Development of indomethacin sustained release microcapsules using ethyl cellulose and hydroxy propyl methyl cellulose phthalate by O/W emulsification

Dhaka University Journal of Pharmaceutical Sciences

Volumn 7, Issue 1, 2008, Pages 83-88

  Kamal, Md Abu Hena Mostafa ^a   Ahmed, Maruf ^a   Wahed, Mir Imam Ibne ^a   Amran, Md Shah ^b   Shaheen, Sharif Md ^a   Rashid, Mamunur ^a   Anwar Ul Islam, Md ^a  

^a UNIVERSITY OF RAJSHAHI   (Bangladesh)

^b UNIVERSITY OF DHAKA   (Bangladesh)

Author keywords

EC; Higuchi order; HPMCP; Indomethacin; Microcapsule; Sustained release

Indexed keywords

ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; INDOMETACIN; PHOSPHATE;

ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG FORMULATION; DRUG SOLUBILITY; EVAPORATION; IN VITRO STUDY; MICROCAPSULE; MICROEMULSION; MICROENCAPSULATION; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; REPRODUCIBILITY; SUSTAINED RELEASE FORMULATION;

EID: 77953427373     PISSN: 18161820     EISSN: 18161839     Source Type: Journal    
DOI: 10.3329/dujps.v7i1.1223     Document Type: Article

References (14)

1. Bakan, J.L. 1986. In: The Theory and Practice of Industrial Pharmacy. (Lachman, L., Lieberman, H.A. and Kanig, J.L., Eds.), Lea and Febiger, Philadelphia, Chapter 13-part III, pp. 412-429.
2. Bodmeier, R. and Wang, J. 1993. Microencapsulation of Drugs with Aqueous Colloidal Polymer Dispersions. J. Pharm. Sci. 82, 191-94.
3. 2-Based Microencapsulation. Langmuir 21, 379-385.
4. Rowe, J.S. and Carless, J.E. 1981. Comparison of the In Vitro Dissolution Behaviour of Various Indomethacin Formulations with Their In vivo Bioavailability. J. Pharm. Pharmacol. 33, 561-564.
5. Khanfar, M.S., Salem, M.S., Najib, N.M. and Pillai, G.K. 1997. Dissolution Behaviour of Sustained Release Formulations of Indomethacin with Eudragit RS. Acta. Pharm. Hung. 67 (6), 235-239.
6. Tiyaboonchai, W. and Ritthidej, G.C. 2003. Development of Indomethacin Sustained Release Microcapsules Using Chitosan-Carboxymethylcellulose Complex Coacervation. Songklanakarin J. Sci. Technol. 25, 245-254.
7. Flower, R.J., Moncada, S. and Vane, J.R. 1990. Indomethacin. In: Goodman and Gilman's The Pharmacological Basis of Therapeutics (Gilman, A.G. et al. Eds.), Macmillan Publishing Co., New York, pp. 695-97.
8. Jalil, R. and Nixon, J.R. 1990. Microencapsulation Using Poly (L-Lactic Acid) II: Preparative Variables Affecting Microcapsule Properties. J. Microencapsul. 7, 25-39.
9. Zour, E. and Lausier, J.M. 1984. Dissolution Studies of Microencapsulated Indomethacin; Effect of Method and Medium on Dissolution. J. Microencapsul. 1, 47-51.
10. Martin, A. 1993. Colloids. In: Physical Pharmacy: Physical and Chemical Principles in Pharmaceutical Sciences. 4th ed., Lea and Febiger, Philadelphia, pp. 393-422, 453-476.
11. Baveja, S.K., Ranga Rao K.V. and Padmalatha Devi K. 1987. Zero-order release hydrophilic matrix tablets of 2b-adrenergic blockers. Int. J. Pharm. 39, 39-45.
12. Schwartz, J.B., Simonelli, A.P. and Higuchi, W.I. 1968. Drug release from wax matrices. I. Analysis of data with first-order kinetics and with the diffusion-controlled model. J. Pharm. Sci. 57, 274-277.
13. Lee, H.J., Lee, M.H. and Shim, C.K. 1984. Preparation and Evaluation of Ethyl Cellulose Microcapsules of Indomethacin. Arch. Pharm. Res. 7, 33-40.
14. Green, J.A. 1984. Indomethacin sustained-release? Drug Intell. Clin. Pharm. 18, 1004-1007.