Determination of sitagliptinin human plasma using protein precipitation and tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 21, 2010, Pages 1817-1823

  Zeng, Wei ^a   Xu, Yang ^a   Constanzer, Marvin ^a   Woolf, Eric J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

DPP IV inhibitor; LC MS MS; Protein precipitation; Sitagliptin

Indexed keywords

ANALYTES; ATLANTIS; CALIBRATION STANDARD; HIGH ORGANIC; HUMAN CONTROL; HUMAN PLASMAS; HYDROPHILIC INTERACTION CHROMATOGRAPHY; INTRA-DAY ACCURACY; IONIZATION MODES; LC-MS/MS; LINEAR CALIBRATION; LOWER LIMIT OF QUANTITATIONS; MOBILE PHASE; MULTIPLE REACTION MONITORING; OFFLINE; PROTEIN PRECIPITATION; SILICA COLUMN; STABLE ISOTOPE LABELED INTERNAL STANDARDS; SUPERNATANTS; TANDEM MASS SPECTROMETRY; TURBO ION SPRAY;

CALIBRATION; COLUMN CHROMATOGRAPHY; HYDROPHILICITY; IONIZATION; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARTICLE DETECTORS; PHOSPHOLIPIDS; PLASMA (HUMAN); PLASMAS; SILICA;

PROTEINS;

ACETYLSALICYLIC ACID; ATORVASTATIN; DEXTROMETHORPHAN; DIPHENHYDRAMINE; IBUPROFEN; METFORMIN; PARACETAMOL; PHENIRAMINE; PHENYLEPHRINE; PHOSPHOLIPID; PIOGLITAZONE; SIMVASTATIN; SITAGLIPTIN; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; PYRAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ACCURACY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIZATION; PRECIPITATION; PRIORITY JOURNAL; QUALITY CONTROL; ROOM TEMPERATURE; TANDEM MASS SPECTROMETRY; BLOOD; CHEMISTRY; DRUG COMBINATION; PROCEDURES; REGRESSION ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TEMPERATURE;

CHEMICAL PRECIPITATION; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG STABILITY; DRUG THERAPY, COMBINATION; HUMANS; HYPOGLYCEMIC AGENTS; LEAST-SQUARES ANALYSIS; PYRAZINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TEMPERATURE; TRIAZOLES;

EID: 77953479865     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.05.013     Document Type: Article

References (21)

1. Kim D., Wang L., Beconi M., Eiermann G.J., Fisher M.H., He H., Hickey G.J., Kowalchick J.E., Leiting B., Lyons K., Marsilio F., McCann M.E., Patel R.A., Petrov A., Scapin G., Patel S.B., Sa Roy R., Wu J.K., Wyvratt M.J., Zhang B.B., Zhu L., Thornberry N.A., and Weber A.E. J. Med. Chem. 48 (2005) 141
2. Herman G.A., Bergman A.J., Liu F., Stenens C., Wang A.Q., Zeng W., Chen L., Snyder K.M., Hilliard D.A., Tanen M.R., Tanaka W.K., Meehan A.G., Lasseter K.C., Blum R.A., and Wagner J.A. J. Clin. Pharmacol. 46 (2006) 876
3. Zeng W., Musson D.G., Fisher A.L., and Wang A.Q. Rapid Commun. Mass Spectrom. 20 (2006) 1169
4. Zeng W., Musson D.G., Fisher A.L., Chen L., Schwartz M.S., Woolf E.J., and Wang A.Q. J. Pharm. Biomed. Anal. 48 (2008) 534
5. Xu Y., Willson K.J., Anderson M.D.G., Musson D.G., Miller-stern C.M., and Woolf E.J. J. Chromatogr. B 877 (2009) 1634
6. Nirogi R., Kandikere V., Mudigonda K., Komarneni P., Aleti R., and Boggavarapu R. Biomed. Chromatogr. 22 (2008) 214
7. Food and Drug Administration, U.S. Department of Health and Human Services. Guidance for Industry: Bioanalytical Method Validation (May 2001)
8. Xu Y., Xie W., Miller-Stein C.M., and Woolf E.J. Rapid Commun. Mass Spectrom. 23 (2009) 2195
9. Grumbach E.S., Wagrowski-Diehl D.M., Mazzeo J.R., Alden B., and Iraneta P.C. LCGC 22 (2004) 1010
10. Snyder L.R., Kirkland J.J., and Glajch J.L. Practical HPLC Method Development. 2nd ed. (1997), John Wiley & Sons, Inc., New York, NY p. 221
11. Dolan J.W., and Snyder L.R. Troubleshooting LC Systems (1989), Humana Press Inc., Totowa, NJ p. 268
12. Naidong W., Chen Y., Shou W., and Jiang X. J. Pharm. Biomed. Anal. 26 (2001) 753
13. Matuszewski B.K., Constanzer M.L., and Chavez-Eng C.M. Anal. Chem. 75 (2003) 3019
14. Wu S.T., Schoener D., and Jemal M. Rapid Commun. Mass Spectrom. 22 (2008) 2873
15. Ahnoff M., Murzer A., Lindmark B., and Jussila R. Proc. 51st ASMS Conf. Mass Spectrometry and Allied Topics. Montreal, Canada (2003)
16. Bennett P.K., and Van Horne K.C. AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition. Salt Lake City, UT (2003)
17. Van Horne K.C., and Bennett P.K. AAPS (American Association of Pharmaceutical Scientists) Annual Meeting and Exposition. Salt Lake City, UT (2003)
18. Pang L.Q., Liang Q.L., Wang Y.M., Ping L., and Luo G.A. J. Chromatogr. B 869 (2008) 118
19. Xia Y.Q., and Jemal M. Rapid Commun. Mass Spectrom. 23 (2009) 2125
20. Pucci V., Palma S.C., Alfieri A., Bonelli F., and Monteagudo E. J. Pharm. Biomed. Anal. 50 (2009) 867
21. Viswanathan C.T., Bansal S., Booth B., DeStefano A.J., Rose M.J., Sailstad J., Shah V.P., Skelly J.P., Swann P.G., and Weiner R. AAPS J. 9 1 (2007) E30