Management of skin toxicity during radiation therapy: A review of the evidence

Journal of Medical Imaging and Radiation Oncology

Volumn 54, Issue 3, 2010, Pages 264-279

  Kumar, S ^a   Juresic, E ^a   Barton, M ^a,b   Shafiq, J ^a,b  

^a LIVERPOOL HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Acute toxicity; Desquamation; Erythema; Radiation dermatitis; Skin care; Skin reaction skin toxicity

Indexed keywords

ALMOND OIL; ALOE VERA EXTRACT; ALPHA TOCOPHEROL; ASCORBIC ACID; BIAFINE; CALENDULA EXTRACT; CAVILON; CHAMOMILE; CORTICOSTEROID; CRYSTAL VIOLET; DEXPANTHENOL; DUODERM; EMOLLIENT AGENT; HYALURONIC ACID; HYDROCORTISONE; METHYLPREDNISOLONE; MOMETASONE FUROATE; PAWPAW EXTRACT; PLANT EXTRACT; ROSEHIP OIL; SUCRALFATE; SULFADIAZINE; TEA TREE OIL; TOPICAL AGENT; TROLAMINE; UNCLASSIFIED DRUG; WHEAT GRASS EXTRACT;

ARTICLE; AUSTRALIA AND NEW ZEALAND; BANDAGES AND DRESSINGS; BREAST; CLINICAL PRACTICE; CLINICAL TRIAL; CREAM; DISEASE SEVERITY; HUMAN; HYDROCOLLOID DRESSING; HYDROGEL; META ANALYSIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADIATION DERMATITIS; RADIOTHERAPY; SKIN CARE; SKIN TOXICITY; SYSTEMATIC REVIEW;

ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS; DERMATOLOGIC AGENTS; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; MALE; RADIODERMATITIS; RADIOTHERAPY, CONFORMAL; RISK ASSESSMENT; TREATMENT OUTCOME;

EID: 77953510752     PISSN: 17549477     EISSN: 17549485     Source Type: Journal    
DOI: 10.1111/j.1754-9485.2010.02170.x     Document Type: Article

References (40)

