Synthesis and anticonvulsant activity of some novel isatin schiff's bases

International Journal of ChemTech Research

Volumn 1, Issue 3, 2009, Pages 758-763

  Sharma, Prince P ^a   Pandeya, S N ^a   Roy, R K ^a   Anurag, ^a   Verma, Krishan ^a   Gupta, S ^a  

^a Dr KNModi Institute of Pharmaceutical Education & Research Modinagar   (India)

Author keywords

Anticonvulsant activity; Isatin; Schiff's bases

Indexed keywords

3 (1,3 BENZOTHIAZOL 2 YLIMINO) 1, 3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 BROMO 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 CHLORO 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 ETHOXY 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 ETHYL 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 FLUORO 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 METHOXY 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 METHYL 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [(6 NITRO 1,3 BENZOTHIAZOL 2 YL)IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; 3 [[6 (DIMETHYLAMINO) 1,3 BENZOTHIAZOL 2 YL]IMINO] 1,3 DIHYDRO 2H INDOL 2 ONE; ANTICONVULSIVE AGENT; ISATIN; SCHIFF BASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; SEIZURE; TOXICITY TESTING;

EID: 77953406742     PISSN: None     EISSN: 09744290     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Gursoy A. and Karali N., 3-hydrazono-2-indolinones and mannich bases as potential anticonvulsants. Farmaco, 1996, 51, 437-442.
2. Verma M. Pandeya S.N. Singh K.N. and Stables J.P., Anticonvulsant activity of schiff bases of isatin derivatives. Acta Pharm. 2004, 54, 49-56.
3. Pandeya S.N. Sriram D. Clercq E.D.E. Pannecouque C. and Witvrouw M., Anti-HIV activity of some mannich bases of isatin derivatives. Indian Journal of Pharmaceutical Sciences, 1998, 60, 207-212
4. Kara L.V. Julie M.L. Marie R. Stephen G.P. and John B.B., An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins. Journal of Medicinal Chemistry, 2007, 50, 5109-5117.
5. Sriram D. Yogeeswari P. and Meena K., Synthesis, anti-HIV and antitubercular activities of isatin derivatives. Pharmazie, 2006, 61, 274-277.
6. Patel A. Baria S. Talele G. Patel J. and Sarangapani M., Synthesis and antimicrobial activity of some new isatin derivatives. Iranian Journal of Pharmaceutical Research, 2006, 4, 249-254.
7. Glover V. and Bhattacharya S.K., Isatin-A new Biological Factor. Ind. J. Exp. Biol. 199129, 1.
8. Pandeya S.N. Raja A.S. and Stables J.P., Synthesis of isatin semicarbazones as novel anticonvulsants-Role of hydrogen bonding. J. Pharm. Pharm. Sci. 2002, 5, 275-280.