Animal models for schizophrenia via in utero gene transfer: Understanding roles for genetic susceptibility factors in brain development

Progress in Brain Research

Volumn 179, Issue C, 2009, Pages 9-15

  Kamiya, Atsushi ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Brain development; Genetic factor; In utero gene transfer; Schizophrenia

Indexed keywords

ANIMAL; ANIMAL EMBRYO; BRAIN; DISEASE MODEL; GENE TARGETING; GENE TRANSFER; GENE VECTOR; GENETIC PREDISPOSITION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METHODOLOGY; PATHOPHYSIOLOGY; REVIEW; SCHIZOPHRENIA;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; GENE TARGETING; GENE TRANSFER TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VECTORS; HUMANS; SCHIZOPHRENIA;

EID: 77953459529     PISSN: 00796123     EISSN: 18757855     Source Type: Book Series    
DOI: 10.1016/S0079-6123(09)17902-5     Document Type: Article

References (31)

1. Bai, J., Ramos, R. L., Paramasivam, M., Siddiqi, F., Ackman, J.B., & LoTurco, J. J. (2008). The role of DCX and LIS1 in migration through the lateral cortical stream of developing forebrain. Developmental Neuroscience, 30, 144-156.
2. Benes, F. M., Sorensen, I., & Bird, E. D. (1991). Reduced neuronal size in posterior hippocampus of schizophrenic patients. Schizophrenia Bulletin, 17, 597-608.
3. Borrell, V., Yoshimura, Y., & Callaway, E. M. (2005). Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation. Journal of Neuroscience Methods, 143, 151-158.
4. Duan, X., Chang, J. H., Ge, S., Faulkner, R. L., Kim, J. Y., Kitabatake, Y., et al. (2007). Disrupted-in-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell, 130, 1146-1158.
5. Fukuchi-Shimogori, T., & Grove, E. A. (2001). Neocortex patterning by the secreted signaling molecule FGF8. Science, 294, 1071-1074.
6. Gal, J. S., Morozov, Y. M., Ayoub, A. E., Chatterjee, M., Rakic, P., & Haydar, T. F. (2006). Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. Journal of Neuroscience, 26, 1045-1056.
7. Glantz, L. A., & Lewis, D. A. (2000). Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Archives of General Psychiatry, 57, 65-73.
8. Harrison, P. J., & Weinberger, D. R. (2005). Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Molecular Psychiatry, 10, 40-68.
9. Jaaro-Peled, H., Hayashi-Takagi, H., Seshadri, S., Kamiya, A., Brandon, J.N., & Sawa, A. (2009). Neurodevelopmental mechanisms of schizophrenia: Understanding disturbed postnatal brain maturation through NRG1-ERBB4 and DISC1. Trends in Neurosciences, 32(9), 485-495.
10. Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., et al. (2005). A schizophreniaassociated mutation of DISC1 perturbs cerebral cortex development. Nature Cell Biology, 7, 1167-1178.
11. Kamiya, A., Tomoda, T., Chang, J., Takaki, M., Zhan, C., Morita, M., et al. (2006). DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Human Molecular Genetics, 15, 3313-3323.
12. Kamiya, A., Tan, P. L., Kubo, K., Engelhard, C., Ishizuka, K., Kubo, A., et al. (2008). Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: A candidate for psychiatric illnesses. Archives in General Psychiatry, 65, 996-1006.
13. Langevin, L. M., Mattar, P., Scardigli, R., Roussigne, M., Logan, C., Blader, P., et al. (2007). Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalon. Developmental Dynamics, 236, 1273-1286.
14. Lewis, D. A., & Levitt, P. (2002). Schizophrenia as a disorder of neurodevelopment. Annual Review of Neuroscience, 25, 409-432.
15. Lewis, D. A., Volk, D. W., & Hashimoto, T. (2004). Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: A novel target for the treatment of working memory dysfunction. Psychopharmacology (Berl), 174, 143-150.
16. Manent, J. B., Wang, Y., Chang, Y., Paramasivam, M., & LoTurco, J. J. (2009). Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Nature Medicine, 15, 84-90.
17. Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., et al. (2009). Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell, 136, 1017-1031.
18. Matsuda, T., & Cepko, C. L. (2007). Controlled expression of transgenes introduced by in vivo electroporation. Proceedings of the National Academy of Sciences United States of America, 104, 1027-1032.
19. Miyagi, S., Saito, T., Mizutani, K., Masuyama, N., Gotoh, Y., Iwama, A., et al. (2004). The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells. Molecular Cell Biology, 24, 4207-4220.
20. Nakahira, E., & Yuasa, S. (2005). Neuronal generation, migration, and differentiation in the mouse hippocampal primoridium as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation. Journal of Comparative Neurology, 483, 329-340.
21. Owen, M. J., Craddock, N., & O'Donovan, M. C. (2005). Schizophrenia: Genes at last? Trends in Genetics, 21, 518-525.
22. Pierri, J. N., Volk, C. L., Auh, S., Sampson, A., & Lewis, D. A. (2001). Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia. Archives in General Psychiatry, 58, 466-473.
23. Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. (2005). The neurodevelopmental model of schizophrenia: Update 2005. Molecular Psychiatry, 10, 434-449.
24. Remedios, R., Huilgol, D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk, T., Hevner, R. F., et al. (2007). A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nature Neuroscience, 10, 1141-1150.
25. Sauvageot, C. M., & Stiles, C. D. (2002). Molecular mechanisms controlling cortical gliogenesis. Current Opinion in Neurobiology, 12, 244-249.
26. Shu, T., Ayala, R., Nguyen, M. D., Xie, Z., Gleeson, J. G., & Tsai, L. H. (2004). Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron, 44, 263-277.
27. Tabata, H., & Nakajima, K. (2001). Efficient in utero gene transfer system to the developing mouse brain using electroporation: Visualization of neuronal migration in the developing cortex. Neuroscience, 103, 865-872.
28. Uranova, N. A., Vostrikov, V. M., Vikhreva, O. V., Zimina, I.S., Kolomeets, N. S., & Orlovskaya, D. D. (2007). The role of oligodendrocyte pathology in schizophrenia. International Journal of Neuropsychopharmacology, 10, 537-545.
29. Wang, X., Qiu, R., Tsark, W., & Lu, Q. (2007). Rapid promoter analysis in developing mouse brain and genetic labeling of young neurons by doublecortin-DsRed-express. Journal of Neuroscience Research, 85, 3567-3573.
30. Yokota, Y., Ring, C., Cheung, R., Pevny, L., & Anton, E. S. (2007). Nap1-regulated neuronal cytoskeletal dynamics is essential for the final differentiation of neurons in cerebral cortex. Neuron, 54, 429-445.
31. Young-Pearse, T. L., Bai, J., Chang, R., Zheng, J. B., LoTurco, J. J., & Selkoe, D. J. (2007). A critical function for betaamyloid precursor protein in neuronal migration revealed by in utero RNA interference. Journal of Neuroscience, 27, 14459-14469.