1. Poole A, van Herwijene P, Weideli H, Thomas MC, Ransbotyn G, Vance C. Review of the toxicology, Human exposure and safety assessment for bisphenol A diglycidyl ether(BADGE). Food Addit Contam 2004; 21:905-919.
2. International Agency for Research on Cancer (IARC). Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide, IARC Monogr Eval Carcinog Risks Hum 1999; 71(Pt 3): 1285-1289.
3. Choi JC, Kyung SH, Lee GT, Lee KH. Simultaneous analysis method of BPA, BPF, BADGE, BFDGE and their degradation products in canned foods and food stimulants by HPLC. Kor J Food Sci Tech 2002; 34(2): 174-179. (Korean).
4. Hammarling L, Gustavsson H, Svensson K, Oskarsson A. Migration of bisphenol A diglycidyl ether (BADGE) and its reaction products in canned foods. Food Addit Contam 2000; 17(1): 937-943.
5. Pulgar R, Olea-Serrano MF, Novillo-Fertrell A, Rivas A, Pazos P, Pedraza V, et al. Determination of bisphenol A and related aromatic compounds released from bis-GMA-based composites and sealants by high performance liquid chromatography. Environ Health Perspect 2000; 108(1): 21-27.
6. Krishnan AV, Stathis P, Permuth SF, Tokes L, Feldman D. Bisphenol A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 1993; 132(6): 2279-2286.
7. Perez P, Pulgar R, Olea-Serrano F, Villalobos M, Rivas A, Metzler M, et al. The estrogenicity of bisphenol a-related diphenylalkanes with various substituents at the central carbon and the hydroxy groups. Environ Health Perspect 1998; 106(3): 167-174.
8. Brotons JA, Olea-Serrano MF, Villalobos M, Pedraza V, Olea N. Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect 1995; 103(6): 608-612.
9. Olea N, Pulgar R, Perez P, Olea-Serrano F, Rivas A, Novillo Fertrell A, et al. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 1996; 104(2): 298-305.
10. Scientific Committee on Food (SCF). Commission of the European Community: 1999 [cited 2009 July 20]. Opinion on bisphenol a diglycidyl ether (BADGE). Available from: URL: http://eceuropa.eu./food/fs/sc/safout28-en.pdf.
11. Nakazawa H, Yamaguchi A, Inoue K, Yamazaki T, Kato K, Yoshimura Y, et al. In vitro assay of hydrolysis and chlorohydroxy derivatives of bisphenol A diglycidyl ether for estrogenic activity. Food Chem Toxicol 2002; 40(12): 1827-1832.
12. Scientific Committee on Food (SCF). Commission of the European Community. 2003. [cited 2009 July 20]. Opinion of the Scientific Committee on Toxicity, Ecotoxicity and the Environment (CSTEE) on "Two Study Reports on Endocrine Disrupters by WRc-NSF and BKH Consulting Engineers". European Commission. 2003. Available from: URL: http://ec.europa.eu/food/fs/sc/sct/out208-en.pdf.
13. Hine CH, Kodama JK, Anderson HH, Simonson DW, Wellington JS. The toxicology of epoxy resins. AMA Arch Ind Health 1958; 17(2): 129-144.
14. Im JU, Yang YJ, Lee TJ, Hong YP. Acute toxicity of administered Bisphenol a diglycidyl ether in male Sprague Dawley rats. Korean J Occup Environ Med 2006; 18(4): 318-326. (Korean).
15. Lamb IV JC. Fundamentals of male reproductive toxicity testing. In: Lamb IV JC, Foster PMD, editors. Physiology and Toxicology of Male Reproduction. San Diego, CA; Academic Press; 1988. p. 137-154.
16. Suter L, Clemann N, Koch E, Bobadilla M, Bechter R. New and traditional approaches for the assessment of testicular toxicity. Reprod Toxicol 1998; 12(1): 3947.
17. st ed. Clearwater FL; Cache River Press; 1990. p. 62-194.
18. Takayama S, Akaike M, Kawashima K, Takahashi M, Kurokawa Y. A collaborative study in Japan on optimal treatment period and parameters for detection of male fertility disorders induced by drugs in rats. Int J Toxicol 1995; 14(4): 266-292.
19. Laiming LL, Creasy DM, Chapin RE, Mann PC, Barlow NJ, Regan KS, et al. Recommended approaches for the evaluation of testicular and epididymal toxicity. Toxicol Pathol 2002; 30(4): 507-520.
20. Stebbins KE, Dryzga MD. Bisphenol A Diglycidyl Ether (BADGE): Subchronic Oral Gavage Toxicity Study In Fischer 344 Rats. Toxicology & Environmental Research and Consulting. Midland, Michigan; The Dow Chemical Company, 2001.
