High-performance liquid chromatographic method for the quantification of Mitragyna inermis alkaloids in order to perform pharmacokinetic studies

Journal of Separation Science

Volumn 33, Issue 12, 2010, Pages 1863-1869

  Sinou, Veronique ^a   Fiot, Julien ^b   Taudon, Nicolas ^a   Mosnier, Joël ^a   Martelloni, Maryse ^a   Bun, Sok S ^b   Parzy, Daniel ^a   Ollivier, Evelyne ^b  

^a INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

HPLC; Human and pig matrices; Mitragyna inermis; Oxindole alkaloids; Rubiaceae

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; METHANOL; NAPHTHALENE;

ANTIMALARIAL ACTIVITY; BIOLOGICAL MATRIXES; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC SEPARATIONS; CONCENTRATION RANGES; HPLC METHOD; INTERNAL STANDARDS; INTRAVENOUS ADMINISTRATION; MOBILE PHASE; OXINDOLE ALKALOIDS; PHARMACOKINETIC STUDIES; PHOSPHATE BUFFERS; PLASMA SAMPLES; RUBIACEAE;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ALKALOID; ANTIMALARIAL AGENT; MITRAGYNA INERMIS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MITRAGYNA; NONHUMAN; PRIORITY JOURNAL; SWINE; ANIMAL; BLOOD; CHEMISTRY; LIMIT OF DETECTION; PROCEDURES; QUALITY CONTROL; REPRODUCIBILITY; STANDARD; VALIDATION STUDY;

MITRAGYNA INERMIS; RUBIACEAE; SUIDAE;

ALKALOIDS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIMIT OF DETECTION; MITRAGYNA; QUALITY CONTROL; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SWINE;

EID: 77953548955     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201000008     Document Type: Article

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