Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent west nile encephalitis

Bioconjugate Chemistry

Volumn 21, Issue 6, 2010, Pages 1018-1022

  Fischer, Nicholas O ^a   Infante, Ernesto ^b   Ishikawa, Tomohiro ^b,c   Blanchette, Craig D ^a   Bourne, Nigel ^b   Hoeprich, Paul D ^a   Mason, Peter W ^b,d  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c KOBE UNIVERSITY   (Japan)

^d NOVARTIS VACCINES AND DIAGNOSTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; COST EFFECTIVENESS; NICKEL; VACCINES; VIRUSES;

COST EFFECTIVE; ENVELOPE PROTEINS; IMMOBILISATION; IMMUNOGENS; MIMETICS; POLYHISTIDINE; SIMPLE METHOD; SUBUNIT VACCINE; VACCINE DEVELOPMENT; WEST NILE VIRUS;

CHELATION;

ENVELOPE PROTEIN; NANOPARTICLE; NICKEL CHELATING NANOLIPOPROTEIN PARTICLE; POLYHISTIDINE TAG; SUBUNIT VACCINE; UNCLASSIFIED DRUG; WEST NILE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENCY; IMMUNE RESPONSE; INOCULATION; MOUSE; NONHUMAN; PROVOCATION TEST; VACCINATION; VIRUS ENCEPHALITIS; VIRUS ENVELOPE; WEST NILE ENCEPHALITIS; WEST NILE FLAVIVIRUS;

MUS; WEST NILE VIRUS;

EID: 77953630897     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc100083d     Document Type: Article

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