The Protective Effects of Paclitaxel on Platelet Aggregation through the Inhibition of Thromboxane A2 Synthase

Archives of Pharmacal Research

Volumn 33, Issue 3, 2010, Pages 387-394

  Lee, Jung Jin ^a   Yu, Ji Yeon ^b   Lee, Joo Hyung ^a   Zhang, Wei Yun ^a   Kim, Tack Joong ^c   Myung, Chang Seon ^a   Yun, Yeo Pyo ^d  

^a Chungnam National University   (South Korea)

^b Chonbuk National University   (South Korea)

^c Yonsei University Wonju   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

Ca2+ mobilization; Paclitaxel; Platelet aggregation; TXA2 synthase

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; COLLAGEN; CYCLOOXYGENASE 1; PACLITAXEL; PROSTAGLANDIN D2; SEROTONIN; THROMBIN; THROMBOXANE A2; THROMBOXANE SYNTHASE; ANTITHROMBOCYTIC AGENT; CALCIUM; ENZYME INHIBITOR; PHOSPHOLIPASE C GAMMA;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MALE; NONHUMAN; RABBIT; SEROTONIN RELEASE; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; ANIMAL; BLOOD; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; THROMBOCYTE; TIME;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ARACHIDONIC ACID; BLOOD PLATELETS; CALCIUM; COLLAGEN; CYCLOOXYGENASE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; PACLITAXEL; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN D2; RABBITS; SEROTONIN; SIGNAL TRANSDUCTION; THROMBIN; THROMBOXANE A2; THROMBOXANE-A SYNTHASE; TIME FACTORS;

EID: 77953635271     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0307-1     Document Type: Article

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