Preparation and in vitro and in vivo evaluation of silymarin self-microemulsifying concentrated microemulsion

Chinese Journal of New Drugs

Volumn 19, Issue 5, 2010, Pages 422-426

  Li, Xin Ru ^a   Yuan, Quan ^b   Li, Xiao Yan ^a   Zhou, Yan Xia ^a   Liu, Yan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Beijing DMS Pharma Ltd   (China)

Author keywords

Bioavailability; In vitro release; Self microemulsifying concentrated microemulsion; Silymarin

Indexed keywords

SILYMARIN;

AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG STABILITY; IN VITRO STUDY; IN VIVO STUDY; MICROEMULSION; NONHUMAN; TRANSMISSION ELECTRON MICROSCOPY;

EID: 77953447669     PISSN: 10033734     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. EL-SAMAUGY MS, AFIFI NN, MAHMOUD EA. Increasing bioavailability of Silymarin using a buccal liposomal delivery system: Preparation and experimental design investigation [J]. Int J Pharm, 2006,308(1-2):140-148.
2. CHARMAN WN. Lipids, lipophilic drugs, and oral drug delivery some emerging concepts [J]. J Pharm Sci, 2000,89(8):967-978.
3. GERSHANIKA T, BENITA S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs [J]. Eur J Pharm Biopharm, 2000,50(2):179-188.
4. LIU Y, ZHANG P, FENG NP ,et al. Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin[J]. Int J Pharm, 2009,365(1-2):136-142.
5. HOLM R, PORTER C, EDWARDS G, et al. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems(SMEDDS) containing structured triglycerides[J]. Eur J Pharm Sci, 2003,20(1):91-97.
6. ARAYA H, TOMITA M, HAYASHI M. The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds [J]. Int J Pharm, 2005,305(1-2):61-74.