Pulmonary nodules in workers exposed to urban stressor

Environmental Research

Volumn 110, Issue 5, 2010, Pages 519-525

  Sancini, A ^a   Fioravanti, M ^a   Ciarrocca, M ^a   Palermo, P ^a   Fiaschetti, M ^a   Schifano, M P ^a   Tomei, G ^a   Tomei, F ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

LD CT; Lung cancer; Lung nodules; Traffic police workers; Urban air pollutants

Indexed keywords

BENZENE; NITROGEN DIOXIDE;

ATMOSPHERIC POLLUTION; CANCER; HEALTH RISK; OCCUPATIONAL EXPOSURE; POLICE FORCE; RESPIRATORY DISEASE; SMOKING; URBAN AREA;

ADULT; AGE DISTRIBUTION; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; HIGH RISK BEHAVIOR; HUMAN; ITALY; LUNG LESION; LUNG NODULE; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL HAZARD; PARTICULATE MATTER; POLICE; POLLUTANT; POLLUTION MONITORING; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; STRESS;

AIR POLLUTANTS, OCCUPATIONAL; AIR POLLUTION; BENZENE; CITIES; HUMANS; MIDDLE AGED; NITROGEN DIOXIDE; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; PARTICLE SIZE; PARTICULATE MATTER; SMOKING; SOLITARY PULMONARY NODULE;

ITALY;

EID: 77953616386     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2010.04.001     Document Type: Article

References (78)