21. Hyoung UJ, Yang YJ, Kwon SK, Yoo JH, Myoung SC, Kim SC, et al. Developmental toxicity by exposure to bisphenol a diglycidyl ether during gestation and lactation period in Sprague-dawley male rat. J Prev Med Public Health 2007; 40(2): 155-161.
22. Cassidy SL, Dix K, Jenkins T. Evaluation of a testicular sperm head counting technique using rats exposed to dimethoxy-ethyl phthalate (DMEP), glycerol a-monochlorohydrin (GMCH), epichlorohydrin (ECH), formaldehyde (FA), or methyl metanesulphonate (MMS). Arch Toxicol 1983; 53(1): 71-78.
23. Wyrobek AJ, Gordon LA, Burkhart JG, Francis MW, Kapp RW Jr, Letz G, et al. An evaluation of mouse sperm morphology test and other sperm tests in non human mammals. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat Res 1983; 115(1): 1-72.
24. Narayana K, D'Souza UJ, Seetharama Rao KP. Ribavirin-induced sperm shape abnormalities in Wistar rat. Mutat Res 2002; 513(1-2): 193-196.
25. Tramer F, Rocco F, Micali F, Samdri G, Panfili E. Antioxidant systems in rat epididymal spermatozoa. Biol Reprod 1998; 59(4): 753-758.
26. Smith JA, Masters RE, Dawe IS. A Study of the Effect of TK 10490 on the Reproductive Function of One Generation in the Rat. Unpublished Report of Ciba-Geigy Ltd. Huntington Research Centre Report CB451/881081. 1989.
27. Hanley TR, Hagler AR, Sullivan VD, Stebbins KE. DGEBPA: Two Generation Oral Gavage Study in Sprague-Dawley Rats. Unpublished Report of the DOW Chemical Company. 1996.
28. Smith JA, Masters RE, Dawe IS. A Study of the Effect of TK 10490 on Pregnancy of the Rat. Unpublished Report of Ciba-Geigy Ltd. Huntington Research Centre Report CB442/87641.1988.
29. Breslin WJ, Kiik HD, Johnson KA. Teratogenic evaluation of diglycidyl ether of bisphenol A (DGEBPA) in New Zealand white rabbits following dermal exposure. Fundam Appl Toxicol 1988; 10(4): 736-743.
30. Kostoiyz EL, Eick JD, Glaros AG, Judy BM, Welshons WV, Burmaster S, et al. Biocompatibility of hydroxylated metabolites of BISGMA and BFDGE. J Dent Res 2003; 82(5): 367-371.
31. Ahn SW, Nedumaran B, Xie Y, Kim DK, Kim YD, Choi HS. Bisphenol A bis(2, 3-dihydroxypropyl) ether (BADGE.2H20) induces orphan nuclear receptor Nur77 gene expression and increases steroidogenesis in mouse testicular Leydig cells. Mol Cells 2008; 26(1): 74-80.
32. Hanaoka T, Kawamura N, Hara K, Tsugane S. Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents. Occup Environ Med 2002; 59(9): 625-628. (Pubitemid 34983589)
33. Climie IJ, Hutson DH, Stoydin G. Metabolism of epoxy rein component 2, 2-bis(4-(2, 3-epoxypropoxy)phenyl) propane, the diglycidyl ether of bisphenol A (DGEBPA) in the mouse. Part II, Identification of metabolites in urine and faeces following a single oral dose of 14C-DGEBPA. Xenobiotica 1981; 11(6): 401-424. (Pubitemid 11052579)
34. Kissinger C, Skinner MK, Griswold MD. Analysis of Sertoli cell-secreted proteins by two-dimensional gel electrophoresis. Biol Reprod 1982; 27(1): 233-240. (Pubitemid 12068669)
35. Blaschuk O, Burdzy K, Fritz IB. Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid. J Biol Chem 1983; 258(12): 7714-7720. (Pubitemid 13038010)
36. Ritzen EM. Hansson V and French FS. The Sertoli Cell. Burger H, de Kretser DM, editors. New York: Raven Press; 1981. p. 171-194.
37. McLachlan RI, O'Donnell L, Meachem SJ, Stanton PG, deKretser DM, Pratis K, et al. Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys, and man. Recent Prog Horn Res 2002; 57:149-179.
38. Kwon SK, Yang YJ, Chun YJ, Hong YP. Expression of clusterin on rat epididymis exposed to bisphenol A diglycidyl ether during in utero and lactation. Toxicol Environ Chem 2010; 92(2): 315-325.
39. Han JH, Choi CS, Kim MY, Chun YJ. Differential gene expression by styrene in rat reproductive tissue. J Toxicol Environ Health A 2007; 70(15-16): 1259-1263. (Pubitemid 47124017)