Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine

Veterinary Journal

Volumn 185, Issue 1, 2010, Pages 23-27

  Eckersall, P D ^a   Bell, R ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Acute phase proteins; Biomarkers; C reactive protein; Diagnosis; Haptoglobin; Serum amyloid A

Indexed keywords

ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLYCOPROTEIN; HAPTOGLOBIN; OROSOMUCOID; SERUM AMYLOID A; SERUM AMYLOID A3; UNCLASSIFIED DRUG;

ANIMAL CARE; ANIMAL HEALTH; ARTERITIS; BLOOD ANALYSIS; CAT DISEASE; CATTLE DISEASE; CEREBROSPINAL FLUID EXAMINATION; DOG DISEASE; FARM ANIMAL; HUMAN; INFECTION; INFLAMMATION; MASTITIS; MENINGITIS; NONHUMAN; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; VETERINARY MEDICINE;

ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ANIMAL DISEASES; ANIMALS; ANIMALS, DOMESTIC; BIOLOGICAL MARKERS; CAT DISEASES; CATS; CATTLE; CATTLE DISEASES; DOG DISEASES; DOGS; INFECTION; INFLAMMATION; SPECIES SPECIFICITY;

ANIMALIA; BOS; CANIS FAMILIARIS;

EID: 77953668968     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2010.04.009     Document Type: Review

References (66)

