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Volumn 62, Issue 6, 2010, Pages 429-435

Aboard transthyretin: From transport to cleavage

Author keywords

Amyloid peptide; Apolipoprotein A I; Metallothionein 2; Retinol; Thyroxine; Transthyretin

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; APOLIPOPROTEIN A1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEGALIN; MEMBRANE RECEPTOR; METALLOTHIONEIN II; NORADRENALIN; PERLECAN; PREALBUMIN; PROTEINASE; PTERIN; RETINOL; RETINOL BINDING PROTEIN; THYROXINE; XANTHOPHYLL;

EID: 77953605034     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.340     Document Type: Review
Times cited : (50)

References (60)
  • 1
    • 0001435965 scopus 로고
    • An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins
    • Kabat, E. A., Moore, D. H., and Landow, H. (1942) An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins. J. Clin. Invest. 21, 571-577.
    • (1942) J. Clin. Invest. , vol.21 , pp. 571-577
    • Kabat, E.A.1    Moore, D.H.2    Landow, H.3
  • 2
    • 0022202960 scopus 로고
    • Demonstration of transthyretin mRNA in the brain and other extrahepatic tissues in the rat
    • Soprano, D. R., Herbert, J., Soprano, K. J., Schon, E. A., and Goodman, D. S. (1985) Demonstration of transthyretin mRNA in the brain and other extrahepatic tissues in the rat. J. Biol. Chem. 260, 11793-11798.
    • (1985) J. Biol. Chem. , vol.260 , pp. 11793-11798
    • Soprano, D.R.1    Herbert, J.2    Soprano, K.J.3    Schon, E.A.4    Goodman, D.S.5
  • 4
    • 0014312168 scopus 로고
    • The contribution of thyroxinebinding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption
    • Woeber, K. A. and Ingbar, S. H. (1968) The contribution of thyroxinebinding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption. J. Clin. Invest. 47, 1710-1721.
    • (1968) J. Clin. Invest. , vol.47 , pp. 1710-1721
    • Woeber, K.A.1    Ingbar, S.H.2
  • 5
    • 0022169949 scopus 로고
    • Retinoids and retinol-binding proteins
    • Goodman, D. (1987) Retinoids and retinol-binding proteins. Harvey Lect. 81, 111-132.
    • (1987) Harvey Lect. , vol.81 , pp. 111-132
    • Goodman, D.1
  • 7
    • 18544370514 scopus 로고    scopus 로고
    • Deciphering cryptic proteases
    • Liz, M. A. and Sousa, M. M. (2005) Deciphering cryptic proteases. Cell. Mol. Life Sci. 62, 989-1002.
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 989-1002
    • Liz, M.A.1    Sousa, M.M.2
  • 8
    • 0035018450 scopus 로고    scopus 로고
    • Transthyretin mutations in hyperthyroxinemia and amyloid diseases
    • Saraiva, M. J. (2001) Transthyretin mutations in hyperthyroxinemia and amyloid diseases. Hum. Mutat. 17, 493-503.
    • (2001) Hum. Mutat. , vol.17 , pp. 493-503
    • Saraiva, M.J.1
  • 9
    • 34848818080 scopus 로고    scopus 로고
    • Transthyretin enhances nerve regeneration
    • Fleming, C. E., Saraiva, M. J., and Sousa, M. M. (2007) Transthyretin enhances nerve regeneration. J. Neurochem. 103, 831-839.
    • (2007) J. Neurochem. , vol.103 , pp. 831-839
    • Fleming, C.E.1    Saraiva, M.J.2    Sousa, M.M.3
  • 11
    • 30744463914 scopus 로고    scopus 로고
    • Transthyretin knockouts are a new mouse model for increased neuropeptide Y
    • Nunes, A. F., Saraiva, M. J., and Sousa, M. M. (2006) Transthyretin knockouts are a new mouse model for increased neuropeptide Y. FASEB J. 20, 166-168.
