Ultrasound stimulation induces PGE2 synthesis promoting cementoblastic differentiation through EP2/EP4 receptor pathway

Ultrasound in Medicine and Biology

Volumn 36, Issue 6, 2010, Pages 907-915

  Rego, Emanuel Braga ^a   Inubushi, Toshihiro ^a   Kawazoe, Aki ^a   Tanimoto, Kotaro ^a   Miyauchi, Mutsumi ^a   Tanaka, Eiji ^b   Takata, Takashi ^a   Tanne, Kazuo ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cementoblasts; EP receptors; Mineralization; Prostaglandin E2; Ultrasound

Indexed keywords

CELL LINES; CEMENTOBLASTS; COX-2 INHIBITORS; CYCLOOXYGENASE 2; DIFFERENTIATION MARKERS; LOW INTENSITY ULTRASOUND; MINERAL DEPOSITIONS; MRNA EXPRESSION; POSITIVE EFFECTS; PROSTAGLANDINE; THERAPEUTIC TOOLS; ULTRASOUND STIMULATION; ULTRASOUND TREATMENTS; UP-REGULATION;

CELL CULTURE; GENE EXPRESSION; METABOLISM; MINERALOGY; MINERALS; SILICATE MINERALS; ULTRASONIC TRANSMISSION;

ULTRASONICS;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; OSTEOPONTIN; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR 1; PROSTAGLANDIN RECEPTOR 2; PROSTAGLANDIN RECEPTOR 3; PROSTAGLANDIN RECEPTOR 4; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4; PTGER2 PROTEIN, MOUSE; PTGER4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CEMENTOBLAST; CEMENTUM; CONTROLLED STUDY; GENE EXPRESSION; MINERALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; TISSUE DIFFERENTIATION; TISSUE REGENERATION; ULTRASOUND THERAPY; UPREGULATION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; ECHOGRAPHY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; ULTRASOUND;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DENTAL CEMENTUM; DINOPROSTONE; MICE; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION; ULTRASONICS; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE;

EID: 77953563757     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2010.03.008     Document Type: Article

References (47)