1. Akerstedt M., Waller K.P., Sternesjo A. Haptoglobin and serum amyloid A in relation to the somatic cell count in quarter, cow composite and bulk tank milk samples. Journal of Dairy Research 2007, 74:198-203.
2. Akerstedt M., Waller K.P., Larsen L.B., Forsback L., Sternesjo A. Relationship between haptoglobin and serum amyloid A in milk and milk quality. International Dairy Journal 2008, 18:669-674.
3. Akerstedt M., Waller K.P., Sternesjo A. Haptoglobin and serum amyloid A in bulk tank milk in relation to raw milk quality. Journal of Dairy Research 2009, 76:483-489.
4. Andersson M., Sevelius E. Abnormal microheterogeneity of haptoglobin in serum from dogs with various diseases. Veterinary Record 2001, 148:14-17.
5. Andersson M., Stenstrom M., Vatne M., Sevelius E., Jonsson L. Disease-related variations of the glycosylation of haptoglobin in the dog. Journal of Comparative Pathology 1998, 119:227-238.
6. Bathen-Noethen A., Carlson R., Menzel D., Mischke R., Tipold A. Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis. Journal of Veterinary Internal Medicine 2008, 22:1149-1156.
7. Bayramli G., Ulutas B. Acute phase protein response in dogs with experimentally induced gastric mucosal injury. Veterinary Clinical Pathology 2008, 37:312-316.
8. Caldin M., Tasca S., Carli E., Bianchini S., Furlanello T., Martinez-Subiela S., Ceron J.J. Serum acute phase protein concentrations in dogs with hyperadrenocorticism with and without concurrent inflammatory conditions. Veterinary Clinical Pathology 2009, 38:63-68.
9. Ceron J.J., Eckersall P.D., Martinez-Subiela S. Acute phase proteins in dogs and cats; current knowledge and future perspectives. Veterinary Clinical Pathology 2005, 34:85-99.
10. Correa S.S., Mauldin G.N., Mauldin G.E., Mooney S.C. Serum alpha 1-acid glycoprotein concentration in cats with lymphoma. Journal of the American Animal Hospital Association 2001, 37:153-158.
11. Dabrowski R., Kostro K., Lisiecka U., Szczubial M., Krakowski L. Usefulness of C-reactive protein, serum amyloid A component, and haptoglobin determinations in bitches with pyometra for monitoring early post-ovariohysterectomy complications. Theriogenology 2009, 72:471-476.
12. Duthie S., Eckersall P.D., Addie D.D., Lawrence C.E., Jarrett O. Value of alpha 1-acid glycoprotein in the diagnosis of feline infectious peritonitis. Veterinary Record 1997, 141:299-303.
13. Eckersall P.D., Harvey M.J., Ferguson J., Renton J.P., Nickson D., Boyd J. Acute phase proteins in canine pregnancy (Canis familiaris). Journal of Reproduction and Fertility 1993, 47(Suppl.):159-164.
14. Eckersall P.D., Young F.J., McComb C., Hogarth C.J., Safi S., Weber A., McDonald T., Nolan A.M., Fitzpatrick J.L. Acute phase proteins in serum and milk from dairy cows with clinical mastitis. Veterinary Record 2001, 148:35-41.
15. Eckersall P.D., Young F.J., Nolan A.M., Knight C.H., McComb C., Waterston M.M., Hogarth C.J., Scott E.M., Fitzpatrick J.L. Acute phase proteins in bovine milk in an experimental model of Staphylococcus aureus subclinical mastitis. Journal of Dairy Science 2006, 89:1488-1501.
16. Eckersall P.D., Lawson F.P., Bence L., Waterston M.M., Lang T.L., Donachie W., Fontaine M.C. Acute phase protein response in an experimental model of ovine caseous lymphadenitis. BMC Veterinary Research 2007, 3:35.
17. Gebhardt C., Hirschberger J., Rau S., Arndt G., Krainer K., Schweigert F.J., Brunnberg L., Kaspers B., Kohn B. Use of C-reactive protein to predict outcome in dogs with systemic inflammatory response syndrome or sepsis. Journal of Veterinary Emergency and Critical Care 2009, 19:450-458.
18. Gerardi G., Bernardini D., Elia C.A., Ferrari V., Iob L., Segato S. Use of serum amyloid A and milk amyloid A in the diagnosis of subclinical mastitis in dairy cows. Journal of Dairy Research 2009, 76:411-417.
19. Giordano A., Spagnolo V., Colombo A., Paltrinieri S. Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection. The Veterinary Journal 2004, 167:38-44.
20. Gronlund U., Hulten C., Eckersall P.D., Hogarth C., Waller K.P. Haptoglobin and serum amyloid A in milk and serum during acute and chronic experimentally induced Staphylococcus aureus mastitis. Journal of Dairy Research 2003, 70:379-386.
21. Harvey J.W., West C.L. Prednisolone-induced increases in serum alpha-2-globulin and haptoglobin concentration in dogs. Veterinary Pathology 1987, 24:90-92.
22. Heegaard P.M.H., Godson D.L., Toussaint M.J.M., Tjornehoj K., Larsen L.E., Viuff B., Ronsholt L. The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncytial virus. Veterinary Immunology and Immunopathology 2000, 77:151-159.
23. Hirvonen J., Hietarkopi S., Saloniemi H. Acute phase response in emergency slaughtered cows. Meat Science 1997, 3:249-257.