    • (2006) FASEB J. , vol.20 , pp. 166-168
    • Nunes, A.F.1    Saraiva, M.J.2    Sousa, M.M.3
  • 13
    • 0025361332 scopus 로고
    • Recent achievements in studies on thyroid hormone- binding proteins
    • Bartalena, L. (1990) Recent achievements in studies on thyroid hormone- binding proteins. Endocr. Rev. 11, 47-64.
    • (1990) Endocr. Rev. , vol.11 , pp. 47-64
    • Bartalena, L.1
  • 14
    • 0017824077 scopus 로고
    • Structure of prealbumin: Secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A
    • Blake, C. C., Geisow, M. J., Oatley, S. J., Rerat, B., and Rerat, C. (1978) Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A. J. Mol. Biol. 121, 339-356.
    • (1978) J. Mol. Biol. , vol.121 , pp. 339-356
    • Blake, C.C.1    Geisow, M.J.2    Oatley, S.J.3    Rerat, B.4    Rerat, C.5
  • 15
    • 0016428708 scopus 로고
    • Negative cooperativity in the binding of thyroxine to human serum prealbumin. Preparation of tritium-labeled 8-anilino-1- naphthalenesulfonic acid
    • Ferguson, R. N., Edelhoch, H., Saroff, H. A., Robbins, J., and Cahnmann, H. J. (1975) Negative cooperativity in the binding of thyroxine to human serum prealbumin. Preparation of tritium-labeled 8-anilino-1- naphthalenesulfonic acid. Biochemistry 14, 282-289.
    • (1975) Biochemistry , vol.14 , pp. 282-289
    • Ferguson, R.N.1    Edelhoch, H.2    Saroff, H.A.3    Robbins, J.4    Cahnmann, H.J.5
  • 17
    • 0030993449 scopus 로고    scopus 로고
    • Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretinnull mice
    • Palha, J. A., Hays, M. T., Morreale de Escobar, G., Episkopou, V., Gottesman, M. E., and Saraiva, M. J. (1997) Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretinnull mice. Am. J. Physiol. 272, E485-493.
    • (1997) Am. J. Physiol. , vol.272
    • Palha, J.A.1    Hays, M.T.2    De Escobar, M.G.3    Episkopou, V.4    Gottesman, M.E.5    Saraiva, M.J.6
  • 18
    • 0024430817 scopus 로고
    • The free hormone hypothesis: A physiologically based mathematical model
    • Mendel, C. M. (1989) The free hormone hypothesis: a physiologically based mathematical model. Endocr. Rev. 10, 232-274.
    • (1989) Endocr. Rev. , vol.10 , pp. 232-274
    • Mendel, C.M.1
  • 20
    • 0021174089 scopus 로고
    • Vitamin A and retinoids in health and disease
    • Goodman, D. S. (1984) Vitamin A and retinoids in health and disease. N. Engl. J. Med. 310, 1023-1031.
    • (1984) N. Engl. J. Med. , vol.310 , pp. 1023-1031
    • Goodman, D.S.1
  • 21
    • 0021258853 scopus 로고
    • Multiple functions of vitamin A
    • Wolf, G. (1984) Multiple functions of vitamin A. Physiol. Rev. 64, 873-937.
    • (1984) Physiol. Rev. , vol.64 , pp. 873-937
    • Wolf, G.1
  • 22
    • 0026468669 scopus 로고
    • Interactions of retinol with binding proteins: studies with retinol-binding protein and with transthyretin
    • Noy, N., Slosberg, E., and Scarlata, S. (1992) Interactions of retinol with binding proteins: studies with retinol-binding protein and with transthyretin. Biochemistry 31, 11118-11124.