1. Glean E, Edwards S, Faithfull S et al. Intervention for acute radiotherapy induced skin reaction in cancer patients: The development of a clinical guideline recommended for use by the college of radiographers. J Radiother Pract 2000 2 (2 75 84.
2. Harper JL, Franklin LE, Jenrette JM, Aguero EG. Skin toxicity during breast irradiation: pathophysiology and management [Review]. South Med J 2004 (Oct 97 (10 989 993.
3. McQuestion M. Evidence-based skin care managment in radiation therapy. Semin Oncol Nurs 2006 22 (3 163 173.
4. Bostrom A, Lindman H, Swartling C, Berne B, Bergh J. Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 2001 (Jun 59 (3 257 265.
5. Liguori V, Guillemin C, Pesce GF, Mirimanoff RO, Bernier J. Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol 1997 (Feb 42 (2 155 161.
6. Lokkevik E, Skovlund E, Reitan J, Hannisdal E, Tanum G. Skin treatment with bepanthen cream versus no cream during radiotherapy. Acta Oncol 1996 35 (8 1021 1026.
7. Maiche A, Isokanga O, Grohn P. Skin Protection by sucralfate cream during electron beam therapy. Acta Oncol 1994 33 (2 201 203.
8. Pommier P, Gomez F, Sunyach MP, D'Hombres A, Carrie C, Montbarbon X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 2004 (Apr 15 22 (8 1447 1453.
9. D'haese S, Bate T, Claes S, Boone A, Vanvoorden V, Efficace F. Management of skin reactions during radiotherapy: a study of nursing practice. Eur J Cancer Care 2005 (Mar 14 (1 28 42.
10. Lavery BA. Skin care during radiotherapy: a survey of UK practice. Clin Oncol 1995 7 (3 184 187.
11. Campbell IR, Illingworth MH. Can patients wash during radiotherapy to the breast or chest wall? A randomized controlled trial. Clin Oncol 1992 (Mar 4 (2 78 82.
12. Roy I, Fortin A, Larochelle M. The impact of skin washing with water and soap during breast irradiation: a randomized study. Radiother Oncol 2001 (Mar 1 58 (3 333 339.
13. Westbury C, Hines F, Hawkes E, Ashley S, Brada M. Advice on hair and scalp care during cranial radiotherapy: a prospective randomized trial. Radiother Oncol 2000 (Feb 1 54 (2 109 116.
14. Olsen DL, Raub WJ, Bradley C, Johnson M, Macias JL, Love V, et al. The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol Nurs Forum 2001 28 (3 543 547.
15. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999 (Oct 1 49: 823 828.
16. Williams MS, Burk M, Loprinzi CL et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996 (Sep 1 36 (2 345 349.
17. Heggie S, Bryant GP, Tripcony L et al. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs 2002 (Dec 25 (6 442 451.
18. Delaney G, Fisher R, Hook C, Barton M. Sucralfate cream in the management of moist desquamation during radiotherapy. Australas Radiol 1997 (Aug 41 (3 270 275.
19. Wells M, Macmillan M, Raab G et al. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Radiother Oncol 2004 (Nov 73 (2 153 162.
20. Fisher J, Scott C, Stevens R et al. Randomized phase III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys 2000 (Dec 1 48 (5 1307 1310.
21. Szumacher E, Wighton A, Franssen E et al. Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy. Int J Radiat Oncol Biol Phys 2001 (Sep 1 51 (1 81 6.
22. Schmuth M, Wimmer MA, Hofer S et al. Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Br J Dermatol 2002 (Jun 146 (6 983 991.
23. Halperin EC, Gaspar L, George S, Darr D, Pinnell S. A double-blind randomised prospective trial to evaluate topical vitamin C solution of radiation dermatitis. Int J Radiat Oncol Biol Phys 1993 26 (3 413 416.
24. Graham P, Browne L, Capp A et al. Randomized, paired comparison of No-Sting Barrier Film versus sorbolene cream (10% glycerine) skin care during postmastectomy irradiation. Int J Radiat Oncol Biol Phys 2004 (Jan 1 58 (1 241 246.
25. Vuong T, Franco E, Lehnert S et al. Silver leaf nylon dressing to prevent radiation dermatitis in patients undergoing chemotherapy and external beam radiotherapy to the perineum. Int J Radiat Oncol Biol Phys 2004 (Jul 1 59 (3 809 814.
26. Wheat J, Currie G, Coulter K. Management of acute radiation skin toxicity with wheatgrass extract in breast radiation therapy: pilot study. Aust J Med Herb 2007 19 (2 77 0.
27. Elliott EA, Wright JR, Swann RS et al. Phase III trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99-13. J Clin Oncol 2006 (May 1 24 (13 2092 2097.
28. Potera ME, Lookingbill DP, Stryker JA. Prophylaxis of radiation dermatitis with topical cortisone cream. Radiother Oncol 1982 143: 775 777.
29. See A, Wright S, Denham JW. A pilot study of dermofilm in acute radiation-induced desquamative skin reactions. Clin Oncol 1998 10 (3 182 185.
30. MacBride SKM, Wells MEMBR, Hornsby CB, Sharp LPMR, Finnila KR, Downie LB. A case study to evaluate a new soft silicone dressing, Mepilex Lite, for patients with radiation skin reactions. Cancer Nurs 2008 (Jan 31 (1 E8 14.
31. Margolin SG, Breneman JC, Denman DL, LaChapelle P, Weckbach L, Aron BS. Management of radiation-induced moist skin desquamation using hydrocolloid dressing (Published erratum appears in Cancer Nurs 1990 (Aug); 13 (4): 267]. Cancer Nurs 1990 (Apr 13 (2 71 80.
32. Mak SS, Lolassiotis A, Wan WM, Lee IY, Chan ES. The effects of hydrocolloid dressing and gentian violet on radiation-induced moist desquamation wound healing. Cancer Nurs 2000 (Jun 23 (3 220 229.
33. Gollins S, Gaffney C, Slade S, Swindell R. RCT on gentian violet versus a hydrogel dressing for radiotherapy-induced moist skin desquamation. J Wound Care 2008 (Jun 17 (6 268.
34. Kedge EM. A systematic review to investigate the effectiveness and acceptability of interventions for moist desquamation in radiotherapy patients. Radiography 2009 (Aug 15 (3 247 257.
35. Gamble A, Gebski V, Boyages J. Solugel versus silver sulphadiazine cream in the treatment of radiation-induced moist desquamation. Prim Inten 1998 6 (3 102 107.
36. Shell JA, Stanutz F, Grimm J. Comparison of mositure vapor permeable (MVP) dressings to conventional dressings for management of radiation skin reactions. Oncol Nurs Forum 1986 13 (1 11 3.
37. Macmillan MS, Wells M, MacBride S, Raab GM, Munro A, MacDougall H. Randomized comparison of dry dressings versus hydrogel in management of radiation-induced moist desquamation. Int J Radiat Oncol Biol Phys 2007 (Jul 1 68 (3 864 872.
38. Bain G, Kuwahata H, Raymond B, Foster R. Teatree/hydrogel dressings used in wound care. A repeated measures comparitive study of tee tree oil and a paw paw cream dressings. Rural Industries Research and Development Corporation, 2005. [Cited 28 Oct 2009.] Available from URL: http://www.burnaid.com/trials- research/TTO-hydrogel-dressing-radiotherapy.pdf
39. Richardson J, Smith JE, McIntyre M, Thomas R, Pilkington K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. Clin Oncol 2005 (Sep 17 (6 478 484.
40. Korinko A, Yurick A. Maintaining skin integrity during radiation therapy. Am J Nurs 1997 (Feb 97 (2 40 4.