Development of agglomerated crystals of ascorbic acid by the spherical crystallization technique for direct tableting, and evaluation of their compactibilities

KONA Powder and Particle Journal

Volumn 20, Issue March, 2002, Pages 251-262

  Kawashima, Yoshiaki ^a   Imai, Misato ^a   Takeuchi, Hirofumi ^a   Yamamoto, Hiromitsu ^a   Kamiya, Kazunori ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; COMPACTION; ORGANIC ACIDS; STRESS RELAXATION; TENSILE STRENGTH;

COMPRESSION SPEED; DYNAMIC COMPACTION; ELASTIC RECOVERY; SPHERICAL CRYSTALLIZATION; TABLETING;

ASCORBIC ACID;

EID: 77953424087     PISSN: 02884534     EISSN: 21875537     Source Type: Journal    
DOI: 10.14356/kona.2002028     Document Type: Article

References (14)

1. Kawashima, Y. "New Processes-Application of Spherical Crystallization to Particulate Design of Pharmaceuticals for Direct Tabletting and Coating, and New Drug Delivery Systems," Powder Technology and Pharmaceutical Process, edited by D. Chulia et al., 493-512, Elsevier (1994).
2. Kawakita, K. "Compression of Powder," Kagaku, 26, 149 (1956).
3. Kuno, H. Funtai (Powder Theory and Application), ed. by G. Jimbo et al., Maruzen, Tokyo, p. 342 (1979).
4. Heckel, R. W. "Density-pressure Relationships in Powder Compaction," Trans. Met. Soc. AIME, 221, 671 (1961).
5. Heckel, R. W. "An Analysis of Powder Compaction Phenomena," Trans. Met. Soc. AIME, 221, 1001 (1961).
6. Kawashima, Y., F. Cui, H. Takeuchi, T. Niwa, T. Hino and K. Kiuchi. "Improved Static Compression Behaviors and Tablettabilities of Spherically Agglomerated Crystals Produced by the Spherical Crystallization Technique with a Two-solvent System," Pharm. Res., 12 (7), 1040-1044 (1995).
7. Peleg, M. and R. Moreyra. "Effect of Moisture on the Stress Relaxation Pattern of Compacted Powders," Powder Technol., 23, 277 (1979).
8. Danjyo, K., A. Hiramatsu and A. Otsuka. "Effect of Punch Velocity on the Compressibility and Stress Relaxation of Particles and Granules," J. Soc. Powder Technol. Japan, 35, 662-670 (1998).
9. Armstrong, N. A. and R. F. Haines-Nutt. "Elastic Recovery and Surface Area Changes in Compacted Powder Systems," Powder Technol., 9, 287-290 (1974).
10. Fell, J. T. and J. M. Newton. "Determination of Tablet Strength by the Diametral-compression Test," J. Pharm. Sci. 5, 688-691 (1970).
11. Doelker, E. "Assessment of Powder Compaction," Powder Technology and Pharmaceutical Process, edited by D. Chulia et al., 403-512, Elsevier (1994).
12. Cutt, T., J. T. Fell, P. J. Rue and M. S. Spring. "Granulation and Compaction of a Model System, II Stress Relaxation," Int. J. Pharm., 39, 157-161 (1987).
13. Kawashima, Y., F. Cui, H. Takeuchi, T. Niwa, T. Hino and K. Kiuchi. "Improvements in Flowability and Compressibility of Pharmaceutical Crystals for Direct Tabletting by Spherical Crystallization with a Two-solvent System," Powder Technol., 78, 151-157 (1994).
14. Kojima, S. "ICH Guideline for Residual Solvents in Drugs," PHARM TECH JAPAN, 16 (5), 7-24 (2000).