    • (1992) Biochemistry , vol.31 , pp. 11118-11124
    • Noy, N.1    Slosberg, E.2    Scarlata, S.3
  • 23
    • 0033515058 scopus 로고    scopus 로고
    • The structure of human retinol- binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP
    • Naylor, H. M. and Newcomer, M. E. (1999) The structure of human retinol- binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. Biochemistry 38, 2647-2653.
    • (1999) Biochemistry , vol.38 , pp. 2647-2653
    • Naylor, H.M.1    Newcomer, M.E.2
  • 24
    • 0029062667 scopus 로고
    • Structure of a complex of two plasma proteins: Transthyretin and retinol-binding protein
    • Monaco, H. L., Rizzi, M., and Coda, A. (1995) Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science 268, 1039-1041.
    • (1995) Science , vol.268 , pp. 1039-1041
    • Monaco, H.L.1    Rizzi, M.2    Coda, A.3
  • 27
    • 0028959254 scopus 로고
    • Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination
    • Wei, S., Episkopou, V., Piantedosi, R., Maeda, S., Shimada, K., Gottesman, M. E., and Blaner, W. S. (1995) Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination. J. Biol. Chem. 270, 866-870.
    • (1995) J. Biol. Chem. , vol.270 , pp. 866-870
    • Wei, S.1    Episkopou, V.2    Piantedosi, R.3    Maeda, S.4    Shimada, K.5    Gottesman, M.E.6    Blaner, W.S.7
  • 28
    • 33846946440 scopus 로고    scopus 로고
    • A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
    • Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., and Sun, H. (2007) A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 315, 820-825.
    • (2007) Science , vol.315 , pp. 820-825
    • Kawaguchi, R.1    Yu, J.2    Honda, J.3    Hu, J.4    Whitelegge, J.5    Ping, P.6    Wiita, P.7    Bok, D.8    Sun, H.9
  • 29
    • 0035958040 scopus 로고    scopus 로고
    • Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)- sensitive receptor
    • Sousa, M. M. and Saraiva, M. J. (2001) Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)- sensitive receptor. J. Biol. Chem. 276, 14420-14425.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14420-14425
    • Sousa, M.M.1    Saraiva, M.J.2
  • 30
    • 0025115983 scopus 로고
    • Transthyretin receptors on human astrocytoma cells
    • Divino, C. M. and Schussler, G. C. (1990) Transthyretin receptors on human astrocytoma cells. J. Clin. Endocrinol. Metab. 71, 1265-1268.
    • (1990) J. Clin. Endocrinol. Metab. , vol.71 , pp. 1265-1268
    • Divino, C.M.1    Schussler, G.C.2
  • 31
    • 0034617493 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis of transthyretin by ependymoma cells
    • Kuchler-Bopp, S., Dietrich, J. B., Zaepfel, M., and Delaunoy, J. P. (2000) Receptor-mediated endocytosis of transthyretin by ependymoma cells. Brain Res. 870, 185-194.
    • (2000) Brain Res. , vol.870 , pp. 185-194
    • Kuchler-Bopp, S.1    Dietrich, J.B.2    Zaepfel, M.3    Delaunoy, J.P.4
  • 32
    • 0028801506 scopus 로고
    • Transport of serum transthyretin into chicken oocytes. A receptor-mediated mechanism
    • Vieira, A. V., Sanders, E. J., and Schneider, W. J. (1995) Transport of serum transthyretin into chicken oocytes. A receptor-mediated mechanism. J. Biol. Chem. 270, 2952-2956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 2952-2956
    • Vieira, A.V.1    Sanders, E.J.2    Schneider, W.J.3
  • 35
    • 63849199799 scopus 로고    scopus 로고
    • Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity
    • Fleming, C. E., Mar, F. M., Franquinho, F., Saraiva, M. J., and Sousa, M. M. (2009) Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity. J. Neurosci. 29, 3220-3232.
