Histological and histomorphometrical analysis of a silica matrix embedded nanocrystalline hydroxyapatite bone substitute using the subcutaneous implantation model in Wistar rats

Biomedical Materials

Volumn 5, Issue 3, 2010, Pages

  Ghanaati, Shahram ^a,b   Orth, Carina ^a   Barbeck, Mike ^a   Willershausen, Ines ^a   Thimm, Benjamin W ^c   Booms, Patrick ^d   Stübinger, Stefan ^b   Landes, Constantin ^b   Sader, Robert Anton ^b   Kirkpatrick, Charles James ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c ETH ZURICH   (Switzerland)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APATITE; BIODEGRADATION; BIOLOGICAL MATERIALS; BONE; DEGRADATION; HYDROXYAPATITE; RATS; SILICA;

BONE REGENERATION; BONE SUBSTITUTES; HISTOMORPHOMETRICAL ANALYSIS; IMPLANTATION MODELS; IN-VIVO; INFLAMMATORY RESPONSE; MULTINUCLEATED GIANT CELLS; NANOCRYSTALLINES; PEAK VALUES; SILICA MATRIX; TIME PERIODS; TIME POINTS; TISSUE REACTIONS; VASCULARIZATION; WISTAR RAT;

BIOMATERIALS;

HYDROXYAPATITE; NANOCRYSTAL; BONE PROSTHESIS; DRUG COMBINATION; NANOPARTICLE; SILICON DIOXIDE; SYNTHETIC BONE GRAFT;

ANIMAL TISSUE; ARTICLE; BIODEGRADATION; BONE PROSTHESIS; CONTROLLED STUDY; GIANT CELL; HISTOLOGY; IN VIVO STUDY; LYMPHOCYTE; MACROPHAGE; MORPHOMETRICS; NONHUMAN; RAT; TISSUE REACTION; VASCULARIZATION; ADMINISTRATION AND DOSAGE; ANIMAL; BIODEGRADABLE IMPLANT; CHEMISTRY; DRUG COMBINATION; DRUG EFFECTS; FEMALE; MATERIALS TESTING; PATHOLOGY; SUBCUTANEOUS TISSUE; WISTAR RAT;

RATTUS NORVEGICUS;

ABSORBABLE IMPLANTS; ANIMALS; BONE SUBSTITUTES; DRUG COMBINATIONS; DURAPATITE; FEMALE; MATERIALS TESTING; NANOPARTICLES; RATS; RATS, WISTAR; SILICON DIOXIDE; SUBCUTANEOUS TISSUE;

EID: 77953580580     PISSN: 17486041     EISSN: 1748605X     Source Type: Journal    
DOI: 10.1088/1748-6041/5/3/035005     Document Type: Article

References (51)