24. Holm J.L., Rozanski E.A., Freeman L.M., Webster C.R.L. C-reactive protein concentrations in canine acute pancreatitis. Journal of Veterinary Emergency and Critical Care 2004, 14:183-186.
25. Horadagoda A., Eckersall P.D., Hodgson J.C., Gibbs H.A., Moon G.M. Immediate responses in serum TNFa and acute phase protein concentrations to infection with Pasteurella haemolytica A1 in calves. Research in Veterinary Science 1994, 57:129-132.
26. Horadagoda N.U., Knox K.M.G., Gibbs H.A., Reid S.W.J., Horadagoda A., Edwards S.E.R., Eckersall P.D. Acute phase proteins in cattle: discrimination between acute and chronic inflammation. Veterinary Record 1999, 144:437-441.
27. Hori Y., Indou A., Yamaguchi S., Uechi M. The time course of C-reactive protein in a dog suffering acute pancreatitis. Journal of the Japan Veterinary Medical Association 2006, 59:619-622.
28. Jacobsen S., Niewold T.A., Kornalijnslijper E., Toussaint M.J.M., Gruys E. Kinetics of local and systemic isoforms of serum amyloid A in bovine mastitic milk. Veterinary Immunology and Immunopathology 2005, 104:21-31.
29. Jergens A.E., Schreiner C.A., Frank D.E., Niyo Y., Ahrens F.E., Eckersall P.D., Benson T.J., Evans R. A scoring index for disease activity in canine inflammatory bowel disease. Journal of Veterinary Internal Medicine 2003, 17:291-297.
30. Johnson K.H., Sletten K., Hayden D.W., O'Brien T.D., Rossow K.D., Westermark P. AA amyloidosis in Chinese Shar-pei dogs - immunohistochemical and amino-acid-sequence analyses. Amyloid. International Journal of Experimental and Clinical Investigation 1995, 2:92-99.
31. Kajikawa T., Furuta A., Onishi T., Tajima T., Sugii S. Changes in concentrations of serum amyloid A, alpha(1)-acid glycoprotein, haptoglobin and C-reactive protein in feline sera due to induced inflammation and surgery. Journal of Veterinary Medical Science 1999, 68:91-98.
32. Katoh N., Nakagawa H. Detection of haptoglobin in the high-density lipoprotein and the very high-density lipoprotein fractions from sera of calves with experimental pneumonia and cows with naturally occurring fatty liver. Journal of Veterinary Medical Science 1999, 61:119-124.
33. Kjelgaard-Hansen M., Jensen A.L., Houser G.A., Jessen L.R., Kristensen A.T. Use of serum C-reactive protein as an early marker of inflammatory activity in canine type II immune-mediated polyarthritis: case report. Acta Veterinaria Scandinavica 2006, 48:9.
34. Knapp A., Schrodl W., Grevel V., Oechtering G. C-reactive protein (CRP) serum-concentration in dogs with impaired postoperative wound healing. Tierärztliche Praxis Ausgabe Kleintiere Heimtiere 2009, 37:21-27.
35. Lindmark-Mansson H., Branning C., Alden G., Paulsson M. Relationship between somatic cell count, individual leukocyte populations and milk components in bovine udder quarter milk. International Dairy Journal 2006, 16:717-727.
36. Lowrie M., Penderis J., Eckersall P.D., McLaughlin M., Mellor D., Anderson T.J. The role of acute phase proteins in diagnosis and management of steroid-responsive meningitis arteritis in dogs. The Veterinary Journal 2009, 182:125-130.
37. Lowrie M., Penderis J., McLaughlin M., Eckersall P.D., Anderson T.J. Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008). Journal of Veterinary Internal Medicine 2009, 23:862-870.
38. Martinez-Subiela S., Tecles F., Eckersall P.D., Ceron J.J. Serum concentrations of acute phase proteins in dogs with leishmaniasis. Veterinary Record 2002, 150:241-244.
39. Martinez-Subiela S., Ginel P.J., Ceron J.J. Effects of different glucocorticoid treatments on serum acute phase proteins in dogs. Veterinary Record 2004, 154:814-817.
40. McGrotty Y.L., Arteaga A., Knottenbelt C.M., Ramsey I.K., Eckersall P.D. Haptoglobin concentrations in dogs undergoing trilostane treatment for hyperadrenocorticism. Veterinary Clinical Pathology 2005, 34:255-258.
41. Merlo A., Rezende B.C.G., Franchini M.L., Simoes D.M.N., Lucas S.R.R. Serum C-reactive protein concentrations in dogs with multicentric lymphoma undergoing chemotherapy. Journal of the American Veterinary Medical Association 2007, 230:522-526.
42. Merlo A., Rezencle B.C.G., Franchini M.L., Monteiro P.R.G., Lucas S.R.R. Serum amyloid A is not a marker for relapse of multicentric lymphoma in dogs. Veterinary Clinical Pathology 2008, 37:79-85.
43. Mischke R., Waterston M., Eckersall P.D. Changes in C-Reactive protein and haptoglobin in dogs with lymphatic neoplasia. The Veterinary Journal 2007, 174:188-192.
44. Mitchell K.D., Kruth S.A., Wood R.D., Jefferson B. Serum acute phase protein concentrations in dogs with autoimmune hemolytic anaemia. Journal of Veterinary Internal Medicine 2009, 23:585-591.
