A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 89, Issue 3, 2010, Pages 188-200

  Robinson, Joshua F ^a,c,e   Guerrette, Zachariah ^a,c,e   Yu, Xiaozhong ^a,c,e   Hong, Sungwoo ^a,c,e   Faustman, Elaine M ^a,b,c,d,e  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Center for Ecogenetics and Environmental Health   (United States)

^c Institute for Risk Analysis and Risk Communication   (United States)

^d Center on Human Development and Disability   (United States)

^e Center for Child Environmental Health Risks Research   (United States)

Author keywords

Cell cycle; Development neurulation; Gene expression; Metals; Methylmercury; Neural tube defects; Toxicogenomics

Indexed keywords

METHYLMERCURY; METHYLMERCURY DERIVATIVE; WNT PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EMBRYO; FEMALE; GENE EXPRESSION; MALE; MOUSE; MOUSE EMBRYO; NERVOUS SYSTEM DEVELOPMENT; NEURULATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TOXICOGENETICS; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; CLUSTER ANALYSIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PREGNANCY; PROCEDURES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TIME; TOXICITY; TOXICITY TESTING;

ANIMALIA;

ANIMALS; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; CLUSTER ANALYSIS; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; METHYLMERCURY COMPOUNDS; MICE; MICE, INBRED C57BL; NEURULATION; PREGNANCY; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TIME FACTORS; TOXICITY TESTS; WNT PROTEINS;

EID: 77953646021     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20241     Document Type: Article

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