1. Damien C J and Parsons J R 1991 Bone graft and bone graft substitutes: a review of current technology and applications J. Appl. Biomater. 2 187-208
2. Lane J M, Tomin E and Bostrom M P 1999 Biosynthetic bone grafting Clin. Orthop. 367 S107-17
3. Kessler P, Thorwarth M, Bloch-Birkholz A, Nkenke E and Neukam F W 2005 Harvesting of bone from the iliac crest-comparison of the anterior and posterior sites Br. J. Oral Maxillofac. Surg. 43 51-6
4. Mazok J B, Schow S R and Triplett R G 2003 Posterior iliac crest bone harvest: review of technique, complications, and postoperative pain control J. Oral Maxillofac. Surg. 61 1497-503
5. Nkenke E, Weisbach V, Winckler E, Kessler P, Schultze-Mosgau S, Wiltfang J and Neukam F W 2004 Morbidity of harvesting of bone grafts from the iliac crest for prosthetic augmentation procedures: a prospective study Int. J. Oral Maxillofac. Surg. 33 157-63
6. Urist M R, Silverman B F, Buring K, Dubuc F L and Rosenberg J M 1967 The bone induction principle Clin. Orthop. 53 243-83
7. Brantigan J W, Cunningham B W, Warden K, McAfee P C and Steffee A D 1993 Compression strength of donor bone for posterior lumbar interbody fusion Spine 18 1213-21
8. Lane J M and Sandhu H S 1987 Current approaches to experimental bone grafting Orthop. Clin. North. Am. 18 213-25
9. Oikarinen J and Korhonen L K 1979 The bone inductive capacity of various bone transplanting materials used for treatment of experimental bone defects Clin. Orthop. 140 208-15
10. Prolo D J and Rodrigo J J 1985 Contemporary bone graft physiology and surgery Clin. Orthop. 200 322-42
11. Oklund S A, Prolo D J, Gutierrez R V and King S E 1986 Quantitative comparisons of healing in cranial fresh autografts, frozen autografts and processed autografts, and allografts in canine skull defects Clin. Orthop. 205 269-91
12. Anderson M, Dhert W and de Bruijn J 1999 Critical size defect in the goat's os ilium. A model to evaluate bone grafts and substitutes Clin. Orthop. 364 231-9
13. Pareek A, Torrelles X, Rius J, Magdans U and Gies H 2007 Role of water in the surface relaxation of the fluorapitite (1 0 0) surface by grazing incidence x-ray diffraction Phys. Rev. B75 035418
14. El-Ghannam A 2005 Bone reconstruction: from bioceramics to tissue engineering Expert Rev. Med. Devices Rev. 2 87-101
15. Barrère F, van Blitterswijk C A and de Groot K 2006 Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics Int. J. Nanomedicine Rev. 1 317-32
16. Jugdaohsingh R 2007 Silicon and bone health J. Nutr. Health Aging Rev. 11 99-100
17. Gerike W, Bienengraeber V, Henkel K-O, Bayerlein T, Proff P, Gedrange T and Gerber T 2006 The manufacture of synthetic non-sintered and degradable bone grafting substitutes Folia Morphol. 65 54-5
18. Gerber T, Holzhueter G, Knoblich B, Doerfling P, Bienengraeber V and Henkel K O 2000 Development of bioactive sol-gel material template for in vitro and in vivo synthesis of bone material J. Sol-Gel Sci. Technol. 19 441-5
19. Gerber T, Traykova T, Henkel K O and Bienengraeber V 2003 Development and in vivo test of sol-gel derived bone grafting materials J. Sol-Gel Sci. Technol. 26 1173-8
20. Bienengraeber V, Gerber T, Henkel K O, Bayerlein T, Proff P and Gedrange T 2006 The clinical application of a new synthetic bone grafting material in oral and maxillofacial surgery Folia Morphol. 65 84-8
21. Gerber T, Holzhueter G, Goetz W, Bienengraeber V, Henkel K O and Rumpel E 2006 Nanostructuring of biomaterials - a pathway to bone grafting substitute Eur. J. Trauma 32 132-40
22. Henkel K O, Gerber T, Lenz S, Gundlach K K H and Bienengraeber V 2006 Macroscopical, histological, and morphometric studies of porous bone-replacement materials in minipigs 8 months after implantation Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 102 606-13
23. Kirchhoff M, Bienengräber V, Lenz S, Gerer T and Henkel K O 2006 A new synthetic bone replacement material with osteoinductive properties-in vivo investigations BIOmaterialien 7 (S1) 80
24. Gerber T, Holzhüter G, Götz W, Bienengräber V and Hinkel E R 2006 Nanostructuring of biomaterials - a pathway to bone grafting substitute Eur. J. Trauma 32 132-40
25. Canullo L and Dellavia C 2009 Sinus lift using a nanocrystalline hydroxyapatite silica gel in severely resorbed maxillae: histological preliminary study Clin. Implant. Dent. Relat. Res. 11 ((Suppl. 1)) e7-13