1. Barbone F., Bovenzi M., Cavallieri F., Stanta G. Air pollution and lung cancer in Trieste, Italy. Am. J. Epidemiol. 1995, 141(12):1161-1169.
2. Beelen R., Hoek G., van den Brandt P.A., Goldbohm R.A., Fischer P., Schouten L.J., Armstrong B., Brunekreef B. Long-term exposure to traffic-related air pollution and lung cancer risk. Epidemiology 2008, 19(5):702-710.
3. Beeson W.L., Abbey D.A., Knutsen S.F. Long-term concentrations of ambient air pollutants and incident lung cancer in California adults: results from the AHSMOG study. Environ. Health Perspect. 1998, 106:813-823.
4. Belpomme D., Irigaray P., Hardell L., Clapp R., Montagnier L., Epstein S., Sasco A.J. The multitude and diversity of environmental carcinogens. Environ. Res. 2007, 105(3):414-429.
5. Berthoin K., Broeckaert F., Robin M., Haufroid V., De Burbure C., Bernard A. Serum pneumoproteins and biomarkers of exposure to urban air pollution: a cross-sectional comparison of policemen and foresters. Biomarkers 2004, 9(4-5):341-352.
6. Boffetta P. Human cancer from environmental pollutants: the epidemiological evidence. Mutat. Res. 2006, 608(2):157-162.
7. Camiciottoli G., Cavigli E., Grassi L., Diciotti S., Orlandi I., Zappa M., Picozzi G., Pegna A.L., Paci E., Falaschi F., Mascalchi M. Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial. Eur. Radiol. 2009, 19(1):58-66.
8. Carere A., Andreoli C., Galati R., Leopardi P., Marcon F., Rosati M.V., Rossi S., Tomei F., Verdina A., Zijno A., Crebelli R. Biomonitoring of exposure to urban air pollutants: analysis of sister chromatid exchanges and DNA lesions in peripheral lymphocytes of traffic policemen. Mutat. Res. 2002, 518:215-224.
9. Chen T.M., Gokhale J., Shofer S., Kuschner W.G. Outdoor air pollution: particulate matter health effects. Am. J. Med. Sci. 2007, 333(4):235-243.
10. Cohen A.J., Ross Anderson H., Ostro B., Pandey K.D., Krzyzanowski M., Künzli N., Gutschmidt K., Pope A., Romieu I., Samet J.M., Smith K. The global burden of disease due to outdoor air pollution. J. Toxicol. Environ. Health A. 2005, 68(13-14):1301-1307.
11. Coultas D.B., Zumwalt R.E., Black W.C., Sobonya R.E. The epidemiology of interstitial lung diseases. Am. J. Respir. Crit. Care Med. 1994, 150:967-972.
12. Coyle Y.M., Minahjuddin A.T., Hynan L.S., Minna J.D. An ecological study of the association of metal air pollutants with lung cancer incidence in Texas. J. Thorac. Oncol. 2006, 1(7):654-661.
13. Crebelli R., Tomei F., Zijno A., Ghittori S., Imbriani M., Gamberale D., Martini A., Carere A. Exposure to benzene in urban workers: environmental and biological monitoring of traffic police in Rome. Occup. Environ. Med. 2001, 58:165-171.
14. Desai S.R., Hansell D.M., Walker A., MacDonald S.L., Chabat F., Wells A.U. Quantification of emphysema: a composite physiologic index derived from CT estimation of disease extent. Eur. Radiol. 2007, 17:911-918.
15. Diederich S., Lenzen H., Windmann R., Puskas Z., Yelbuz T.M., Henneken S., Klaiber T., Eameri M., Roos N., Peters P.E. Pulmonary nodules: experimental and clinical studies at low-dose CT. Radiology 1999, 213:289-298.
16. Diederich S., Thomas M., Semik M., Lenzen H., Roos N., Weber A., Heindel W., Wormanns D. Screening for early lung cancer with low-dose spiral computed tomography: results of annual follow-up examinations in asymptomatic smokers. Eur. Radiol. 2004, 14(4):691-702.
17. Diederich S., Wormanns D., Semik M., Thomas M., Lenzen H., Roos N., Heindel W. Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers. Radiology 2002, 222(3):773-781.
18. Dockery D.W., Pope C.A., Xu X., Spengler J.D., Ware J.H., Fay M.E., Ferris B.G., Speizer F.E. An association between air pollution and mortality in six US cities. N. Engl. J. Med. 1993, 329:1753-1759.
19. Dragonieri S., Musti M., Izzo C., Esposito L.M., Foschino Barbaro M.P., Resta O., Spanevello A. Sputum induced cellularity in a group of traffic policemen. Sci. Total Environ. 2006, 367(1):433-436.
20. E.P.A., U.S., 1993. Motor vehicle related toxic study. Environmental Protection Agency. Cincinnati (OH). EPA-R-93-005.
