-
1
-
-
33746730435
-
Indene derivatives: A novel template for peroxosome proliferatoractivated receptor γ (PPARγ) agonists
-
Ahn, J. H., Shin, M. S., Jung, S. H., Kang, S. K., Kim, K. R., Rhee, S. D., Jung, W. H., Yang, S. D., Kim, S. J., Woo, J. R., Lee, J. H., Cheon, H. G., and Kim, S. S., Indene derivatives: A novel template for peroxosome proliferatoractivated receptor γ (PPARγ) agonists. J. Med. Chem., 49, 4781-4784 (2006).
-
(2006)
J. Med. Chem.
, vol.49
, pp. 4781-4784
-
-
Ahn, J.H.1
Shin, M.S.2
Jung, S.H.3
Kang, S.K.4
Kim, K.R.5
Rhee, S.D.6
Jung, W.H.7
Yang, S.D.8
Kim, S.J.9
Woo, J.R.10
Lee, J.H.11
Cheon, H.G.12
Kim, S.S.13
-
2
-
-
0034802130
-
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH2-terminal protein kinase-related cell death pathway
-
Bae, M. A., Pie, J. E., and Song, B. J., Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH2-terminal protein kinase-related cell death pathway. Mol. Pharmacol., 60, 847-856 (2001).
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 847-856
-
-
Bae, M.A.1
Pie, J.E.2
Song, B.J.3
-
3
-
-
0037308871
-
Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells
-
Bae, M. A. and Song, B. J., Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells. Mol. Pharmacol., 63, 401-408 (2003).
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 401-408
-
-
Bae, M.A.1
Song, B.J.2
-
4
-
-
0029887586
-
Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis
-
Baroni, G. S., D'Ambrosio, L., Curto, P., Casini, A., Mancini, R., Jezequel, A. M., and Benedetti, A., Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology, 23, 1189-1199 (1996).
-
(1996)
Hepatology
, vol.23
, pp. 1189-1199
-
-
Baroni, G.S.1
D'Ambrosio, L.2
Curto, P.3
Casini, A.4
Mancini, R.5
Jezequel, A.M.6
Benedetti, A.7
-
5
-
-
0036183630
-
The mechanisms of action of PPARs
-
Berger, J. and Moller, D. E., The mechanisms of action of PPARs. Annu. Rev. Med., 53, 409-435 (2002).
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 409-435
-
-
Berger, J.1
Moller, D.E.2
-
6
-
-
0029119677
-
Human myofibroblast-like cells obtained by outgrowth are representative of the fibrogenic cells in the liver
-
Blazejewski, S., Preaux, A. M., Mallat, A., Brocherion, I., Mavier, P., Dhumeaux, D., Hartmann, D., Schuppan, D., and Rosenbaum, J., Human myofibroblast-like cells obtained by outgrowth are representative of the fibrogenic cells in the liver. Hepatology, 22, 788-797 (1995).
-
(1995)
Hepatology
, vol.22
, pp. 788-797
-
-
Blazejewski, S.1
Preaux, A.M.2
Mallat, A.3
Brocherion, I.4
Mavier, P.5
Dhumeaux, D.6
Hartmann, D.7
Schuppan, D.8
Rosenbaum, J.9
-
7
-
-
0035142629
-
Halofuginone to prevent and treat thioacetamide- induced liver fibrosis in rats
-
Bruck, R., Genina, O., Aeed, H., Alexiev, R., Nagler, A., Avni, Y., and Pines, M., Halofuginone to prevent and treat thioacetamide- induced liver fibrosis in rats. Hepatology, 33, 379-386 (2001).
-
(2001)
Hepatology
, vol.33
, pp. 379-386
-
-
Bruck, R.1
Genina, O.2
Aeed, H.3
Alexiev, R.4
Nagler, A.5
Avni, Y.6
Pines, M.7
-
8
-
-
0346752176
-
15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells
-
Date, M., Fukuchi, K., Morita, S., Takahashi, H., and Ohura, K., 15-Deoxy-delta12,14-prostaglandin J2, a ligand for peroxisome proliferators-activated receptor-gamma, induces apoptosis in human hepatoma cells. Liver Int., 23, 460-466 (2003).
-
(2003)
Liver Int
, vol.23
, pp. 460-466
-
-
Date, M.1
Fukuchi, K.2
Morita, S.3
Takahashi, H.4
Ohura, K.5
-
9
-
-
0037010478
-
Role of peroxisome proliferatoractivated receptor and retinoid X receptor heterodimer in hepatogastroenterological diseases
-
Dubuquoy, L., Dharancy, S., Nutten, S., Petterson, S., Auwerx, J., and Desreumaux, P., Role of peroxisome proliferatoractivated receptor and retinoid X receptor heterodimer in hepatogastroenterological diseases. Lancet, 360, 1410-1418 (2000).