26. Stübinger S, Ghanaati S, Orth C, Hilbig U, Saldamli B, Biesterfeld S, Kirkpatrick C J and Sader R A 2009 Maxillary sinus grafting with a nano-structured biomaterial: preliminary clinical and histological results Eur. Surg. Res. 42 143-9
27. Abshagen K, Schrodi I, Gerber T and Vollmar B 2009 In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute NanoBone J. Biomed. Mater. Res. A 91 557-66
28. Xu W, Holzhüter G, Sorg H, Wolter D, Lenz S, Gerber T and Vollmar B 2009 Early matrix change of a nanostructured bone grafting substitute in the rat J. Biomed. Mater. Res. B. Appl. Biomater. 91 692-9
29. Fuchs S, Ghanaati S, Orth C, Barbeck M, Kolbe M, Hofmann A, Eblenkamp M, Gomes M, Reis R L and Kirkpatrick C J 2009 Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds Biomaterials 30 526-34
30. Ghanaati S M, Thimm B W, Unger R E, Orth C, Kohler T, Barbeck M, Müller R and Kirkpatrick C J 2010 Collagen-embedded hydroxylapatite-beta- tricalcium phosphate-silicon dioxide bone substitute granules assist rapid vascularization and promote cell growth Biomed. Mater. at press
31. Ghanaati S, Orth C, Deisinger U, Detsch R, Booms P, Unger R, Ziegler G and Kirkpatrick C 2008 The composition of bone substitute materials influences their bioactivity in vivo Biomaterialien 9 90
32. Movat H Z 1955 Demonstration of all connective tissue elements in a single section; pentachrome stains AMA Arch. Pathol. 60 289-95
33. Anderson J M, Rodriguez A and Chang D T 2008 Foreign body reaction to biomaterials Semin. Immunol. 20 86-100
34. Tang L, Jennings T A and Eaton J W 1998 Mast cells mediate acute inflammatory responses to implanted biomaterials Proc. Natl Acad. Sci. USA 95 8841-6
35. Esche C, Stellato C and Beck L A 2005 Chemokines: key players in innate and adaptive immunity I. Invest. Dermatol. 125 615-28
36. Campbell D J, Kim C H and Butcher E C 2003 Chemokines in the systemic organization of immunity Immunol. Rev. 195 58-71
37. Gerard C and Rollins B J 2001 Chemokines and disease Nat. Immunol. Rev. 2 108-15
38. Rhodes N P, Hunt J A and Williams D F 1997 Macrophage subpopulation differentiation by stimulation with biomaterials J. Biomed. Mater. Res. 37 481-8
39. Charo I F and Ransohoff R M 2006 The many roles of chemokines and chemokine receptors in inflammation N. Engl. J. Med. 354 610-21
40. Athanasou N A and Quinn J 1990 Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function J. Clin. Pathol. 43 997-1003
41. Dadsetan M, Jones J A, Hiltner A and Anderson J M 2004 Surface chemistry mediates adhesive structure, cytoskeletal organization, and fusion of macrophages J. Biomed. Mater. Res. A 71 439-48
42. McNally A K and Anderson J M 2005 Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum Exp. Mol. Pathol. 79 126-35
43. Hernandez-Pando R, Bornstein Q L, Aguilar Leon D, Orozco E H, Madrigal V K and Martinez Cordero E 2000 Inflammatory cytokine production by immunological and foreign body multinucleated giant cells Immunology 100 352-8
44. Henson P M 1971 The immunologic release of constituents from neutrophil leukocytes: II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces J. Immunol. 107 1547-57
45. Henson P M 1971 The immunologic release of constituents from neutrophil leukocytes: I. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces J. Immunol. 107 1535-46
46. Kadoya Y, al-Saffar N, Kobayashi A and Revell P A 1994 The expression of osteoclast markers on foreign body giant cells Bone Miner 27 (2) 85-96
47. Ibbotson K J, Roodman G D, McManus L M and Mundy G R 1984 Identification and characterization of osteoclast-like cells and their progenitors in cultures of feline marrow mononuclear cells J. Cell Biol. 99 471-80
48. Hing K A, Best S M, Tanner E, Bonfield W and Revell P A 1997 Biomechanical assessment of bone ingrowth in porous hydroxylapatite J. Mat. Sci. Mat. Med. 9 731-6
49. 2 matrix, poster presentation 21st European Conf. on Biomaterials (Brighton, UK)
50. Ghanaati S, Orth C and Kirkpatrick C J 2008 The morphology of β-TCP- based biomaterials influences their bioactivity in vivo Tissue Eng. A 14 917-8
51. Ghanaati S, Deisinger U, Detsch R, Orth C, Uhl F, Hamisch S, Unger R, Ziegler G and Kirkpatrick J 2008 In vitro and in vivo biocompatibility of HA-scaffolds sintered at different temperatures BIOmaterialien 9 169