Spontaneous canine gliomas: Overexpression of EGFR, PDGFRα and IGFBP2 demonstrated by tissue microarray immunophenotyping

Journal of Neuro-Oncology

Volumn 98, Issue 1, 2010, Pages 49-55

  Higgins, Robert J ^a   Dickinson, Peter J ^a   Lecouteur, Richard A ^a   Bollen, Andrew W ^b   Wang, Huamin ^c   Wang, Hua ^c   Corely, Linda J ^c   Moore, Lynnette M ^c   Zang, Wei ^c   Fuller, Gregory N ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Canine; EGFR; Glioma; IGFBP2; Immunohistochemistry; PDGFR ; Tissue microarray

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SOMATOMEDIN BINDING PROTEIN 2;

ANAPLASTIC CARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; CANCER CLASSIFICATION; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; GENE OVEREXPRESSION; GLIOMA; IMMUNOCYTOCHEMISTRY; IMMUNOPHENOTYPING; NONHUMAN; OLIGODENDROGLIOMA; PATHOPHYSIOLOGY; TISSUE MICROARRAY;

ANIMALS; BRAIN NEOPLASMS; DOGS; FEMALE; GLIOMA; IMMUNOPHENOTYPING; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; MALE; MICROARRAY ANALYSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA;

EID: 77953616455     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-009-0072-5     Document Type: Article

References (25)