21. Faberi, M., Martuzzi, M., Pirrami, F., (Eds.), 2004. Assessing the health impact and social costs of mopeds: feasibility study in Rome. World Health Organization Regional Office for Europe, Copenhagen.
22. Finch G.L., Nikula K.J., Chen B.T., Barr E.B., Chang I.Y., Hobbs C.H. Effect of chronic cigarette smoke exposure on lung clearance of tracer particles inhaled by rats. Fundam. Appl. Toxicol. 1995, 24:76-85.
23. Forastiere F., Perucci C.A., Di Pietro A., Miceli M., Rapiti E., Bargagli A., Borgia P. Mortality among urban policemen in Rome. Am. J. Ind. Med. 1994, 26(6):785-798.
24. Fustinoni S., Buratti M., Giampiccolo R., Colombi A. Biological and environmental monitoring of exposure to airborne benzene and other aromatic hydrocarbons in Milan traffic wardens. Toxicol. Lett. 1995, 77(1-3):387-392.
25. Galati R., Zijno A., Crebelli R., Falasca G., Tomei F., Iecher F., Carta P., Verdina A. Detection of antibodies to the benzo(a)pyrene diol epoxide-DNA adducts in sera from individuals exposed to low doses of polycyclic aromatic hydrocarbons. J. Exp. Clin. Cancer Res. 2001, 20:359-364.
26. Gallus S., Negri E., Boffetta P., McLaughlin J.K., Bosetti C., La Vecchia C. European studies on long-term exposure to ambient particulate matter and lung cancer. Eur. J. Cancer Prev. 2008, 17(3):191-194.
27. Giovagnoli M.R., Alderisio M., Cenci M., Nofroni I., Vecchione A. Carbon and hemosiderin-laden macrophages in sputum of traffic policeman exposed to air pollution. Arch. Environ. Health. 1999, 54(4):284-290.
28. Henschke C.I., McCauley D.I., Yankelevitz D.F., Naidich D.P., McGuinnes G., Miettinen O.S., Libby D.M., Pasmantier M.W., Koizumi J., Altorki N.K., Smith J.P. Early lung cancer action project: overall design and findings from baseline screening. Lancet 1999, 354:99-105.
29. Henschke C.I., Yankelevitz D.F., McCauley D.I., Libby D.M., Pasmantier M.W., Smith J.P. Guidelines for the use of spiral computed tomography in screening for lung cancer. Eur. Respir. J. 2003, 21:45-51.
30. Humphrey L.L., Teutsch S., Johnson M. Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the U.S. preventive service task force. Ann. Intern. Med. 2004, 140:740-753.
31. Ingle S.T., Pachpande B.G., Wagh N.D., Patel V.S., Attarde S.B. Exposure to vehicular pollution and respiratory impairment of traffic policemen in Jalgaon City, India. Ind. Health 2005, 43(4):656-662.
32. Institute for Protection and Environmental Research (I.S.P.R.A.), 2007. Available at: 〈〉 (accessed 18 march 2010). http://www.areeurbane.apat.it/site/it-IT/.
33. International Agency for Research on Cancer-I.A.R.C Monographs on the evaluation of carcinogenic risks to human. Diesel and Gasoline Engine Exhausts and Some Nitroarenes 1989, Vol. 46. IARC, Lyon.
34. International Early Lung Cancer Action Program Investigators (I-ELCAP), Henschke C.I., Yankelevitz D.F., Libby D.M., Pasmantier M.W., Smith J.P., Miettinen O.S. Survival of patients with stage I lung cancer detected on CT screening. N. Engl. J. Med. 2006, 355:1763-1771.
35. Italian National Institute of Statistic (I.S.T.A.T.), 2008. Bilancio demografico anno 2008 e popolazione residente al 31 Dicembre 2006. Comune Roma. Available at 〈〉 (accessed 18 march 2010). http://demo.istat.it/bil2008/index.html.
36. Italian National Institute of Statistic (ISTAT). Cause di morte nella popolazione italiana. 2007. Available at 〈〉 (accessed 18 march 2010). http://www.istat.it/sanita/salute/.
37. Karita K., Yano E., Jinsart W., Boudoung D., Tamura K. Respiratory symptoms and pulmonary function among traffic police in Bangkok, Thailand. Arch. Environ. Health 2001, 56(5):467-470.
38. Katsouyanni K., Pershagen G. Ambient air pollution exposure and cancer. Cancer Causes Control 1997, 8:284-291.
39. Kim Y.M., Harrad S., Harrison R.M. Levels and sources of personal inhalation exposure to volatile organic compounds. Environ. Sci. Technol. 2002, 36(24):5405-5410.
40. Leopardi P., Zijno A., Marcon F., Conti L., Carere A., Verdina A., Galati R., Tomei F., Baccolo T.P., Crebelli R. Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARAC. Environ. Mol. Mutagenesis 2003, 41:126-130.