    • (2009) J. Neurosci. , vol.29 , pp. 3220-3232
    • Fleming, C.E.1    Mar, F.M.2    Franquinho, F.3    Saraiva, M.J.4    Sousa, M.M.5
  • 36
    • 0342646984 scopus 로고    scopus 로고
    • Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation
    • Sousa, M. M., Yan, S. D., Stern, D., and Saraiva, M. J. (2000) Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation. Lab. Invest. 80, 1101-1110.
    • (2000) Lab. Invest. , vol.80 , pp. 1101-1110
    • Sousa, M.M.1    Yan, S.D.2    Stern, D.3    Saraiva, M.J.4
  • 37
    • 0026353642 scopus 로고
    • Not norepinephrine but its oxidation products bind specifically to plasma proteins
    • Boomsma, F., Man in 't Veld, A. J., and Schalekamp, M. A. (1991) Not norepinephrine but its oxidation products bind specifically to plasma proteins. J. Pharmacol. Exp. Ther. 259, 551-557.
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 551-557
    • Boomsma, F.1    Man in 't Veld A., J.2    Schalekamp, M.A.3
  • 38
    • 0029031171 scopus 로고
    • Lutein associated with a transthyretin indicates carotenoid derivation and novel multiplicity of transthyretin ligands
    • Pettersson, T., Ernstrom, U., Griffiths, W., Sjovall, J., Bergman, T., and Jornvall, H. (1995) Lutein associated with a transthyretin indicates carotenoid derivation and novel multiplicity of transthyretin ligands. FEBS Lett. 365, 23-26.
    • (1995) FEBS Lett. , vol.365 , pp. 23-26
    • Pettersson, T.1    Ernstrom, U.2    Griffiths, W.3    Sjovall, J.4    Bergman, T.5    Jornvall, H.6
  • 39
    • 0028899920 scopus 로고
    • A yellow component associated with human transthyretin has properties like a pterin derivative,7,8-dihydropterin-6-Carboxaldehyde
    • Ernstrom, U., Pettersson, T., and Jornvall, H. (1995) A yellow component associated with human transthyretin has properties like a pterin derivative, 7,8-dihydropterin-6-carboxaldehyde. FEBS Lett. 360, 177-182.
    • (1995) FEBS Lett. , vol.360 , pp. 177-182
    • Ernstrom, U.1    Pettersson, T.2    Jornvall, H.3
  • 40
    • 33644874465 scopus 로고    scopus 로고
    • Use of a 13C tracer to investigate lutein as a ligand for plasma transthyretin in humans
    • Chen, L., Collins, X. H., Tabatabai, L. B., and White, W. S. (2005) Use of a 13C tracer to investigate lutein as a ligand for plasma transthyretin in humans. Lipids 40, 1013-1022.
    • (2005) Lipids , vol.40 , pp. 1013-1022
    • Chen, L.1    Collins, X.H.2    Tabatabai, L.B.3    White, W.S.4
  • 41
    • 0028801805 scopus 로고
    • Purification and characterization of amyloid-related transthyretin associated with familial amyloidotic cardiomyopathy
    • Hermansen, L. F., Bergman, T., Jornvall, H., Husby, G., Ranlov, I., and Sletten, K. (1995) Purification and characterization of amyloid-related transthyretin associated with familial amyloidotic cardiomyopathy. Eur. J. Biochem. 227, 772-779.
    • (1995) Eur. J. Biochem. , vol.227 , pp. 772-779
    • Hermansen, L.F.1    Bergman, T.2    Jornvall, H.3    Husby, G.4    Ranlov, I.5    Sletten, K.6
  • 42
    • 0030867472 scopus 로고    scopus 로고
    • Binding of perlecan to transthyretin in vitro
    • Smeland, S., Kolset, S. O., Lyon, M., Norum, K. R., and Blomhoff, R. (1997) Binding of perlecan to transthyretin in vitro. Biochem. J. 326(Part 3), 829-836.