1. Bosshardt D.D., Degen T., Lsng N.P. Sequence of protein expression of bone sialoprotein and osteopontin at the developing interface between repair cementum and dentin in human deciduous teeth. Cell Tissue Res 2005, 320:399-407.
2. Bosshardt D.D. Are cementoblasts a subpopulation of osteoblasts or a unique phenotype?. J Dent Res 2005, 84:390-406.
3. Breyer R.M., Bagdassarian C.K., Myers S.A., Breyer M.D. Prostanoid receptors: Subtypes and signaling. Ann Rev Pharmacol Toxicol 2001, 41:661-690.
4. Buckley M.J., Banes A.J., Levin L.G., Sumpio B.E., Sato M., Jordan R., Gilbert J., Link G.W., Tran Son Tay R. Osteoblasts increase their rate of division and align in response to cyclic mechanical tension in vitro. Bone Miner 1998, 4:225-236.
5. Camargo P.M., Lagos R., Pirih F.Q., Benitiz A., Nervina J.M., Tetradis S. Prostaglandin E2 and F2alpha enhance differentiation of cementoblastic cells. J Periodontol 2005, 76:303-309.
6. Chen Y.J., Wang C.J., Yang K.D., Chang P.R., Huang H.C., Huang Y.T., Sun Y.C., Wang F.S. Pertussis toxin-sensitive Gαi protein and ERK dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. FEBS Letters 2003, 554:154-158.
7. 2 and a selective EP2 receptor agonist. Prostaglandin Other Lipid Mediat 2008, 86:35-40.
8. Dahl L.K. A simple a sensitive histochemical method for calcium. Proc Soc Exp Biol Med 1952, 80:474-479.
9. Dalla-Bona D.A., Tanaka E., Inubushi T., Oka H., Ohta A., Okada H., Miyauchi M., Takata T., Tanne K. Cementoblast response to low- and high-intensity ultrasound. Arch Oral Biol 2008, 53:318-323.
10. Dalla-Bona D.A., Tanaka E., Oka H., Yamano E., Kawai N., Miyauchi M., Takata T., Tanne K. Effects of ultrasound on cementoblast metabolism in vitro. Ultrasound Med Biol 2006, 32:943-948.
11. Duarte L.R. The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg 1983, 101:153-159.
12. Dyson M. Therapeutic applications of ultrasound. Biological effects of ultrasound 1985, 121-133. Churchill Livingstone, New York. W.L. Nyborg, M.C. Ziskin (Eds.).
13. El-Bialy T., El-Shamy I., Graber T.M. Repair of orthodontically induced root resorption by ultrasound in humans. AJO-DO 2004, 126:186-193.
14. Erdogan O., Esen E., Üstun Y., Kürkçü M., Akova T., Gönlüsen G., Uysal H., Filiz Çevlik F. Effects of low-intensity pulsed ultrasound on healing of mandibular fractures: An experimental study in rabbits. J Oral Maxillofac Surg 2006, 64:180-188.
15. Feng C., Beller E.M., Bagga S., Boyce J.A. Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. Blood 2006, 107:3242-3250.
16. Gebauer D., Correll J. Pulsed low-intensity ultrasound: A new salvage procedure for delayed unions and nonunions after leg lengthening in children. J Pediatr Orthop 2005, 6:750-754.
17. Giancotti F.G., Ruoslahti E. Integrin signaling. Science 1999, 285:28-32.
18. Hatton J.P., Pooran M., Li C.F., Luzzio C., Hughes-Fulford M. A short pulse of mechanical force induces gene expression and growth in MC3T3-E1 osteoblasts via an ERK 1/2 pathway. J Bone Miner Res 2003, 18:58-66.
19. Inubushi T., Tanaka E., Rego E.B., Kitagawa M., Kawazoe A., Ohta A., Okada H., Koolstra J.H., Miyauchi M., Takata T., Tanne K. Effects of ultrasound on the proliferation and differentiation of cementoblast lineage cells. J Periodontol 2008, 79:984-990.
20. Keller J., Klamer A., Bak B., Lind M. Effect of local prostaglandin E2 on fracture callus in rabbits. Acta Orthop Scand 1993, 64:59-63.
21. 2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts. BBRC 1999, 256:284-287.
22. Li M., Thompson D.D., Paralkar V.M. Prostaglandin E2 receptors in bone formation. Inter Orthop 2007, 31:767-772.
23. 2. Mol Pharmacol 2001, 60:36-41.
24. Mada Y., Miyauchi M., Oka H., Kitagawa M., Sakamoto K., Iizuka S., Sato S., Noguchi K., Somerman M.J., Takata T. Effects of endogenous and exogenous prostaglandin E2 on the proliferation and differentiation of a mouse cementoblast cell line (OCCM-30). J Periodontol 2006, 77:2051-2058.
25. Marks S.C., Miller S.C. Local delivery of prostaglandin E1 induces periodontal regeneration in adult dogs. J Periodontal Res 1994, 29:103-108.
26. Matias M.A., Li H., Young W.G., Bartold P.M. Immunohistochemical localization of extracellular matrix proteins in the periodontium during cementogenisis in the rat molar. Arch Oral Biol 2003, 48:709-716.
27. 2 on bone formation in rat calvaria cell cultures. Bone 2009, 44:1177-1185.
28. 2 production appropriately. Life Sci 2005, 77:3168-3182.
29. 2 in chondrocyte differentiation. Osteoarthr Cartil 2003, 11:644-652.
30. Mukai S., Ito H., Nakagawa Y., Akiyama H., Miyamoto M., Nakamura T. Transforming growth factor-β1 mediates the effects of low-intensity pulsed ultrasound in chondrocytes. Ultrasound in Med Biol 2005, 31:1713-1721.
31. 2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation. Bone 2007, 41:543-548.
32. Naruse K., Mikuni-Takagaki Y., Azuma Y., Ito M., Oota T., Kameyama K., Itoman M. Anabolic response of mouse bone-marrow-derived stromal cell clone ST2 cells to low-intensity pulsed ultrasound. Biochem Biophys Res Commun 2000, 268:216-220.
33. Naruse K., Miyauchi A., Itoma M., Mikuni-Takagaki Y. Distinct anabolic response of osteoblasts to low-intensity pulsed ultrasound. J Bone Miner Res 2003, 18:360-369.
34. 2 inhibits mineralization and enhances matrix metalloproteinase-13 in mature cementoblasts mainly via the EP4 pathway. Arch Oral Biol 2008, 53:243-249.
35. 2 activates cementoclastogenesis by cementoblasts via EP4. J Dent Res 2007, 86:974-979.
36. Proffit W.R., Fields H.W., Sarver D.M. Contemporary Orthodontics 2007, Mosby, St. Louis, pp. 350-352. 4th ed.
37. Raisz L.G., Pilbeam C.C., Fall P.M. Prostaglandins: mechanisms of action and regulation of production in bone. Osteoporos Int (Suppl) 1993, 1:136-140.
38. Raisz L.G., Woodiel F.N. Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures. Prostaglandins Other Lipid Mediat 2003, 71:287-292.
39. Ramirez-Yãnes G.O., Seymour G.J., Symons A.L. Local application of prostaglandin E2 reduces trap, calcitonin receptor and metalloproteinase-2 immunoreactivity in the rat periodontium. Arch Oral Biol 2005, 50:1014-1022.
40. Saito M., Fujii K., Tanaka T., Soshi S. Effect of low and high intensity pulsed ultrasound on collagen post-translational modifications in MC3T3-E1 osteoblasts. Calcif Tissue Inter 2004, 75:384-395.
41. Tanaka M., Sakai A., Uchida S., Tanaka S., Masato N., Katayama T., Yamaguchi K., Nakamura T. Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local up regulation of bone turnover in mature rats. Bone 2004, 34:940-948.
42. Tang C.H., Yang R.S., Huang T.H., Lu D.Y., Chuang W.J., Huang T.F., Fu W.M. Ultrasound stimulates Cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, phosphatidylinositol 3-kinase, and Akt pathway is osteoblasts. Molec Pharmacol 2006, 69:2047-2057.
43. Ten Cate A.R. The periodontium: Oral histology, development, structure and function 2003, Mosby, St. Louis, pp. 276-279.
44. Warden S.J., Favaloro J.M., Bennell K.L., McMeeken J.M., Ng K.W., Zajac J.D., Wark J.D. Low-intensity pulsed ultrasound stimulates a bone forming response in UMR-106 cells. Biochem Biophys Res Commun 2001, 286:443-450.
45. Woodiel F.N., Fall P.M., Raisz L.G. Anabolic effects of prostaglandins in cultured fetal calvariae: Structure-activity relations and signal transduction pathway. J Bone Miner Res 1996, 9:1249-1255.
46. Yoshida K., Oida H., Kobayashi T., Maruyama T., Tanaka M., Katayama T. Stimulation of bone formation and prevention of bone loss by prostaglandin receptor E EP4 receptor activation. Proc Natl Acad Sci U S A 2002, 99:4580-4585.
47. Zhao M., Berry J.E., Somerman M.J. Bone morphogenetic protein-2 inhibits differentiation and mineralization of cementoblasts in vitro. J Dent Res 2003, 82:23-27.