Solid-tumor radionuclide therapy dosimetry: New paradigms in view of tumor microenvironment and angiogenesis

Medical Physics

Volumn 37, Issue 6, 2010, Pages 2974-2984

  Zhu, Xuping ^a,d   Palmer, Matthew R ^a,b,c   Makrigiorgos, G Mike ^b,c   Kassis, Amin I ^c  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alpha particle emitter; Dosimetry; Electron emitter; Neovasculature targeting; Targeted radionuclide therapy; Tumor targeting; Tumor vascularity

Indexed keywords

ALPHA PARTICLES; BLOOD; BLOOD VESSELS; CYTOLOGY; DEPOSITS; DOSIMETRY; ENDOTHELIAL CELLS; MOLECULES; MONTE CARLO METHODS; RADIATION; RADIOACTIVITY; RADIOISOTOPES;

ELECTRON EMITTERS; NEOVASCULATURE; TARGETED RADIONUCLIDE THERAPIES; TUMOR TARGETING; TUMOR VASCULARITY;

TUMORS;

EID: 77953511570     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3431999     Document Type: Article

References (37)

1. J. M. Brown and A. J. Giaccia, " The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy.," Cancer Res. CNREA8 0008-5472 58, 1408-1416 (1998).
2. R. K. Jain and L. T. Baxter, " Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure.," Cancer Res. CNREA8 0008-5472 48, 7022-7032 (1988).
3. R. K. Jain, " Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.," Cancer Res. CNREA8 0008-5472 50, 814s-819s (1990).
4. R. K. Jain, " Transport of molecules, particles, and cells in solid tumors.," Annu. Rev. Biomed. Eng. ARBEF7 1523-9829 1, 241-263 (1999). 10.1146/annurev.bioeng.1.1.241
5. B. W. Wessels and R. D. Rogus, " Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies.," Med. Phys. MPHYA6 0094-2405 11, 638-645 (1984). 10.1118/1.595559 (Pubitemid 15203652)
6. S. -E. Strand, B. -A. Jönsson, M. Ljungberg, and J. Tennvall, " Radioimmunotherapy dosimetry-A review.," Acta Oncol. ACTOEL 0284-186X 32, 807-817 (1993). 10.3109/02841869309096140
7. D. R. Fisher, " Radiation dosimetry for radioimmunotherapy: An overview of current capabilities and limitations.," Cancer ZZZZZZ 0008-543X 73, 905-911 (1994). 10.1002/1097-0142(19940201)73:3+<905::AID- CNCR2820731324>3.0.CO;2-K
8. J. L. Humm, " Problems and advances in the dosimetry of radionuclide targeted therapy.," Recent Results Cancer Res. ZZZZZZ 0080-0015 141, 37-65 (1996).
9. D. R. Fisher, " Internal dosimetry for systemic radiation therapy.," Semin. Radiat. Oncol. ZZZZZZ 1053-4296 10, 123-132 (2000). 10.1016/S1053-4296(00)80049-1
10. R. W. Howell, D. V. Rao, and K. S. R. Sastry, " Macroscopic dosimetry for radioimmunotherapy: Nonuniform activity distributions in solid tumors.," Med. Phys. MPHYA6 0094-2405 16, 66-74 (1989). 10.1118/1.596404 (Pubitemid 19070520)
11. A. Bao, X. Zhao, W. T. Phillips, F. R. Woolley, R. A. Otto, B. Goins, and J. M. Hevezi, " Theoretical study of the influence of a heterogeneous activity distribution on intratumoral absorbed dose distribution.," Med. Phys. MPHYA6 0094-2405 32, 200-208 (2005). 10.1118/1.1833151 (Pubitemid 40165532)
12. J. Carlsson, E. F. Aronsson, S. -O. Hietala, T. Stigbrand, and J. Tennvall, " Tumor therapy with radionuclides: Assessment of progress and problems.," Radiother. Oncol. RAONDT 0167-8140 66, 107-117 (2003). 10.1016/S0167-8140(02)00374-2 (Pubitemid 36321806)
13. J. Folkman, " Tumor angiogenesis: Therapeutic implications.," N. Engl. J. Med. NEJMAG 0028-4793 285, 1182-1186 (1971).
14. J. Folkman, in Harrison's Principles of Internal Medicine, 15th ed., edited by, E. Braunwald, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, and, J. L. Jameson, (McGraw-Hill, New York, 2001), Vol. 1, pp. 517-530.
15. J. Folkman, " Looking for a good endothelial address.," Cancer Cells ZZZZZZ 1042-2196 1, 113-115 (2002). 10.1016/S1535-6108(02)00038-7 (Pubitemid 41039156)
