Mutational analysis of ASPP1 and ASPP2 genes, a p53-related gene, in gastric and cololorectal cancers with microsatellite instability

Gut and Liver

Volumn 4, Issue 2, 2010, Pages 292-293

  Park, Sang Wook ^a   An, Chang Hyeok ^a   Kim, Sung Soo ^a   Yoo, Nam Jin ^a   Lee, Sug Hyung ^a  

^a The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS STIMULATING PROTEIN OF P53 1; APOPTOSIS STIMULATING PROTEIN OF P53 2; CELL PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

CARCINOGENESIS; COLORECTAL CANCER; DNA SEQUENCE; FRAMESHIFT MUTATION; HUMAN; LETTER; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; STOMACH CANCER; TRANSACTIVATION;

EID: 77953547603     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2010.4.2.292     Document Type: Letter

References (6)

1. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000;408:307-310.
2. Samuels-Lev Y, O'Connor DJ, Bergamaschi D, et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001;8:781-794.
3. Kampa KM, Acoba JD, Chen D, et al. Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor- prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A 2009;106:4390-4395.
4. Imai K, Yamamoto H. Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 2008;29:673-680.
5. Lee SH, Shin MS, Park WS, et al. Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer. Oncogene 1999;18:3754-3760.
6. Patel S, George R, Autore F, Fraternali F, Ladbury JE, Nikolova PV. Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax. Nucleic Acids Res 2008;36:5139-5151.