Dendrimer a versatile polymer in drug delivery

Asian Journal of Pharmaceutics

Volumn 3, Issue 3, 2009, Pages 178-187

  Singh, Shakti ^a,b   Lohiya, G K ^a   Limburkar, P P ^a   Dharbale, N B ^a   Mourya, V K ^a  

^a GOVERNMENT COLLEGE OF PHARMACY   (India)

^b Bajaj Auto Limited   (India)

Author keywords

Biomaterials; Dendrimer; Drug delivery; Nanoscopic drug carriers; Polyamidoamine (PAMAM) dendrimer

Indexed keywords

COSMETIC; CROSS LINKING REAGENT; DENDRIMER; DRUG CARRIER; INDOMETACIN; NANOCOMPOSITE; NIFEDIPINE; PILOCARPINE; POLYAMIDOAMINE; TECHNETIUM 99M;

BIOCOMPATIBILITY; BIOTECHNOLOGY; CATALYSIS; CHEMICAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE; ENCAPSULATION; FLOW KINETICS; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; GENETIC TRANSFECTION; INFRARED SPECTROSCOPY; NANODEVICE; NANOTECHNOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; POLYMERIZATION; REVIEW; ULTRAVIOLET SPECTROSCOPY; VISCOSITY; X RAY CRYSTALLOGRAPHY;

EID: 77953451195     PISSN: 09738398     EISSN: 1998409X     Source Type: Journal    
DOI: 10.4103/0973-8398.56295     Document Type: Review

References (66)