-
(2000)
Lancet
, vol.360
, pp. 1410-1418
-
-
Dubuquoy, L.1
Dharancy, S.2
Nutten, S.3
Petterson, S.4
Auwerx, J.5
Desreumaux, P.6
-
10
-
-
0041430945
-
Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptorgamma pioglitazone
-
Enomoto, N., Takei, Y., Hirose, M., Konno, A., Shibuya, T., Matsuyama, S., Suzuki, S., Kitamura, K. I., and Sato, N., Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptorgamma, pioglitazone. J. Pharmacol. Exp. Ther., 306, 846-854 (2003).
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.306
, pp. 846-854
-
-
Enomoto, N.1
Takei, Y.2
Hirose, M.3
Konno, A.4
Shibuya, T.5
Matsuyama, S.6
Suzuki, S.7
Kitamura, K.I.8
Sato, N.9
-
11
-
-
0034723290
-
Molecular regulation of hepatic fibrosis an integrated cellular response to tissue injury
-
Friedman, S. L., Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem., 275, 2247-2250 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2247-2250
-
-
Friedman, S.L.1
-
12
-
-
0036082703
-
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
-
Galli, A., Crabb, D. W., Ceni, E., Salzano, R., Mello, T., Svegliati-Baroni, G., Ridolfi, F., Trozzi, L., Surrenti, C., and Casini, A., Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology,122, 1924-1940 (2002).
-
(2002)
Gastroenterology
, vol.122
, pp. 1924-1940
-
-
Galli, A.1
Crabb, D.W.2
Ceni, E.3
Salzano, R.4
Mello, T.5
Svegliati-Baroni, G.6
Ridolfi, F.7
Trozzi, L.8
Surrenti, C.9
Casini, A.10
-
13
-
-
0036892387
-
Pirfenidone effectively reverses experimental liver fibrosis
-
Garcia, L., Hernandez, I., Sandoval, A., Salazar, A., Garcia, J., Vera, J., Grijalva, G., Muriel, P., Margolin, S., and Armendariz-Borunda, J., Pirfenidone effectively reverses experimental liver fibrosis. J. Hepatol., 37, 797-805 (2002).
-
(2002)
J. Hepatol.
, vol.37
, pp. 797-805
-
-
Garcia, L.1
Hernandez, I.2
Sandoval, A.3
Salazar, A.4
Garcia, J.5
Vera, J.6
Grijalva, G.7
Muriel, P.8
Margolin, S.9
Armendariz-Borunda, J.10
-
14
-
-
0025990476
-
Tissue distribution quantitation and proliferation kinetics of fatstoring cells in carbon tetrachloride-injured rat liver
-
Geerts, A., Lazou, J. M., De Bleser, P., and Wisse, E., Tissue distribution, quantitation and proliferation kinetics of fatstoring cells in carbon tetrachloride-injured rat liver. Hepatology, 13, 1193-1202 (1991).
-
(1991)
Hepatology
, vol.13
, pp. 1193-1202
-
-
Geerts, A.1
Lazou, J.M.2
De Bleser, P.3
Wisse, E.4
-
15
-
-
0842308111
-
Pioglitazone prevents hepatic steatosis fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
-
Kawaguchi, K., Sakaida, I., Tsuchiya, M., Omori, K., Takami, T., and Okita, K., Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem. Biophys. Res. Commun., 315, 187-195 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.315
, pp. 187-195
-
-
Kawaguchi, K.1
Sakaida, I.2
Tsuchiya, M.3
Omori, K.4
Takami, T.5
Okita, K.6
-
16
-
-
0036086754
-
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride
-
Kon, K., Ikejima, K., Hirose, M., Yoshikawa, M., Enomoto, N., Kitamura, T., Takei, Y., and Sato, N., Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride. Biochem. Biophys. Res. Commun., 291, 55-61 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.291
, pp. 55-61
-
-
Kon, K.1
Ikejima, K.2
Hirose, M.3
Yoshikawa, M.4
Enomoto, N.5
Kitamura, T.6
Takei, Y.7
Sato, N.8
-
17
-
-
0035851123
-
15-Deoxy-δ12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors
-
Li, L., Tao, J., Davaille, J., Feral, C., Mallat, A., Rieusset, J., Vidal, H., and Lotersztajn, S., 15-Deoxy-δ12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J. Biol. Chem., 276, 38152-38158 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38152-38158
-
-
Li, L.1
Tao, J.2
Davaille, J.3
Feral, C.4
Mallat, A.5
Rieusset, J.6
Vidal, H.7
Lotersztajn, S.8
-
18
-
-
0033855572
-
Ligands of peroxisome proliferator-activated receptor g modulate profibrogenic and proinflammatory actions in hepatic stellate cells
-
Marra, F., Efsen, E., Romanelli, R. G., Caligiuri, A., Pastacaldi, S., Batignani, G., Bonacchi, A., Caporale, R., Laffi, G., Pinzani, M., and Gentilini, P., Ligands of peroxisome proliferator-activated receptor g modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology, 119, 466-478 (2000).