45. Moyes K., Drackley J., Salak-Johnson J., Morin D., Hope J., Loor J. Dietary-induced negative energy balance has minimal effects on innate immunity during a Streptococcus uberis mastitis challenge in dairy cows during midlactation. Journal of Dairy Science 2009, 92:4301-4316.
46. Murata H., Shimada N., Yoshioka M. Current research on acute phase proteins in veterinary diagnosis: an overview. The Veterinary Journal 2004, 168:28-40.
47. Nakagawa H., Yamamoto O., Oikawa S., Higuchi H., Watanabe A., Katoh N. Detection of serum haptoglobin by enzyme-linked immunosorbent assay in cows with fatty liver. Research in Veterinary Science 1997, 62:137-141.
48. Nielsen B.H., Jacobsen S., Andersen P.H., Niewold T.A., Heegaard P.M. Acute phase protein concentrations in serum and milk from healthy cows, cows with clinical mastitis and cows with extramammary inflammatory conditions. Veterinary Record 2004, 154:361-365.
49. Nielsen L., Toft N., Eckersall P.D., Mellor D.J., Morris J.S. Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma. Journal of Veterinary Internal Medicine 2007, 21:1231-1236.
50. Niewold T.A., Van der Linde-Sipman J., Murphy C., Tooten P.C.J., Gruys E. Familial amyloidosis in cats: Siamese and Abyssinian AA proteins differ in primary sequence and pattern of deposition. Amyloid-Journal of Protein Folding Disorders 1999, 6:205-209.
51. Ohno K., Yokoyama Y., Nakashima K., Setoguchi A., Fujino Y., Tsujimoto H. C-reactive protein concentration in canine idiopathic polyarthritis. Journal of Veterinary Medical Science 2006, 68:1275-1279.
52. Petersen H.H., Nielsen J.P., Heegaard P.M.H. Application of acute phase protein measurement in veterinary clinical chemistry. Veterinary Research 2004, 35:163-187.
53. Planellas M., Bassols A., Siracusa C., Saco Y., Gimenez M., Pato R., Pastor J. Evaluation of serum haptoglobin and C-reactive protein in dogs with mammary tumors. Veterinary Clinical Pathology 2009, 38:348-352.
54. Rush J.E., Lee N.D., Freeman L.M., Brewer B. C-reactive protein concentration in dogs with chronic valvular disease. Journal of Veterinary Internal Medicine 2006, 20:635-639.
55. Saunders A.B., Smith B.E., Fosgate G.T., Suchodolski J.S., Steiner J.M. Cardiac troponin I and C-reactive protein concentrations in dogs with severe pulmonic stenosis before and after balloon valvuloplasty. Journal of Veterinary Cardiology 2009, 11:9-16.
56. Selting K.A., Ogilvie G.K., Lana S.E., Fettman M.J., Mitchener K.L., Hansen R.A., Richardson K.L., Walton J.A., Scherk M.A. Serum alpha 1-acid glycoprotein concentrations in healthy and tumor-bearing cats. Journal of Veterinary Internal Medicine 2000, 14:503-506.
57. Simojoki H., Orro T., Taponen S., Pyorala S. Host response in bovine mastitis experimentally induced with Staphylococcus chromogenes. Veterinary Microbiology 2009, 134:95-99.
58. Suojala L., Orro T., Jarvinen H., Saatsi J., Pyorala S. Acute phase response in two consecutive experimentally induced E. coli intramammary infections in dairy cows. Acta Veterinaria Scandinavica 2008, 50:18.
59. Tecles F., Spiranelli E., Bonfanti U., Ceron J.J., Paltrinieri S. Preliminary studies of serum acute-phase protein concentrations in hematologic and neoplastic diseases of the dog. Journal of Veterinary Internal Medicine 2005, 19:865-870.
60. Tourlomousis P., Eckersall P.D., Waterston M., Buncic S. A comparison of acute phase protein measurements and meat inspection findings in cattle. Foodborne Pathogens and Disease 2004, 1:281-290.
61. Uchida E., Katoh N., Takahashi K. Appearance of haptoglobin in serum from cows at parturition. Journal of Veterinary Medical Science 1993, 55:893-894.
62. Vannucchi C.I., Mirandola R.M., Oliveira C.M. Acute-phase protein profile during gestation and diestrous: proposal for an early pregnancy test in bitches. Animal Reproduction Science 2002, 74:87-99.
63. Veiga A.P.M., Price C.A., de Oliveira S.T., dos Santos A.P., Campos R., Barbosa P.R., Gonzalez F.H.D. Association of canine obesity with reduced serum levels of C-reactive protein. Journal of Veterinary Diagnostic Investigation 2008, 20:224-228.
64. Winter P., Fuchs K., Walshe K., Colditz I.G. Serum amyloid A in the serum and milk of ewes with mastitis induced experimentally with staphylococcus epidermidis. Veterinary Record 2003, 152:558-562.
65. Yule T.D., Roth M.B., Dreier K., Johnson A.F., Palmer-Densmore M., Simmons K., Fanton R. Canine parvovirus vaccine elicits protection from the inflammatory and clinical consequences of the disease. Vaccine 1997, 15:720-729.
66. Zecconi A., Piccinini R., Fiorina S., Cabrini L., Dapra V., Amadori M. Evaluation of interleukin-2 treatment for prevention of intramammary infections in cows after calving. Comparative Immunology Microbiology and Infectious Diseases 2009, 32:439-451.