Transconjunctival sutureless vitrectomy with tissue plasminogen activator, gas and intravitreal bevacizumab in the management of predominantly hemorrhagic age-related macular degeneration

Clinical Ophthalmology

Volumn 4, Issue 1, 2010, Pages 67-72

  Arias, Luis ^a,b   Monés, Jordi ^a  

^a CENTRO MÉDICO TEKNON   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Hemorrhagic age related macular degeneration; Intravitreal bevacizumab; Tissue plasminogen activator; Transconjunctival sutureless vitrectomy

Indexed keywords

ANTICOAGULANT AGENT; BEVACIZUMAB; SULFUR HEXAFLUORIDE; TISSUE PLASMINOGEN ACTIVATOR; WARFARIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; EARLY INTERVENTION; FEMALE; FOLLOW UP; HEART ARRHYTHMIA; HUMAN; MALE; PATIENT SAFETY; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA HEMORRHAGE; RETINA TEAR; SCOTOMA; TRANSCONJUNCTIVAL SUTURELESS VITRECTOMY; TREATMENT OUTCOME; VISUAL ACUITY; VITRECTOMY; VITREOUS HEMORRHAGE;

EID: 77953436001     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: 10.2147/opth.s8635     Document Type: Article

References (16)

1. Hochman MA, Seery CM, Zarbin MA. Pathophysiology and management of subretinal hemorrhage. Surv Ophthalmol. 1997;42:195-213.
2. Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355: 1419-1431.
3. Bressler NM, Bressler SB, Childs AL, et al. Submacular Surgery Trials (SST) Research Group. Surgery for hemorrhagic choroidal neovascular lesions of age-related macular degeneration: ophthalmic findings: SST report no. 13. Ophthalmology. 2004;111:1993-2006.
4. Ahmad S, Bearelly S, Stinnett SS, Cooney MJ, Fekrat S. Photodynamic therapy for predominantly hemorrhagic lesions in neovascular age-related macular degeneration. Am J Ophthalmol. 2008;145: 1052-1057.
5. Peyman GA, Nelson NC Jr, Alturki W, et al. Tissue plasminogen activating factor assisted removal of subretinal hemorrhage. Ophthalmic Surg. 1991;22:575-582.
6. Haupert CL, McCuen BW II, Jaffe GJ, et al. Pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and fluid-gas exchange for displacement of thick submacular hemorrhage in age-related macular degeneration. Am J Ophthalmol. 2001;131:208-215.
7. Singh RP, Patel C, Sears JE. Management of subretinal macular haemorrhage by direct administration of tissue plasminogen activator. Br J Ophthalmol. 2006;90:429-431.
8. Olivier S, Chow DR, Packo KH, MacCumber MW, Awh CC. Subretinal recombinant tissue plasminogen activator injection and pneumatic displacement of thick submacular hemorrhage in age-related macular degeneration. Ophthalmology. 2004;111:1201-1208.
9. Hassan AS, Johnson MW, Schneiderman TE, et al. Management of submacular hemorrhage with intravitreous tissue plasminogen activator injection and pneumatic displacement. Ophthalmology. 1999;106: 1900-1906.
10. Chen CY, Hooper C, Chiu D, et al. Management of submacular hemorrhage with intravitreal injection of tissue plasminogen activator and expansile gas. Retina. 2007;27:321-328.
11. Ohji M, Saito Y, Hayashi A, Lewis JM, Tano Y. Pneumatic displacement of subretinal hemorrhage without tissue plasminogen activator. Arch Ophthalmol. 1998;116:1326-1332.
12. Oshima Y, Ohji M, Tano Y. Pars plana vitrectomy with peripheral retinotomy after injection of preoperative intravitreal tissue plasminogen activator: a modified procedure to drain massive subretinal haemorrhage. Br J Ophthalmol. 2007;91:193-198.
13. Meyer CH, Scholl HP, Eter N, Helb HM, Holz FG. Combined treatment of acute subretinal haemorrhages with intravitreal recombined tissue plasminogen activator, expansile gas and bevacizumab: a retrospective pilot study. Acta Ophthalmol. 2008;86:490-494.
14. Tilanus MA, Vaandrager W, Cuypers MH, Verbeek AM, Hoyng CB. Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2000;238:482-485.
15. Lüke M, Januschowski K, Warga M, et al. The retinal tolerance to bevacizumab in co-application with a recombinant tissue plasminogen activator. Br J Ophthalmol. 2007;91:1077-1082.
16. Biester S, Bartz-Schmidt KU, Gelisken F. Retinal pigment epithelial tear after subretinal rtPA and intravitreal air for the displacement of a large submacular hemorrhage. Retinal Cases and Brief Reports. 2009;3(1):62-63.