1. Kliehues P, Burger PC, Aldape KD (2007) Glioblastoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavanee WK et al (eds) WHO classification of tumours of the central nervous system. IARC, Lyon, France, pp 33-49
2. TP Fleming A Saxena WC Clark, et al. 1992 Amplification or overexpression of platelet derived growth factor receptors and epidermal growth factor receptor in human glial tumors Cancer Res 52 4550 4553 1:CAS:528: DyaK38XlvV2ht7g%3D 1322795
3. C Haberler E Gelpi C Marosi, et al. 2006 Immunohistochemical analysis of platelet derived growth factor receptor-α,-β, c-kit, c-abl, and arg proteins in glioblastoma: possible implications for patient selection for imatinib mesylate therapy J Neurooncol 76 105 109 10.1007/s11060-005-4570-9 1:CAS:528:DC%2BD28Xis1SgsrY%3D 16205964 (Pubitemid 43125736)
4. F DiRocco RS Carroll J Zhang PM Black 1998 Platelet-derived growth factor and its receptor expression in human oligodendrogliomas Neurosurgery 42 341 346 10.1097/00006123-199802000-00080 1:STN:280:DyaK1c7ktFaruw%3D%3D (Pubitemid 28076794)
5. JS Smith XY Wang Qian Jetal 2000 Amplification of the platelet-derived growth factor receptor-A (PDGFA) gene occurs in oligodendrogliomas with grade IV anaplastic features J Neuropathol Exp Neurol 59 495 503 1:CAS:528: DC%2BD3cXktlWrtbs%3D 10850862
6. AH Shih C Dai X Hu, et al. 2004 Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis Cancer Res 64 4783 4789 10.1158/0008-5472.CAN-03-3831 1:CAS:528:DC%2BD2cXls1Omsb4%3D 15256447 (Pubitemid 38924521)
7. GN Fuller CH Rhee KR Hess, et al. 1999 Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling Cancer Res 59 4228 4232 1:CAS:528:DyaK1MXlvVSmsr8%3D 10485462
8. W Zhang H Wang SW Song GN Fuller 2002 Insulin-like growth factor binding protein 2: gene expression microarrays and the hypothesis-generation paradigm Brain Pathol 12 87 94 1:CAS:528:DC%2BD38XlvVSmt7k%3D 11770904
9. MW Elmlinger MH Deininger BS Schuett, et al. 2001 In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade Endocrinology 142 1652 1658 10.1210/en.142.4.1652 1:CAS:528:DC%2BD3MXitlelsr4%3D 11250947 (Pubitemid 32299696)
10. KL McDonald MG O'Sullivan JF Parkinson, et al. 2007 IQGAP1 and IGFBP2: valuable biomarkers for determining prognosis in glioma patients J Neuropathol Exp Neurol 66 405 417 10.1097/nen.0b013e31804567d7 1:CAS:528: DC%2BD2sXmtVyqtr8%3D 17483698 (Pubitemid 46701323)
11. H Wang H Wang W Shen, et al. 2003 Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes Cancer Res 63 4315 4321 1:CAS:528:DC%2BD3sXmtFekur0%3D 12907597 (Pubitemid 36950996)
12. GK Wang L Hu GN Fuller W Zhang 2006 An interaction between insulin-like growth factor-binding protein 2 (IFGBP2) and integrin α5 is essential for IGFBP2-induced cell mobility J Biol Chem 281 14085 14091 10.1074/jbc.M513686200 1:CAS:528:DC%2BD28XksFeis7g%3D 16569642 (Pubitemid 43848335)
13. SM Dunlap J Celestino H Wang, et al. 2007 Insulin-like growth factor binding protein 2 promotes glioma development and progression PNAS 104 11736 11741 10.1073/pnas.0703145104 1:CAS:528:DC%2BD2sXotVShsb0%3D 17606927 (Pubitemid 47175082)
14. WA Priester N Mantel 1971 Occurrence of tumors in domestic animals. Data from 12 United States and Canadian colleges of veterinary medicine J Natl Cancer Inst 47 1333 1344 1:STN:280:DyaE38%2Fktl2juw%3D%3D 5120412
15. D Lipsitz RJ Higgins GD Kortz, et al. 2003 Glioblastoma multiforme: clinical findings, magnetic resonance imaging and pathology in five dogs Vet Pathol 40 659 669 10.1354/vp.40-6-659 1:STN:280:DC%2BD3srjtVOktw%3D%3D 14608019 (Pubitemid 38393539)
16. G Stoica H-T Kim DG Hall JR Coates 2004 Morphology, immunocytochemistry, and genetic alterations in dog astrocytomas Vet Pathol 41 10 19 10.1354/vp.41-1-10 1:STN:280:DC%2BD2c%2FhvFCisw%3D%3D 14715963 (Pubitemid 38146842)
17. PJ Dickinson B Roberts RJ Higgins, et al. 2006 Expression of tyrosine kinase receptors VEGF-1 (FLT-1), VEGFR-2 (KDR), EGFR-1, PDGFRα and c-Met in canine brain tumors Vet Comp Oncol 4 132 140 10.1111/j.1476-5829.2006.00101.x 1:CAS:528:DC%2BD28Xht1SgtbfI 19754810
18. DN Louis H Ohgaki OD Wiestler, et al. 2007 The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol 114 97 109 10.1007/s00401-007-0243-4 17618441 (Pubitemid 47103521)
19. H Wang H Wang W Zhang GN Fuller 2002 Tissue microarrays: applications in neuropathology research, diagnosis and education Brain Pathol 12 95 107 11770905
20. K Watanabe O Tachibana K Sata Y Yonekawa P Kliehues 1996 Ohaki H overexpression of the EF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas Brain Pathol 6 217 223 10.1111/j.1750-3639.1996.tb00848.x 1:STN:280:DyaK2s%2FhslKlsw%3D%3D 8864278
21. JY Li H Wang S May X Song J Fueyo GN Fuller H Wang 2008 Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas J Neurooncol 88 11 17 10.1007/s11060-008-9529-1 1:CAS:528:DC%2BD1cXms1Orsrg%3D 18246408
22. J Reifenberger G Reifenberger K Ichimura EE Schmidt W Wechsler VP Collins 1996 Epidermal growth factor receptor expression in oligodendroglial tumors Am J Pathol 149 29 35 1:STN:280:DyaK283nsFGntA%3D%3D 8686753
23. RE McLendon CJ Wikstrand MR Matthews R Al-Baradei S Bigner D Bigner 2000 Glioma-associated antigen expression in oligodendroglial neoplasms: tenascin and epidermal growth factor receptor J Histochem Cytochem 48 1103 1110 1:CAS:528:DC%2BD3cXlsFOlsbc%3D 10898803
24. S Robinson M Cohen R Prayson RM Ransohoff N Tabrizi RH Miller 2001 Constitutive expression of growth-related oncogene and its receptor in oligodendrogliomas Neurosurgery 48 864 873 10.1097/00006123-200104000-00035 1:STN:280:DC%2BD3M3ivFSisA%3D%3D 11322447
25. C Dai Y Lyustikman A Shih, et al. 2005 The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats Neoplasia 7 397 406 10.1593/neo.04691 1:CAS:528:DC%2BD2MXkvFeqtLc%3D 15967117 (Pubitemid 40664229)