41. Leung P.L., Harrison R.M. Evaluation of personal exposure to monoaromatic hydrocarbons. Occup. Environ. Med. 1998, 55:249-257.
42. Libby D.M., Smith J.P., Altorki N.K., Pasmantier M.W., Yankelevitz D., Henschke C.I. Managing the small pulmonary nodule discovered by CT. Chest 2004, 125:1522-1529.
43. Maffei F., Hrelia P., Angelini S., Carbone F., Cantelli Forti G., Barbieri A., Sanguinetti G., Mattioli S., Violante F.S. Effects of environmental benzene: micronucleus frequencies and haematological values in traffic police working in an urban area. Mutat. Res. 2005, 583:1-11.
44. Matre A., Soulat J.M., Masclet P., Stoklov M., Marquès M., de Gaudemaris R. Exposure to carcinogenic air pollutants among policemen working close to traffic in an urban area. Scand. J. Work Environ. Health. 2002, 28(6):402-410.
45. 10 and Ozone in 13 Italian cities 2006, World Health Organization-Regional Office for Europe, Copenhagen. M. Martuzzi, F. Mitis, I. Iavarone, M. Serinelli (Eds.).
46. 10 concentrations in nonsmokers. J. Expo. Anal. Environ. Epidemiol. 2000, 10:427-436.
47. Mountain C.F. Revisions in the international system for staging lung cancer. Chest 1997, 111:1710-1717.
48. Mulshine J.L., Sullivan D.C. Lung cancer screening. Engl. J. Med. 2005, 30(352):2714-2720.
49. Nafstad P., Håheim L.L., Oftedal B., Gram F., Holme I., Hjermann I., Leren P. Lung cancer and air pollution: a 27 year follow up of 16 209 Norwegian men. Thorax 2003, 58:1071-1076.
50. Nyberg F., Gustavsson P., Jarup L., Bellander T., Berglind N., Jakobsson R., Pershagen G. Urban air pollution and lung cancer in Stockholm. Epidemiology 2000, 11(5):487-495.
51. Passariello, R. (Ed.), 2005. Radiologia: elementi di tecnologia, fourth ed. Idelson-Gnocchi, Napoli. 28, 336-38.
52. Pisani P., Parkin D.M., Bray F., Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. Int. J. Cancer 1999, 83(1):18-29.
53. Pope C.A., Burnett R.T., Thun M.J., Calle E.E., Krewski D., Ito K., Thurston G.D. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc. 2002, 287:1132-1141.
54. Pukkala E., Martinsen J.I., Lynge E., Gunnarsdottir H.K., Sparén P., Tryggvadottir L., Weiderpass E., Kjaerheim K. Occupation and cancer-follow-up of 15 million people in five Nordic countries. Acta Oncol. 2009, 48(5):646-790.
55. Regional Agency for the Environmental Protection (ARPA Lazio). Relazione qualità dell'aria urbana nel Comune di Roma. Anno 2004-2008. Available at: 〈〉 (accessed 18 march 2010). http://www.arpalazio.net/main/.
56. Robalo-Cordeiro A.J. Bronchitis and emphysema: importance of environmental factors and prevention. Eur. J. Respir. Dis. 1986, 146:99-107.
57. Saenghirunvattana S., Boontes N., Vongvivat K. Abnormal pulmonary function among traffic policemen in Bangkok. J. Med. Assoc. Thailand 1995, 78(12):686-687.
58. Singh V., Sharma B.B., Yadav R., Meena P. Respiratory morbidity attributed to auto-exhaust pollution in traffic policemen of Jaipur, India. J. Asthma 2009, 46(2):118-121.
59. Sint T., Donohue J.F., Ghio A.J. Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease. Inhal. Toxicol. 2008, 20:25-29.
60. Swensen S.J., Jett J.R., Sloan J.A., Midthun D.E., Hartman T.E., Sykes A.M., Aughenbaugh G.L., Zink F.E., Hillman S.L., Noetzel G.R., Marks R.S., Clayton A.C., Pairolero P.C. Screening for lung cancer with low-dose spiral computed tomography. Am. J. Respir. Crit. Care Med. 2002, 165:508-513.
61. Tamura K., Jinsart W., Yano E., Karita K., Boudoung D. Particulate air pollution and chronic respiratory symptoms among traffic policemen in Bangkok. Arch. Environ. Health 2003, 58(4):201-207.
62. Tiitola M., Kivisaari L., Huuskonen M.S., Mattson K., Koskinen H., Lehtola H., Zitting A., Vehmas T. Computed tomography screening for lung cancer in asbestos-exposed workers. Lung Cancer 2002, 35(1):17-22.
63. Tomao E., Baccolo T.P., Sacchi L., De Sio S., Tomei F. Harm to the liver among employees of the municipal police force. Int. J. Environ. Health R 2002, 12:145-151.