-
(2000)
Gastroenterology
, vol.119
, pp. 466-478
-
-
Marra, F.1
Efsen, E.2
Romanelli, R.G.3
Caligiuri, A.4
Pastacaldi, S.5
Batignani, G.6
Bonacchi, A.7
Caporale, R.8
Laffi, G.9
Pinzani, M.10
Gentilini, P.11
-
19
-
-
0025058042
-
Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis
-
Milani, S., Herbst, H., Schuppan, D., Kim, K. Y., Riecken, E. O., and Stein, H., Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis. Gastroenterology, 98, 175-184 (1990).
-
(1990)
Gastroenterology
, vol.98
, pp. 175-184
-
-
Milani, S.1
Herbst, H.2
Schuppan, D.3
Kim, K.Y.4
Riecken, E.O.5
Stein, H.6
-
20
-
-
0034680787
-
Peroxisome proliferator-activated receptors and hepatic stellate cell activation
-
Miyahara, T., Schrum, L., Rippe, R., Xiong, S., Yee, H. F. Jr, Motomura, K., Anania, F. A., Willson, T. M., and Tsukamoto, H., Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J. Biol. Chem., 275, 35715-35722 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35715-35722
-
-
Miyahara, T.1
Schrum, L.2
Rippe, R.3
Xiong, S.4
Yee H.F. Jr5
Motomura, K.6
Anania, F.A.7
Willson, T.M.8
Tsukamoto, H.9
-
21
-
-
0028931265
-
Principles of CDK regulation
-
Morgan, D. O., Principles of CDK regulation. Nature, 374, 131-134 (1996).
-
(1996)
Nature
, vol.374
, pp. 131-134
-
-
Morgan, D.O.1
-
22
-
-
13844289492
-
Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-a
-
Ohata, M., Suzuki, H., Sakamoto, K., Hashimoto, K., Nakajima, H., Yamauchi, M., Hokkyo, K., Yamada, H., and Toda, G., Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-a. Alcohol. Clin. Exp. Res., 28, 139S-144S (2004).
-
(2004)
Alcohol. Clin. Exp. Res.
, vol.28
-
-
Ohata, M.1
Suzuki, H.2
Sakamoto, K.3
Hashimoto, K.4
Nakajima, H.5
Yamauchi, M.6
Hokkyo, K.7
Yamada, H.8
Toda, G.9
-
23
-
-
0030759740
-
Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis.
-
Pines, M., Knopov, V., Genina, O., Lavelin, I., and Nagler, A., Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis. J. Hepatol., 27, 391-398 (1997).
-
(1997)
J. Hepatol.
, vol.27
, pp. 391-398
-
-
Pines, M.1
Knopov, V.2
Genina, O.3
Lavelin, I.4
Nagler, A.5
-
24
-
-
1442355447
-
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
-
Promrat, K., Lutchman, G., Uwaifo, G. I., Freedman, R. J., Soza, A., Heller, T., Doo, E., Ghany, M., Premkumar, A., Park, Y., Liang, T. J., Yanovski, J. A., Kleiner, D. E., and Hoofnagle, J. H., A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology, 39, 188-196 (2004).
-
(2004)
Hepatology
, vol.39
, pp. 188-196
-
-
Promrat, K.1
Lutchman, G.2
Uwaifo, G.I.3
Freedman, R.J.4
Soza, A.5
Heller, T.6
Doo, E.7
Ghany, M.8
Premkumar, A.9
Park, Y.10
Liang, T.J.11
Yanovski, J.A.12
Kleiner, D.E.13
Hoofnagle, J.H.14
-
25
-
-
2542491213
-
Peroxisome proliferatoractivated receptor gamma in diabetes and metabolism
-
Rangwala, S. M. and Lazar, M. A., Peroxisome proliferatoractivated receptor gamma in diabetes and metabolism. Trends Pharmacol. Sci., 25, 331-336 (2004).
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 331-336
-
-
Rangwala, S.M.1
Lazar, M.A.2
-
26
-
-
0036551274
-
Activation of hepatic stellate cells-a key issue in liver fibrosis
-
Reeves, H. L. and Friedman, S. L., Activation of hepatic stellate cells-a key issue in liver fibrosis. Front Biosci., 7, 808-826 (2002).