16. T. Kamijo, T. Yokose, T. Hasebe, H. Yonou, R. Hayashi, S. Ebihara, and A. Ochiai, " Image analysis of microvessel surface area predicts radiosensitivity in early-stage laryngeal carcinoma treated with radiotherapy.," Clin. Cancer Res. ZZZZZZ 1078-0432 7, 2809-2814 (2001).
17. P. Carmeliet and R. K. Jain, " Angiogenesis in cancer and other diseases.," Nature (London) NATUAS 0028-0836 407, 249-257 (2000). 10.1038/35025220
18. L. Hlatky, P. Hahnfeldt, and J. Folkman, " Clinical application of antiangiogenic therapy: Microvessel density, what it does and doesn't tell us.," J. Natl. Cancer Inst. JNCIEQ 0027-8874 94, 883-893 (2002).
19. D. Hanahan and R. A. Weinberg, " The hallmarks of cancer.," Cell CELLB5 0092-8674 100, 57-70 (2000). 10.1016/S0092-8674(00)81683-9
20. A. I. Kassis and S. J. Adelstein, " Radiobiologic principles in radionuclide therapy.," J. Nucl. Med. JNMEAQ 0161-5505 46, 4S-12S (2005).
21. I. Kawrakow and D. W. O. Rogers, " The EGSnrc code system: Monte Carlo simulations of electron and photon transport.," NRCC Report No. PIRS-701 (Ionizing Radiation Standards, National Research Council of Canada, Ottawa, Canada, 2006).
22. ICRU, " Dosimetry of external beta rays for radiation protection.," ICRU Report No. 56 (International Commission on Radiation Units and Measurements, Bethesda, MD, 1997).
23. ICRP, " Radionuclide transformations.," Publication 38 of the International Commission on Radiological Protection (1984).
24. National Nuclear Data Center (NNDC), http://www.nndc.bnl.gov/.
25. ICRU, " Tissue substitutes in radiation dosimetry and measurement.," ICRU Report No. 44 (International Commission on Radiation Units and Measurements, Bethesda, MD, 1989).
26. A. Cole, " Absorption of 20-eV to 50,000-eV electron beams in air and plastic.," Radiat. Res. RAREAE 0033-7587 38, 7-33 (1969). 10.2307/3572707
27. S. M. Goddu, R. W. Howell, and D. V. Rao, " Cellular dosimetry: Absorbed fractions for monoenergetic electron and alpha particle sources and S-values for radionuclides uniformly distributed in different cell compartments.," J. Nucl. Med. JNMEAQ 0161-5505 35, 303-316 (1994).
28. J. F. Ziegler, " Particle interactions with matter.," SRIM - The Stopping and Range of Ions in Matter; see http://www.srim.org.
29. S. J. Kennel, R. Boll, M. Stabin, H. M. Schuller, and S. Mirzadeh, " Radioimmunotherapy of micrometastases in lung with vascular targeted B 213 i.," Br. J. Cancer BJCAAI 0007-0920 80, 175-184 (1999). 10.1038/sj.bjc.6690337 (Pubitemid 29210104)
30. I. Kaplan, Nuclear Physics (Addison-Wesley, Reading, 1955).
31. H. Cember, Introduction to Health Physics, 3rd ed. (McGraw-Hill, New York, 1996).
32. G. Akabani, R. E. McLendon, D. D. Bigner, and M. R. Zalutsky, " Vascular targeted endoradiotherapy of tumors using alpha-particle-emitting compounds: Theoretical analysis.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 54, 1259-1275 (2002). 10.1016/S0360-3016(02)03794-X (Pubitemid 35292641)
33. D. Fukumura and R. K. Jain, " Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization.," Microvasc. Res. MIVRA6 0026-2862 74, 72-84 (2007). 10.1016/j.mvr.2007.05.003 (Pubitemid 350051025)
34. R. W. Howell and P. V. S. V. Neti, " Modeling multicellular response to nonuniform distributions of radioactivity: Differences in cellular response to self-dose and cross-dose.," Radiat. Res. RAREAE 0033-7587 163, 216-221 (2005). 10.1667/RR3290 (Pubitemid 40170772)
35. P. K. Leichner and C. S. Kwok, " Tumor dosimetry in radioimmunotherapy: Methods of calculation for beta particles.," Med. Phys. MPHYA6 0094-2405 20, 529-534 (1993). 10.1118/1.597048 (Pubitemid 23134002)
36. A. I. Kassis, " Radiotargeting agents for cancer therapy.," Expert Opinion on Drug Delivery 2, 981-991 (2005). 10.1517/17425247.2.6.981 1742-5247 (Pubitemid 41701198)
37. E. J. Hall, Radiobiology for the Radiologist, 5th ed. (Lippincott Williams & Wilkins, Philadelphia, 2000).