    • (1997) Biochem. J. , vol.326 , Issue.PART 3 , pp. 829-836
    • Smeland, S.1    Kolset, S.O.2    Lyon, M.3    Norum, K.R.4    Blomhoff, R.5
  • 43
    • 0026740935 scopus 로고
    • A critical analysis of postulated pathogenetic mechanisms in amyloidogenesis
    • Kisilevsky, R., Lyon, A. W., and Young, I. D. (1992) A critical analysis of postulated pathogenetic mechanisms in amyloidogenesis. Crit. Rev. Clin. Lab. Sci. 29, 59-82.
    • (1992) Crit. Rev. Clin. Lab. Sci. , vol.29 , pp. 59-82
    • Kisilevsky, R.1    Lyon, A.W.2    Young, I.D.3
  • 44
    • 4544363879 scopus 로고    scopus 로고
    • Transthyretin interacts with the lysosome-associated membrane protein (LAMP-1) in circulation
    • Chang, M. H., Hua, C. T., Isaac, E. L., Litjens, T., Hodge, G., Karageorgos, L. E., and Meikle, P. J. (2004) Transthyretin interacts with the lysosome-associated membrane protein (LAMP-1) in circulation. Biochem. J. 382, 481-489.
    • (2004) Biochem. J. , vol.382 , pp. 481-489
    • Chang, M.H.1    Hua, C.T.2    Isaac, E.L.3    Litjens, T.4    Hodge, G.5    Karageorgos, L.E.6    Meikle, P.J.7
  • 45
    • 0035826761 scopus 로고    scopus 로고
    • Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma
    • Purkey, H. E., Dorrell, M. I., and Kelly, J. W. (2001) Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proc. Natl. Acad. Sci. USA 98, 5566-5571.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5566-5571
    • Purkey, H.E.1    Dorrell, M.I.2    Kelly, J.W.3
  • 48
    • 0028181068 scopus 로고
    • Changed affinity of apolipoprotein AII to high density lipoprotein (HDL) in patients with familial amyloidotic polyneuropathy (FAP) type I
    • Tanaka, Y., Ando, Y., Kumamoto, T., Miyazaki, A., Nakamura, M., Nakayama, M., Araki, S., and Ando, M. (1994) Changed affinity of apolipoprotein AII to high density lipoprotein (HDL) in patients with familial amyloidotic polyneuropathy (FAP) type I. Biochim. Biophys. Acta 1225, 311-316.
    • (1994) Biochim. Biophys. Acta , vol.1225 , pp. 311-316
    • Tanaka, Y.1    Ando, Y.2    Kumamoto, T.3    Miyazaki, A.4    Nakamura, M.5    Nakayama, M.6    Araki, S.7    Ando, M.8
  • 49
    • 0033976870 scopus 로고    scopus 로고
    • Transthyretin in high density lipoproteins: Association with apolipoprotein A-I
    • Sousa, M. M., Berglund, L., and Saraiva, M. J. (2000) Transthyretin in high density lipoproteins: association with apolipoprotein A-I. J. Lipid Res. 41, 58-65.
    • (2000) J. Lipid Res. , vol.41 , pp. 58-65
    • Sousa, M.M.1    Berglund, L.2    Saraiva, M.J.3
  • 50
    • 0033898466 scopus 로고    scopus 로고
    • Apolipoprotein AI and transthyretin as components of amyloid fibrils in a kindred with apoAI Leu178His amyloidosis
    • de Sousa, M. M., Vital, C., Ostler, D., Fernandes, R., Pouget-Abadie, J., Carles, D., and Saraiva, M. J. (2000) Apolipoprotein AI and transthyretin as components of amyloid fibrils in a kindred with apoAI Leu178His amyloidosis. Am. J. Pathol. 156, 1911-1917.
