Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension

Autonomic and Autacoid Pharmacology

Volumn 30, Issue 3, 2010, Pages 167-172

  González Hernández, M De Lourdes ^a   Godinez Hernandez D ^b   Bobadilla Lugo, R A ^a   Lopez Sanchez P ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^b UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO   (Mexico)

Author keywords

1D receptor; Animal models; AT1 receptor; Hypertension; Preeclampsia; Pregnancy

Indexed keywords

ALPHA 1D ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; BETA ACTIN; HETERODIMER;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIMERIZATION; FEMALE; HUMAN; IMMUNOPRECIPITATION; MATERNAL HYPERTENSION; NONHUMAN; PREECLAMPSIA; RAT; REGULATORY MECHANISM;

ANIMALS; AORTA, ABDOMINAL; BLOOD PRESSURE; BODY WEIGHT; DISEASE MODELS, ANIMAL; FEMALE; FETAL WEIGHT; HYPERTENSION, PREGNANCY-INDUCED; MUSCLE, SMOOTH; PREGNANCY; PROTEIN MULTIMERIZATION; PROTEINURIA; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ADRENERGIC, ALPHA-1;

EID: 77953525974     PISSN: 14748665     EISSN: 14748673     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2009.00446.x     Document Type: Article

References (23)

1. ABDALLA, S., LOTHER, H., ABDEL-TAWAB, A.M. QUITTERER, U. (2001a). The angiotensin II AT2 receptor is an AT1 receptor antagonist. J. Biol. Chem., 276, 39721 39726.
2. ABDALLA, S., LOTHER, H., EL MASSIERY, A. QUITTERER, U. (2001b). Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. Nat. Med., 7, 1003 1009.
3. ABITBOL, M.M. (1982). Simplified technique to produce toxemia in the rat: considerations on cause of toxemia. Clin. Exp. Hypertens., B1, 93 103.
4. ANGUIANO-ROBLEDO, L., REYES-MELCHOR, P.A., BOBADILLA-LUGO, R.A., PEREZ-ALVAREZ, V.M. LOPEZ-SANCHEZ, P. (2007). Renal angiotensin-II receptors expression changes in a model of preeclampsia. Hypertens. Pregnancy, 26, 151 161.
5. BARKI-HARRINGTON, L., LUTTRELL, L.M. ROCKMAN, H.A. (2003). Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. Circulation, 108, 1611 1618.
6. BARNES, P.J. (2006). Receptor heterodimerization: a new level of cross-talk. J. Clin. Invest., 116, 1210 1212.
7. BRACHO-VALDES, I., GODINEZ-HERNANDEZ, D., ARROYO-VICELIS, B., BOBADILLA-LUGO, R.A. LOPEZ-SANCHEZ, P. (2009). Increased alpha-1 adrenoceptor expression in pregnant rats with subrenal aortic coarctation. Hypertens. Pregnancy, 28, 1 15.
8. DEVI, L.A. (2001). Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol. Sci., 22, 532 537.
9. GARCIA-SAINZ, J.A., VAZQUEZ-PRADO, J. DEL CARMEN MEDINA, L. (2000). Alpha 1-adrenoceptors: function and phosphorylation. Eur. J. Pharmacol., 389, 1 12.
10. GRANT, T.L. MCGRATH, J.C. (1988). Interactions between angiotensin II and alpha-adrenoceptor agonists mediating pressor responses in the pithed rat. Br. J. Pharmacol., 95, 1229 1240.
11. HAGUE, C., LEE, S.E., CHEN, Z., PRINSTER, S.C., HALL, R.A. MINNEMAN, K.P. (2006). Heterodimers of alpha1B-and alpha1D-adrenergic receptors form a single functional entity. Mol. Pharmacol., 69, 45 55.
12. HU, Z.W., SHI, X.Y., OKAZAKI, M. HOFFMAN, B.B. (1995). Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol., 268, 1006 1014.
13. HUNYADY, L. CATT, K.J. (2006). Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol. Endocrinol., 20, 953 970.
14. JONES, K.A., BOROWSKY, B., TAMM, J.A., et al. (1998). GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature, 396, 674 679.
15. JORDAN, B.A., TRAPAIDZE, N., GOMES, I., NIVARTHI, R. DEVI, L.A. (2001). Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc. Natl. Acad. Sci. USA, 98, 343 348.
16. KAUPMANN, K., MALITSCHEK, B., SCHULER, V., et al. (1998). GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature, 396, 683 687.
17. LUMBERS, E.R. (1970). Peripheral vascular reactivity to angiotensin and noradrenaline in pregnant and non-pregnant women. Aust. J. Exp. Biol. Med. Sci., 48, 493 500.
18. PALLER, M.S. (1984). Mechanism of decreased pressor responsiveness to ANG II, NE, and vasopressin in pregnant rats. Am. J. Physiol., 247, H100 H108.
19. QUITTERER, U., LOTHER, H. ABDALLA, S. (2004). AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia. Semin. Nephrol., 24, 115 119.
20. SHEN, B., HARRISON-BERNARD, L.M., FULLER, A.J., VANDERPOOL, V., SAIFUDEEN, Z. EL-DAHR, S.S. (2007). The Bradykinin B2 receptor gene is a target of angiotensin II type 1 receptor signaling. J. Am. Soc. Nephrol., 18, 1140 1149.
21. STANASILA, L., PEREZ, J.B., VOGEL, H. COTECCHIA, S. (2003). Oligomerization of the alpha 1a-and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization. J. Biol. Chem., 278, 40239 40251.
22. TOUYZ, R.M. SCHIFFRIN, E.L. (2000). Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev., 52, 639 672.
23. WHITE, M.M., MCCULLOUGH, R.E., DYCKES, R., ROBERTSON, A.D. MOORE, L.G. (1998). Effects of pregnancy and chronic hypoxia on contractile responsiveness to alpha1-adrenergic stimulation. J. Appl. Physiol., 85, 2322 2329.