64. Tomao E., Tomei G., Rosati M.V., Caciari T., Danese D., Gamberale D., Vacca D., Palermo P., Anzelmo V., Tomei F. Luteinizing hormone (LH) levels in male workers exposed to urban stressors. Sci. Total Environ. 2009, 407:4591-4595.
65. Tomei F., Ghittori S., Imbriani M., Pavanello S., Carere A., Marcon F., Martini A., Baccolo T.P., Tomao E., Zijno A., Crebelli R. Environmental and biological monitoring of traffic wardens from the city of Rome. Occup. Med. 2001, 51(3):198-203.
66. Tomei F., Rosati M.V., Baccolo T.P., Bernardini A., Ciarrocca M., Caciari T., Tomao E. Response of lympho-monocytes to phytohemagglutinin in urban workers. Environ. Toxicol. Pharmacol. 2004, 17(1):13-18.
67. Tomei F., Rosati M.V., Baccolo T.P., Cherubini E., Ciarrocca M., Caciari T., Tomao E. Ambulatory (24 hour) blood pressure monitoring in police officers. J. Occup. Health 2004, 46:235-243.
68. Tomei F., Rosati M.V., Ciarrocca M., Marchetti M.R., Baccolo T.P., Anzelmo V., Tomao E. Urban pollution and nickel concentration in serum. Int. J. Environ. Health Res. 2004, 14:65-74.
69. Tomei G., Ciarrocca M., Capozzella A., Fiaschetti M., Tomao E., Cangemi C., Rosati M.V., Cerratti D., Anzani M.F., Pimpinella B., Monti C., Tomei F. Hemopoietic system in traffic police exposed to urban stressor. Ind. Health. 2008, 46(3):298-301.
70. Veronesi G., Bellomi M., Veronesi U., Paganelli G., Maisonneuve P., Scanagatta P., Leo F., Pelosi G., Travaini L., Rampinelli C., Trifir G., Sonzogni A., Spaggiari L. Role of positron emission tomography scanning in the management of lung nodules detected at baseline computed tomography screening. Ann. Torac. Surg. 2007, 84:959-966.
71. Vineis P., Hoek G., Krzyzanowski M., Vigna-Taglianti F., Veglia F., Airoldi L., Autrup H., Dunning A., Garte S., Hainaut P., Malaveille C., Matullo G., Overvad K., Raaschou-Nielsen O., Clavel-Chapelon F., Linseisen J., Boeing H., Trichopoulou A., Palli D., Peluso M., Krogh V., Tumino R., Panico S., Bueno-De-Mesquita H.B., Peeters P.H., Lund E.E., Gonzalez C.A., Martinez C., Dorronsoro M., Barricarte A., Cirera L., Quiros J.R., Berglund G., Forsberg B., Day N.E., Key T.J., Saracci R., Kaaks R., Riboli E. Air pollution and risk of lung cancer in a prospective study in Europe. Int. J. Cancer 2006, 119:169-174.
72. Vineis P., Hoek G., Krzyzanowski M., Vigna-Taglianti F., Veglia F., Airoldi L., Overvad K., Raaschou-Nielsen O., Clavel-Chapelon F., Linseisen J., Boeing H., Trichopoulou A., Palli D., Krogh V., Tumino R., Panico S., Bueno-De-Mesquita H.B., Peeters P.H., Lund E.E., Agudo A., Martinez C., Dorronsoro M., Barricarte A., Cirera L., Quiros J.R., Berglund G., Manjer J., Forsberg B., Day N.E., Key T.J., Kaaks R., Saracci R., Riboli E. Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study. Environ. Health 2007, 6:1-7.
73. Violante F., Barbieri A., Curti S., Sanguinetti G., Graziosi F., Mattioli S. Urban atmospheric pollution: personal exposure versus fixed monitoring station measurements. Chemosphere 2006, 64(10):1722-1729.
74. Volpino P., Tomei F., La Valle C., Tomao E., Rosati M.V., Ciarrocca M., De Sio S., Cangemi B., Vigliarolo R., Fedele F. Respiratory and cardiovascular function at rest and during exercise testing in a healthy working population: effects of outdoor traffic air pollution. Occup. Med. 2004, 54:475-482.
75. Wingo P.A., Ries L.A., Giovino G.A., Miller D.S., Rosenberg H.M., Shopland D.R., Thun M.J., Edwards B.K. Annual report to the nation on the status of cancer, 1973-1996, with a special section on lung cancer and tobacco smoking. J. Natl. Cancer Inst. 1999, 91(8):675-690.
76. Wiwanitkit V., Suwansaksri J., Soogarun S. Cancer risk for Thai traffic police exposed to traffic benzene vapour. Asian Pac. J. Cancer Prev. 2005, 6(2):219-220.
77. Wongsurakiat P., Maranetra K.N., Nana A., Naruman C., Aksornint M., Chalermsanyakorn T. Respiratory symptoms and pulmonary function of traffic policemen in Thonburi. J. Med. Assoc. Thailand 1999, 82(5):435-443.
78. Zhu W.C., Chen Q., Chu X.W., Luo C.L., Wu M., Wang Y.X., Chen S.D. Study on serum p53 protein in cops in Guangzhou city. Zhonghua Liu Xing Bing Xue Za Zhi 2003, 24(10):872-874.