An HPLC-ESI-MS method for the determination of propranolol in human plasma and its application to pharmacokinetic studies

Asian Journal of Pharmaceutical Sciences

Volumn 4, Issue 3, 2009, Pages 169-177

  Zhang, Jing ^a   Ding, Li ^a   Wen, Aidong ^a,b   Wu, Fei ^a   Sun, Luning ^a   Yang, Lin ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HPLC ESI MS; Pharmacokinetics; Propranolol

Indexed keywords

ACETIC ACID ETHYL ESTER; AMMONIUM ACETATE; FORMIC ACID; METHANOL; PROPRANOLOL;

ARTICLE; BLOOD LEVEL; DOPING; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION MONITORING; PLASMA; SENSITIVITY ANALYSIS;

EID: 77953420451     PISSN: 18180876     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. A. J. Boakes, B. N. C.Prichard. The effect of AH 5158, pindolol, propranolol, D-propranolol on acute exercise tolerance in angina pectoris. Br. J. Pharmacol., 1973, 47: 673-674.
2. A. Mitrani, M. Oettinger, E. G. Alunader, et al. Use of propranolol in dysfunctional labour. Br. J. Obstet. Gynacol.,1975, 82: 651-655.
3. K. L. Granville-Grossman, P. Turner. The effect of propronolol on anxiety. Lancet, 1966, 1: 788-790.
4. J. A. Murillo-Pulgarin, A. Alanon-Molina, P. Fernandez-Lopez. Simultaneous determination of atenolol, propranolol, dipyridamole and amiloride by means of non-linear variable-angle synchronous fluorescence spectrometry. Anal. Chim. Acta, 1998, 370: 9-18.
5. C. Rodriguez Bueno, Dopaje, Mc-Graw Hill, Madrid, 1992.
6. T. Walle, T. Fagan, D. Conrad, et al. Presystemic and systemic glucosonidation of propranolol. Clin. Pharmacol. Ther, 1979, 76: 167-172.
7. J. A. P.Douglas, N. S. Baber, A. Lee. Once daily propranolol in the treatment of mild to moderate hypertension. Eur. J. Pharmacol., 1978, 14: 163-166.
8. A. Halkin, D. Vered, A. Saginer, et al. Once daily administration of sustained release propranolol capsules in the treatment of angina pectoris. Eur. J. Clin. Pharmacol., 1979, 16: 387-391.
9. J. S. Floras, J. V. Jones, M. O. Hassan, et al. Ambulatory blood pressure during once-daily randomized double blind administration of atenolol, metoprolol, pindolol, and slow release propranolol. Br. Med. J., 1982, 285: 1387-1392.
10. B. G. Charles, P. J. Ravenscroft, P. J. Renshaw. Comparative pharmacokinetics of propranolol and h-hydroxypropranolol using conventional and long acting propranolol. J. Pharm. Pharmacol., 1982, 34: 481-484.
11. J. G. Wagner. Propranolol: pooled Michailins-Menter parameters and the effect of input rate of bioavailability. Clin. Pharmacol. Ther., 1985, 37: 481-487.
12. I. R. Martinez, M. C. G. A. Coque, R. M. V. Camanas. Liquid chromatographic procedure for the evaluation of β-blockers in pharmaceuticals using hybrid micellar mobile phases. J. Chromatogr. A, 1997, 765: 221-231.
13. Y. S. El-Saharty. Simultaneous high-performance liquid chromatographic assay of furosemide and propranolol HCl and its application in a pharmacokinetic study, J. Pharm. Biomed. Anal., 2003, 33: 699-709.
14. S. B. Black, A. M. Stenhouse, R. C. Hansson. Solid-phase extraction and derivatisation methods for β-blockers in human post mortem whole blood, urine and equine urine. J. Chromatogr. B, 1996, 685: 67-80.
15. P. Hubert, P. Chiap, M. Moors, et al. Knowledge-based system for the automated solid-phase extraction of basic drugs from plasma coupled with their liquid chromatographic determination: Application to the biodetermination of β-receptor blocking agents. J. Chromatogr. A, 1994, 665: 87-99.
16. F. F. T. Verves, H. G. Schaefer, J. T. Lefevre, et al. Simultaneous assay of propranolol, diltiazem and metabolites of diltiazem in human plasma by liquid chromatography. J. Pharm. Biomed. Anal., 1990, 8: 535-539.
17. Dalibor Satinsky, Hugo S. Serralheiro, Petr Solich, et al. On-line coupling of sequential injection extraction with restricted-access materials and post-column derivatization for sample clean-up and determination of propranolol in human plasma. Anal. Chim. Acta, 2007, 600: 122-128.
18. R.J. Ruane, I.D. Wilson. Ion-pair reversed-phase thin-layer chromatography of basic drugs using sulphonic acids. J. Chromatogr. A, 1988, 441 355-360.
19. I. Zelikman, S. Hjerten. Determination of total and free concentration of propranolol in human plasma by displacement electrophoresis in a two-layer polyacrylamide gel using fluorimetric detection. Biomed. Chromatogr., 1989, 3161-3165.
20. W. F. Smyth. Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography-electrospray ionisation mass spectrometry. J Chromatogr B. 2005, 824: 1-20.
21. Guidance for Industry, Bioanalytical Method Validation, US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), May 2001.