    • (2000) Am. J. Pathol. , vol.156 , pp. 1911-1917
    • De Sousa, M.M.1    Vital, C.2    Ostler, D.3    Fernandes, R.4    Pouget-Abadie, J.5    Carles, D.6    Saraiva, M.J.7
  • 52
    • 35848967214 scopus 로고    scopus 로고
    • ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity
    • Liz, M. A., Gomes, C. M., Saraiva, M. J., and Sousa, M. M. (2007) ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity. J. Lipid Res. 48, 2385-2395.
    • (2007) J. Lipid Res. , vol.48 , pp. 2385-2395
    • Liz, M.A.1    Gomes, C.M.2    Saraiva, M.J.3    Sousa, M.M.4
  • 53
    • 0029063033 scopus 로고
    • Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid
    • Golabek, A., Marques, M. A., Lalowski, M., and Wisniewski, T. (1995) Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid. Neurosci. Lett. 191, 79-82.
    • (1995) Neurosci. Lett. , vol.191 , pp. 79-82
    • Golabek, A.1    Marques, M.A.2    Lalowski, M.3    Wisniewski, T.4
  • 54
    • 40149086952 scopus 로고    scopus 로고
    • Transthyretin binding to A-beta peptide-impact on A-Beta fibrillogenesis and toxicity
    • Costa, R., Goncalves, A., Saraiva, M. J., and Cardoso, I. (2008) Transthyretin binding to A-beta peptide-impact on A-Beta fibrillogenesis and toxicity. FEBS Lett. 582, 936-942.
    • (2008) FEBS Lett. , vol.582 , pp. 936-942
    • Costa, R.1    Goncalves, A.2    Saraiva, M.J.3    Cardoso, I.4
  • 55
    • 51449096179 scopus 로고    scopus 로고
    • Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the Kunitz protease inhibitor
    • Costa, R., Ferreira-da-Silva, F., Saraiva, M. J., and Cardoso, I. (2008) Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor. PLoS One 3, e2899.
    • (2008) PLoS One , vol.3
    • Costa, R.1    Ferreira-da-Silva, F.2    Saraiva, M.J.3    Cardoso, I.4
  • 57
    • 18844466386 scopus 로고    scopus 로고
    • Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: Relation with the senile plaques and cytoskeleton biochemistry
    • Merched, A., Serot, J. M., Visvikis, S., Aguillon, D., Faure, G., and Siest, G. (1998) Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: relation with the senile plaques and cytoskeleton biochemistry. FEBS Lett. 425, 225-228.
    • (1998) FEBS Lett. , vol.425 , pp. 225-228
    • Merched, A.1    Serot, J.M.2    Visvikis, S.3    Aguillon, D.4    Faure, G.5    Siest, G.6
  • 58
    • 0036759157 scopus 로고    scopus 로고
    • Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways
    • Stein, T. D. and Johnson, J. A. (2002) Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways. J. Neurosci. 22, 7380-7388.
    • (2002) J. Neurosci. , vol.22 , pp. 7380-7388
    • Stein, T.D.1    Johnson, J.A.2
  • 59
    • 34347364708 scopus 로고    scopus 로고
    • Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin)
    • Choi, S. H., Leight, S. N., Lee, V. M., Li, T., Wong, P. C., Johnson, J. A., Saraiva, M. J., and Sisodia, S. S. (2007) Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J. Neurosci. 27, 7006-7010.
    • (2007) J. Neurosci. , vol.27 , pp. 7006-7010
    • Choi, S.H.1    Leight, S.N.2    Lee, V.M.3    Li, T.4    Wong, P.C.5    Johnson, J.A.6    Saraiva, M.J.7    Sisodia, S.S.8
  • 60
    • 33845953463 scopus 로고    scopus 로고
    • Kinetics of inhibition of beta-amyloid aggregation by transthyretin
    • Liu, L. and Murphy, R. M. (2006) Kinetics of inhibition of beta-amyloid aggregation by transthyretin. Biochemistry 45, 15702-15709.
    • (2006) Biochemistry , vol.45 , pp. 15702-15709
    • Liu, L.1    Murphy, R.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.