Applying intelligent flow microscopy to biotechnology

BioProcess International

Volumn 7, Issue 6, 2009, Pages 62-67

  Sharma, Deepak K ^a   Oma, Peter ^a   King, David ^a  

^a Brightwell Technologies Inc   (Canada)

Author keywords

Analytical method development; Cell counting; Microflow imaging; Particle analysis

Indexed keywords

BIOTECHNOLOGY; CELL AGING; CHROMATOGRAPHY; FERMENTATION; HISTOGRAM; MICROSCOPY; PARTICLE SIZE; PROTEIN AGGREGATION; SENSITIVITY ANALYSIS; SHORT SURVEY;

EID: 77953395330     PISSN: 15426319     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Short Survey

References (8)

1. Huang CT, et al. Quantitation of Protein Particles in Parenteral Solutions Using Micro-Flow Imaging. J. Pharm. Sci. 10, 2008: 1002/jps.21575.
2. Sharma DK, et al. Flow Microscopy for Particulate Analysis in Parenteral and Pharmaceutical Fluids. Eur. J. Pharm. Sci. 12, 2007: 97-101.
3. Carpenter JF, et al. Overlooking Subvisible Particles in Therapeutic Protein Products: Gaps That May Compromise Product Quality. J. Pharm. Sci. 10, 2008: 1002/jps.21530.
4. Moore P. Case Studies Using Flow Microscopy for Contaminant Analysis. PDA Visual Inspection Forum, Berlin, Germany, 14-17 October 2008.
5. Beckman-Coulter, Vi-CELL (www.beckmancoulter.com); innovatis AG, Cedex (www.innovatis.com).
6. Graf H, Rabaud JN, Egly JM. Screening of Various Mammalian Cell Culture Media to Establish a Downstream Purification Scheme. J. Immunol. Meth. 139, 1991: 135-144.
7. Pläsier B, et al. Automatic Image Analysis for Quantification of Apoptosis in Animal Cell Culture By Annexin-V Affinity Assay. J. Immunol. Meth. 229, 1999: 81-95.
8. Pons MN, et al. Application of Quantitative Image Analysis to a Mammalian Cell Line Grown on Micro-Carriers. Biotechnol. Bioeng. 40, 1992: 187-193.