Geniposide prevents PC12 cells from peroxynitrite via the mitogen-activated protein kinase signaling pathway

Journal of Health Science

Volumn 56, Issue 2, 2010, Pages 195-199

  Yin, Fei ^a   Liu, Jianhui ^a   Xiao, He ^a   Kong, Shuzhen ^a  

^a Research Center of Medicinal Chemistry and Chemical Biology   (China)

Author keywords

Bcl 2; Geniposide; Mitogen activated protein kinase; Peroxynitrite

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; GENIPOSIDE; LINSIDOMINE; MITOGEN ACTIVATED PROTEIN KINASE; PEROXYNITRITE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; CELL STRAIN; COCULTURE; CONTROLLED STUDY; MOLECULAR PROBE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 77953491828     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.56.195     Document Type: Article

References (16)

1. Tabner, B. J., Turnbull, S., El-Agnaf, O. and Allsop, D. (2001) Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Curr. Top. Med. Chem., 1, 507-517.
2. Floyd, R. A. (1999) Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development. Free Radic. Biol. Med., 26, 1346-1355.
3. Ceballos, I., Javoy-Agid, F., Delacourte, A., Defossez, A., Nicole, A. and Sinet, P. M. (1990) Parkinson's disease and Alzheimer's disease: neurodegenerative disorders due to brain antioxidant system deficiency? Adv. Exp. Med. Biol., 264, 493-498.
4. Halliwell, B. (2001) Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging, 18, 685-716.
5. Kuo, W. H., Chou, F. P., Young, S. C., Chang, Y. C. and Wang, C. J. (2005) Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Toxicol. Appl. Pharmacol., 208, 155-162.
6. Yasuda, S., Idell, S. and Liu, M. C. (2007) Generation and release of nitrotyrosine o-sulfate by HepG2 human hepatoma cells upon SIN-1 stimulation: identification of SULT1A3 as the enzyme responsible. Biochem. J., 401, 497-503.
7. Haddad, J. J. (2007) The role of Bax/Bcl-2 and procaspase peptides in hypoxia/reperfusion-dependent regulation of MAPK (ERK): discordant proteomic effect of MAPK(p38). Protein Pept. Lett., 14, 361-371.
8. Larbi, A., Douziech, N., Fortin, C., Linteau, A., Dupuis, G. and Fulop, T., Jr. (2005) The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging. Immun. Ageing, 2, 6.
9. Koo, H. J., Lim, K. H., Jung, H. J. and Park, E. H. (2006) Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J. Ethnopharmacol., 103, 496-500.
10. Kuo, W. H., Wang, C. J., Young, S. C., Sun, Y. C., Chen, Y. J. and Chou, F. P. (2004) Differential induction of the expression of GST subunits by geniposide in rat hepatocytes. Pharmacology, 70, 15-22.
11. Wu, S. Y., Wang, G. F., Liu, Z. Q., Rao, J. J., Lu, L., Xu, W., Wu, S. G. and Zhang, J. J. (2009) Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol. Sin., 30, 202-208.
12. Liu, J. H., Yin, F., Guo, L. X., Deng, X. H. and Hu, Y. H. (2009) Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signaling pathway. Acta Pharmacol. Sin., 30, 159-165.
13. Lee, H. S., Wolfert, M. A., Zhang, Y. and Boons, G. J. (2006) The 2-aminogluconate isomer of rhizobium sin-1 lipid A can antagonize TNF-alpha production induced by enteric LPS. Chembiochem, 7, 140-148.
14. Holm, P., Kankaanranta, H., Metsa-Ketela, T. and Moilanen, E. (1998) Radical releasing properties of nitric oxide donors GEA 3162, SIN-1 and S-nitroso- N-acetylpenicillamine. Eur. J. Pharmacol., 346, 97-102.
15. Auddy, B., Ferreira, M., Blasina, F., Lafon, L., Arredondo, F., Dajas, F., Tripathi, P. C., Seal, T. and Mukherjee, B. (2003) Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases. J. Ethnopharmacol., 84, 131-138.
16. Castellani, R. J., Lee, H. G., Perry, G. and Smith, M. A. (2006) Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau. Am. J. Alzheimers Dis. Other Demen., 21, 126-130.