1. Gupta U, Agashe HB, Jain NK. Polypropylene Imine: Dendrimer Mediated Solubility Enhancement: Effect of pH and Functional Groups of Hydrophobes. J Pharm Pharmaceut Sci 2007;10:358-367
2. Devarakonda B, Hill RA, Liebenberg W, Brits M, De Villiers MM. Comparison of aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins. Int J Pharm 2005;300:193-209.
3. Devarakonda B, Li N, De Villiers M. Effect of Polyamidoamine (PAMAM) Dendrimers on the in vitro release of water-insoluble nifedipine from aqueous gels. AAPS PharmSciTech 2005;6:504-512
4. Liu M, Kono K, Frechet JM. Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents. J Control Release 2000;65:121-131
5. D̀Emanuele A, Jevprasesphant JP, Penny J, Attwood D. The use of a dendrimer propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Control Release 2004;95:447-453
6. Milhem OM, Myles C, McKeown NB, D'Emanuele A. Polyamidoamine Starburst dendrimers as solubility enhancers. Int J Pharm 2000;197:239-241
7. Beezer AE, King AS, Martin IK, Mitchel JC, Twyman LJ, Wain CF. Dendrimers as potential drug carriers;encapsulation of acidic hydrophobes within water soluble PAMAM derivatives. Tetrahedron 2003;59:3873-3880
8. Khopade AJ, Caruso F, Tripathi P, Nagaich S, Jain NK. Effect of dendrimer on entrapment and release of bioactive from liposomes. Int J Pharm 2002;232:157-162
9. Chauhan AS, Sridevi S, Chalasani KB, Jain AK, Jain SK, Jain NK, et al. Dendrimer-mediated transdermal delivery: Enhanced bioavailability of indomethacin. J Cont Rel 2003;90:335-343
10. Asthana A, Chauhan AS, Diwan PV, Jain NK. Poly (amidoamine) (PAMAM) Dendritic Nanostructures for Controlled Site-specific Delivery of Acidic Anti-Inflammatory Active Ingredient. AAPS PharmSciTech 2005;13:200-208
11. Bhadra D, Bhadra S, Jain S, Jain NK. A PEGylated dendritic nanoparticulate carrier of fluorouracil. Int J Pharm 2003;257:111-124
12. Tomalia DA. Dendritic macromolecules: Synthesis of starburst dendrimers. Macromolecules 1986;19:2466-2467
13. Kim C. Advanced pharmaceutics: Physicochemical principles. New York: CRC Press;p. 409-412
14. Esfand R, Tomalia DA. Poly (amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications. Drug Discov Today 2001;6:427-436
15. Chauhan AS, Jain NK, Diwan PS, Khopade AS. Solubility enhancement of indimethacin with PAMAM dendrimer and targeting to inflammatory regions of arthritic rats. J Drug Targeting 2004;12:575-583
16. Tomalia DA. Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog Polym Sci 2005;30:294-324.
17. Jain NK. Advances in controlled and novel drug delivery: Delhi: CBS Publishers and Distributors;2000. p. 361-370
18. Available from: http://www.dnanotech.com. [last accessed January 2006].
19. Available from: http://www.pubmed.com. [last accessed March 2000].
20. Available from: http://www.uspto.gov. [last accessed September 2005].
21. Rutt SJ, Maebus SB. 3rd annual BBC conference on nano/bio convergence. Cambridge;Foley and Lardner LLP;2004. p. 1-5.
22. Pushkar S, Philip A, and Pathak K. Dendrimers: Nanotechnology derived novel polymers in drug delivery. Ind J Pharm Edu Res 2006;40:153-157
23. Barbara K, Maria B. Dendrimers: Properties and application. Acta Biochemica Polinica 2001;48:199-208.
24. Newkome GR. Dendrimers and dendrons: Concept, Synthesis, Applications. New York: Wiley- VCH;2001. p. 44, 51, 68, 61
25. Tomalia DA, Svenson S. Dendritic macromolecules: Synthesis of starburst dendrimers. Macromolecules 1986;19:2466-2467
26. Peterson J, Ebber A, Veiko A. Synthesis and CZE analysis of PAMAM dendrimers with an ethylenediamine core. Proc Estonian Acad Sci Chem 2001;50:156-166
27. Denkewalter RG. Macromolecular highly branched diaminocarboxylic acids. Chem Abstr 1984;100:103907.
28. Bezouska K. Design, functional evaluation and biomedical applications of carbohydrate dendrimers (glycodendrimers). J Biotechnol 2002;90:269-290
29. Grinstaff MW. Biodendrimers: New polymeric biomaterials for tissue engineering. Chemistry 2002;8:2839-2846
30. Bhadra S, Bhadra D, Jain NK. PEGylated Dendritic nanoparticulate carrier of fluorouracil. Int J Pharm 2003;257:111-124
31. Istvan JM, Scott W, Baker JR. Acetylation of Poly (amidoamine) Dendrimers. Macromolecules 2003;36:5526-5529
32. Uekama K, Chihara, Y, Koki, W, Enhancement of gene transfer activity mediated by mannosylated dendrimer/alpha cyclodextrin activity conjugate. J Control Release 2006;116:64-74.
33. Jevprasesphant R, Penny F, Attwood D, McKeown NB. Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity. Pharma Res 2003;20:1543-1550
34. Svenson S, Tomalia DA. Dendrimer Biomedical applications reflection on field. Adv Drug Del Rev 2005;57:2106-2129
35. Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Del Rev 2005;57:2215-2237
36. Frechet JM, Tomalia DA. Dendrimers and other dendritic polymers, Wiley series in polymer science. John Wiley and Sons. 2004. p. 256-260
37. Achar S. Organoplatinum dendrimers formed by oxidative addition. Angew Chem Int Ed Engl 1994;33:847-849
38. Liu Z, Michael A. FT-IRAS spectroscopic studies of the interaction of avidin with biotynylated dendrimer surfaces. Colloids and surfaces. Biointerfaces 2004;35:197-203.
39. Miller TM, Kwock EW, Neenan TX. Synthesis of four generations of monodisperse aryl ester dendrimers based on 1, 3,5-benzenetricarboxylic acid. Macromolecules 1992;25:3143-3148
40. Wilken R, Adams J. End group dynamics of fluorescently labeled dendrimers. Macromol Rapid Commun 1997;18:659-665 (Pubitemid 127475919)
41. Hummelen JC, Van JL Dongen, Meijer EW. Electrospray mass spectrometry of poly (propylene imine) dendrimers-the issue of dendritic purity or polydispersity. Chem Eur J 1997;3:1489-1493
42. Rietveld IB, Smit AM. Colligative and viscosity properties of poly (propylene imine) dendrimers in methanol. Macromolecules 1999;32:4608-4614
43. Hofkens J, Verheijen W, Shukla R. Detection of a single dendrimer macromolecule with a fluorescent dihydropyrrolopyrroledione (DPP) core embedded in a thin polystyrene polymer film. Macromolecules 1998;31:4493-4497
44. Zeng F. Supramolecular polymer chemistry: Design Synthesis, characterization and kinetics, thermodynamics, and fidelity of formation of self assembeled dendrimers. Tetrahedron 2002;58:825-843
45. Bossman AW, Janseen Meijer EW. Five generations of nitroxylfunctionalized dendrimers, Macromolecules 1997;30:3606-3611
46. Brothers HM. Slab gel and capillary electrophoresis characterization of poly amidoamine dendrimers. J Chromatogram 1998;A814:233-246
47. Shi X, Patri AK, Lesniak W, Islam MT, Zhang C, Baker JR Jr, et al. Analysis of poly (amidoamine) succinamic acid dendrimers by slab-gel electrophoresis and capillary sone electrophoresis. Electrophoresis 2005;26:2960-2967
48. Caminade AM. Characterization of dendrimers, Adv Drug Deliv Rev 2005;57:2130-2146
49. Yang H, Kao WJ. Dendrimers for pharmaceutical and biomedical applications. J Biomater Sci Polymer Edn 2006;17:3-19.
50. Zhuo RX. In vitro release of 5-fluorouracil with cyclic core dendritic polymer. J Control Release 1999;57:249-257
51. Tansey W, Cao XY, Pasuelo MJ, Wallace S. Synthesis and characterization of branched poly (l-lutamic acid) as a biodegradable drug carrier. J Control Release 2004;94:39-51.
52. Devarakonda B, Hill RA, Villiers MM. The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine. Int J Pharm 2004;284:133-140
53. Chauhan AS, Jain AK, Jain NK. Dendrimer-mediated transdermal delivery: Enhanced bioavailability of indomethacin. J Control Release 2003;90:335-343
54. Wang ZX, Yoshiaki I, Yoshifumi H. Mechanism of enhancement of effect of dendrimers on transdermal permeation through polyhydroxyalkanoate matrix. J Bioscience Bioeng 2003;96:537-540
55. Cheng YY, Man N, Xu TW. Transdermal delivery of nonsteroidal anti inflammatory drugs mediated by PAMAM dendrimers. J Pharm Sci 2006;96:595-602.
56. Vandamme TF, Broberck L. PAMAM dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. J Control Release 2005;102:23-38.
57. Available from: http://www.starpharma.com.[last accessed December 2007].
58. Davis FJ. Polymer Chemistry A practical approach G.R. Oxford: Oxford University Press;2004. p. 188-198
59. Bielinska AU, Chen C, Johnson J, Baker JR. DNA complexing with polyamidoamine dendrimers: Implications for transfection. Bioconjug Chem 1999;10:843-850
60. Choi JC, Nam K, Park JY. Enhanced transfection efficiency of PAMAM dendrimers modification with L-arginine. J Control Release 2004;99:445-456
61. Fahlvik, Simon. Ultrafine lightly coated superparamagnetic particles for MRI .US patent 4606907.
62. Sheela DK, Michael A, Steven W. Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. MAGMA 2001;12:104-113
63. Svenson S, Tomalia DA. Dendrimer Biomedical applications reflection on field. Adv Drug Del Rev 2005;57:2106-2129
64. Chakib H, Rainer H. Hyperbranched polymers as platforms for catalysts. Top Organomet Chem 2006;20:149-176
65. Esumi K, Matsumoto T, Seto Y. Preparation of gold-gold/silver-dendrimer nanocomposites in the presence of benzoin in ethanol by UV irradiation. J Colloid Interface Sci 2005;284:199-203.
66. Istvan JM, Thommey PT, Chandan B. Poly (amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy. J Med Chem 2005;48:5892-5899