RBC-Y/MCV as a discriminant function for differentiating carriers of thalassaemia and HbE from iron deficiency

International Journal of Laboratory Hematology

Volumn 32, Issue 2, 2010, Pages 215-221

  Nadarajan, V S ^a   Sthaneshwar , P ^a   Jayaranee, S ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Anaemia of chronic disease; Haemoglobinopathy; Iron deficiency; RBC Y; Sysmex; Thalassaemia

Indexed keywords

HEMOGLOBIN E; HEMOGLOBIN H;

ALPHA THALASSEMIA; ANEMIA; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DISEASE CARRIER; ERYTHROCYTE; GENETIC TRAIT; HEMATOLOGICAL PARAMETERS; HUMAN; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; POPULATION; PREVALENCE; PRIORITY JOURNAL; RBC Y; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; THALASSEMIA;

ANEMIA, IRON-DEFICIENCY; FLOW CYTOMETRY; GENETIC VARIATION; HEMOGLOBIN E; HETEROZYGOTE; HUMANS; REFERENCE STANDARDS; ROC CURVE; THALASSEMIA;

EID: 77953601297     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2009.01174.x     Document Type: Article

References (18)

1. Agorasti A, Trivellas T, Papadopoulos V & Konstantinidou D (2007) Innovative parameters RET-Y, sTfR, and sTfR-F index in patients with microcytic, hypochromic anemia - their special value for hemoglobinopathies. Laboratory Hematology 13, 63-68.
2. Anonymous (1998) The laboratory diagnosis of haemoglobinopathies. British Journal Haematology 101, 783-792.
3. Beyan C, Kaptan K & Ifran A (2007) Predictive value of discrimination indices in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. European Journal of Haematology 78, 524-526.
4. Buttarello M, Temporin V, Ceravolo R, Farina G & Bulian P (2004) The new reticulocyte parameter (RET-Y) of the Sysmex XE 2100: its use in the diagnosis and monitoring of posttreatment sideropenic anemia. American Journal of Clinical Pathology 121, 489-495.
5. Chern JP, Lin KH, Su YN, Lu MY, Jou ST, Lin DT, Wang SC & Lin KS (2006) Impact of a national beta-thalassemia carrier screening program on the birth rate of thalassemia major. Pediatric Blood Cancer 46, 72-76.
6. Franck S, Linssen J, Messinger M & Thomas L (2004) Potential utility of Ret-Y in the diagnosis of iron-restricted erythropoiesis. Clinical Chemistry 50, 1240-1242.
7. George E & Sivagengei K (1982) Haemoglobin E trait: microcytosis and erythrocytosis. Medical Journal of Malaysia 37, 102-103.
8. Ho WL, Lin KH, Wang JD, Hwang JS, Chung CW, Lin DT, Jou ST, Lu MY & Chern JP (2006) Financial burden of national health insurance for treating patients with transfusion-dependent thalassemia in Taiwan. Bone Marrow Transplantation 37, 569-574.
9. Jindadamrongwech S, Wisedpanichkij R, Bunyaratvej A & Hathirat P (1997) Red cell parameters in alpha-thalassemia with and without beta-thalassemia trait or hemoglobin E trait. Southeast Asian Journal of Tropical Medicine and Public Health 28(Suppl 3), 97-99.
10. Khorasani G, Kosaryan M, Vahidshahi K, Shakeri S & Nasehi MM (2008) Results of the national program for prevention of beta-thalassemia major in the Iranian Province of Mazandaran. Hemoglobin 32, 263-271.
11. Lin CK, Lin JS, Chen SY, Jiang ML & Chiu CF (1992) Comparison of hemoglobin and red blood cell distribution width in the differential diagnosis of microcytic anemia. Archives of Pathology and Laboratory Medicine 116, 1030-1032.
12. Noronha JF & Grotto HZ (2005) Measurement of reticulocyte and red blood cell indices in patients with iron deficiency anemia and beta-thalassemia minor. Clinical Chemistry and Laboratory Medicine 43, 195-197.
13. Ntaios G, Chatzinikolaou A, Saouli Z, Girtovitis F, Tsapanidou M, Kaiafa G, Kontoninas Z, Nikolaidou A, Savopoulos C, Pidonia I & Alexiou-Daniel S (2007) Discrimination indices as screening tests for beta-thalassemic trait. Annals of Hematology 86, 487-491.
14. Sirdah M, Tarazi I, Al Najjar E & Al Haddad R (2008) Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the beta-thalassaemia minor from iron deficiency in Palestinian population. International Journal of Laboratory Hematology 30, 324-330.
15. Thomas C & Thomas L (2002) Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clinical Chemistry 48, 1066-1076
16. Thomas L, Franck S, Messinger M, Linssen J, Thome M & Thomas C (2005) Reticulocyte hemoglobin measurement - comparison of two methods in the diagnosis of iron-restricted erythropoiesis. Clinical Chemistry and Laboratory Medicine 43, 1193-1202.
17. Vichinsky EP (2005) Changing patterns of thalassemia worldwide. Annals of the New York Academy of Sciences 1054, 18-24.
18. Weatherall DJ (2005) Keynote address: the challenge of thalassemia for the developing countries. Annals of the New York Academy of Sciences 1054, 11-17.