Antioxidant and cytotoxic effect of oxidized lutein in human cervical carcinoma cells (HeLa)

Food and Chemical Toxicology

Volumn 48, Issue 7, 2010, Pages 1811-1816

  Lakshminarayana, Rangaswamy ^a   Sathish, Upparahalli V ^a   Dharmesh, Shylaja M ^a   Baskaran, Vallikannan ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

Antioxidant; Cytotoxicity; HeLa cells; Liposomes; Liquid chromatography mass spectrophotometry; Lutein oxidation products

Indexed keywords

GLUTATHIONE; HYDROCHLORIC ACID; LIPOSOME; MALONALDEHYDE; OXIDIZED LUTEIN; PHOSPHATIDYLCHOLINE; TROMETAMOL; UNCLASSIFIED DRUG; XANTHOPHYLL;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HELA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; ISOMER; MASS SPECTROMETRY; PHOTOOXIDATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; GLUTATHIONE; HELA CELLS; HUMANS; LUTEIN; MALONDIALDEHYDE; MASS SPECTROMETRY; OXIDATION-REDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 77953537676     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2010.04.011     Document Type: Article

References (31)

1. Asai A., Sugawara T., Ono H., Nagao A. Biotransformation of fucoxanthinol into amarouciaxanthin a in mice and hepg2 cells: formation and cytotoxicity of fucoxanthin metabolites. Drug Metab. Dispos. 2004, 32:205-211.
2. Baker D.L., Krol E.S., Jacobsen N., Liebler D.C. Reactions of β-carotene with cigarette smoke oxidants. Identification of carotenoid oxidation products and evaluation of the prooxidant/antioxidant effect. Chem. Res. Toxicol. 1999, 12:535-543.
3. Bausch J., Licchite H., Oesterhelt G., Kister A. Isolation and identification of a major urinary canathaxanthin metabolite in rats. Int. J. Vitam. Nutr. Res. 1999, 69:268-272.
4. Bhosale P., Zhao da Y., Serban B., Bernstein P.S. Identification of 3-methoxy zeaxanthin as a novel age-related carotenoid metabolite in the human macula. Invest. Ophthalmol. Vis. Sci. 2007, 48:1435-1440.
5. Bone R.A., Landrum J.T., Guerra L.H., Ruiz C.A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J. Nutr. 2003, 133:992-998.
6. Britton G. Structure and properties of carotenoids in relation to function. FASEB J. 1995, 9:1551-1558.
7. Chew B.P., Wong M.W., Wong T.S. Effects of lutein from marigold extract on immunity and growth of mammary tumors in mice. Anticancer Res. 1996, 16:3689-3694.
8. Hansen M.B., Nielsen S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 1989, 119:203-210.
9. Hanush M., Stahl W., Schulz W.A., Sies H. Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canathaxanthin. Arch. Bichem. Biophys. 1995, 317:423-428.
10. Hu X., White K.M., Jacobsen N.E., Mangelsedori D.J., Canfield L.M. Inhibition of growth and cholesterol synthesis in breast cancer cells by oxidation products of β-carotene. J. Nutr. Biochem. 1998, 9:567-574.
11. Karas M., Amir H., Fishman D., Danilenko M., Segal S., Nahum A., Koifmann A., Giat Y., Levy J., Sharoni Y. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Nutr. Cancer 2000, 36:101-111.
12. Khachik F., Spangler C.J., Smith J.C. Identification, quantification and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem. 1997, 69:1873-1881.
13. King T.J., Khachik E., Bortkiewicz H., Fukishima L.H., Morioka S., Bertram J.S. Metabolites of dietary carotenoids as potential cancer preventive agents. Pure Appl. Chem. 1997, 69:2135-2140.
14. Kotake N.E., Kushiro M., Zhang H., Sugawara T., Miyashita K., Nagao A. Carotenoids affect proliferation of human prostate cancer cells. J. Nutr. 2001, 131:3303-3306.
15. Krinsky N.I. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu. Rev. Nutr. 2003, 23:171-201.
16. Lai L.S., Chou S.T., Chao W.W. Studies on the antioxidant activities of Hsian-tsao (Mesona procumbens Hemsl) leaf gum. J. Agric. Food Chem. 2001, 49:963-968.
17. Lakshminarayana R., Aruna G., Sangeetha R.K., Bhaskar N., Divakar S., Baskaran V. Possible degradation/biotransformation of lutein in vitro and in vivo: isolation and structural elucidation of lutein metabolites by HPLC and LC-MS (atmospheric pressure chemical ionization). Free Radic. Biol. Med. 2008, 45:982-993.
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein estimation with Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Martin K.R., Eailla M.L., Smith J.C. β-carotene and lutein protect HepG2 human liver cells against oxidant-induced damage. J. Nutr. 1996, 126:2098-2106.
20. Mordi R.C., Walton J.C., Burton G.W., Hughes L., Ingold K.U., Lindsay D.A., Moffatt D.J. Oxidative degradation of β-carotene and β-apo-8'-carotenal. Tetrahedron 1993, 49:911-928.
21. Ohkawa H., Ohishi N., Yagi H. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
22. Satio M., Sakagami H., Fujisawa S. Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Anticancer Res. 2003, 23:4693-4701.
23. Sies H., Stahl W. Carotenoids and intercellular communication via gap junctions. Int. J. Vitam. Res. 1997, 67:364-367.
24. Stahl W., Junghans A., De Boer B., Driomina E.S., Briviba K., Sies H. Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS 1998, 427:305-308.
25. Stivara L.A., Savio M., Quarta S., Scotti C., Cazzalini O., Rossi L., Scovassi I.A., Pizzala R., Melli R., Bianchi L., Vannini V., Prosperi E. The anti-proliferative effect of β-carotene requires p21waf1/cip1 in normal human fibroblasts. Eur. J. Biochem. 2000, 267:2290-2296.
26. Sujaka A., Gabrielskab J., Grudzi skia W., Borcc R., Mazureka P., Gruszeckia W.I. Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects. Arch. Biochem. Biophys. 1999, 371:301-307.
27. Sumantran V.N., Zhang R., Lee D.S., Wicha M.S. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Cancer Epidemiol. Biomarkers Prev. 2000, 9:257-263.
28. Tietze F. Enzymatic method for quantitative determination of nano gram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 1969, 27:502-522.
29. Wolz E., Liechti H., Notter B., Oesterhelt G., Kistler A. Characterization of metabolites of astaxanthin in primary cultures of rat hepatocytes. Drug Metab. Dispos. 1999, 27:456-462.
30. Yeum K.J., Lee-Kim Y.C., Yoon S., Lee K.Y., Park I.S., Lee K.S., Kim B.S., Tang G., Russell R.M., Krinsky N.I. Similar metabolites formed from β-carotene by human gastric mucosal homogenates, lipoxygenase, or linoleic acid hydroperoxide. Arch. Biochem. Biophys. 1995, 321:167-174.
31. Zhang L.X., Coney R.V., Bertram J.S. Carotenoids enhance gap junction communication and inhibit lipid peroxidation in C3H/10T/2 cells: relationship to their cancer chemo preventive action. Carcinogenesis 1991, 12:2109-2114.