-
(2002)
Front Biosci
, vol.7
, pp. 808-826
-
-
Reeves, H.L.1
Friedman, S.L.2
-
27
-
-
0029923670
-
The prolyl 4-hydroxylase inhibitor HOE- 077 prevents activation of Ito Cells reducing procollagen gene expression in rat liver fibrosis induced by cholinedeficient L-amino acid-defined diet
-
Sakaida, I., Matsumura, Y., Kubota, M., Kayano, K., Takenaka, K., and Okita, K., The prolyl 4-hydroxylase inhibitor HOE- 077 prevents activation of Ito Cells, reducing procollagen gene expression in rat liver fibrosis induced by cholinedeficient L-amino acid-defined diet. Hepatology, 23, 755-763 (1996).
-
(1996)
Hepatology
, vol.23
, pp. 755-763
-
-
Sakaida, I.1
Matsumura, Y.2
Kubota, M.3
Kayano, K.4
Takenaka, K.5
Okita, K.6
-
28
-
-
0037013201
-
Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands
-
Sato, O., Kuriki, C., Fukui, Y., and Motojima, K., Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands. J. Biol. Chem., 277, 15703-15711 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15703-15711
-
-
Sato, O.1
Kuriki, C.2
Fukui, Y.3
Motojima, K.4
-
29
-
-
0033564697
-
CDK inhibitors: positive and negative regulators of G1 phase progression
-
Sherr, C. J. and Roberts, J. M., CDK inhibitors: positive and negative regulators of G1 phase progression. Genes Dev., 13, 1501-1512 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
30
-
-
0034953519
-
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
-
Tada, S., Nakamuta, M., Enjoji, M., Sugimoto, R., Iwamoto, H., Kato, M., Nakashima, Y., and Nawata, H., Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. Clin Exp. Pharmacol. Physiol., 28, 522-527 (2001).
-
(2001)
Clin Exp. Pharmacol. Physiol.
, vol.28
, pp. 522-527
-
-
Tada, S.1
Nakamuta, M.2
Enjoji, M.3
Sugimoto, R.4
Iwamoto, H.5
Kato, M.6
Nakashima, Y.7
Nawata, H.8
-
31
-
-
0033921113
-
An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro
-
Vogel, S., Piantedosi, R., Frank, J., Lalazar, A., Rockey, D. C., Friedman, S. L., and Blaner, W. S., An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro. J. Lipid Res., 41, 882-893 (2000).
-
(2000)
J. Lipid Res.
, vol.41
, pp. 882-893
-
-
Vogel, S.1
Piantedosi, R.2
Frank, J.3
Lalazar, A.4
Rockey, D.C.5
Friedman, S.L.6
Blaner, W.S.7
-
32
-
-
0035052916
-
Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1
-
Wang, C., Fu, M., D'Amico, M., Albanese, C., Zhou, J. N., Brownlee, M., Lisanti, M. P., Chatterjee, V. K., Lazar, M. A., and Pestell, R. G., Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. Mol. Cell. Biol., 21, 3057-3070 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3057-3070
-
-
Wang, C.1
Fu, M.2
D'Amico, M.3
Albanese, C.4
Zhou, J.N.5
Brownlee, M.6
Lisanti, M.P.7
Chatterjee, V.K.8
Lazar, M.A.9
Pestell, R.G.10
-
33
-
-
0029834440
-
Animal models of liver fibrosis. Scand
-
Wu, J. and Norton, P. A., Animal models of liver fibrosis. Scand. J. Gastroenterol., 31, 1137-1143 (1996).
-
(1996)
J. Gastroenterol.
, vol.31
, pp. 1137-1143
-
-
Wu, J.1
Norton, P.A.2
-
34
-
-
0037663778
-
Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth
-
Xu, J., Fu, Y., and Chen, A., Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am. J. Physiol. Gastrointest. Liver Physiol., 285, 20-30 (2003).
-
(2003)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.285
, pp. 20-30
-
-
Xu, J.1
Fu, Y.2
Chen, A.3
-
35
-
-
0038051538
-
Effect of caffeic acid phenethyl ester on proliferation and apoptosis of hepatic stellate cells in itro
-
Zhao, W. X., Zhao, J., Liang, C. L., Zhao, B., Pang, R. Q., and Pan, X. H., Effect of caffeic acid phenethyl ester on proliferation and apoptosis of hepatic stellate cells in itro. World J. Gastroenterol., 9, 1278-1281 (2003).
-
(2003)
World J. Gastroenterol.
, vol.9
, pp. 1278-1281
-
-
Zhao, W.X.1
Zhao, J.2
Liang, C.L.3
Zhao, B.4
Pang, R.Q.5
Pan, X.H.6
|