Predicting 6-week mortality after acute variceal bleeding: Role of classification and regression tree analysis

Annals of Hepatology

Volumn 8, Issue 4, 2009, Pages 308-315

  Altamirano, Jose ^a,b   Zapata, Laura ^b   Augustin, Salvador ^c   Muntaner, Laura ^a   Gonzalez Angulo, Alberto ^a   Ortiz, Ana Laura ^b   Degiau, Louis ^b   Garibay, Juan ^e   Camargo, Leonardo ^e   Genesca, Joan ^d  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b Gastroenterology Unit   (Spain)

^c HOSPITAL JUÁREZ DE MÉXICO   (Mexico)

^d HOSPITAL GENERAL DE MÉXICO   (Mexico)

^e UNIVERSIDAD LA SALLE   (Mexico)

Author keywords

Child pugh; Cirrhosis; Classification and regression tree (CART) analysis; MELD; Portal hypertension; Prognostic scores; Variceal bleeding

Indexed keywords

ALBUMIN; BILIRUBIN; VASOACTIVE AGENT; SERUM ALBUMIN;

ABSENCE OF SIDE EFFECTS; ACCURACY; ADULT; ALBUMIN BLOOD LEVEL; ALGORITHM; AREA UNDER THE CURVE; ARTICLE; BILIRUBIN BLOOD LEVEL; CHILD PUGH SCORING SYSTEM; CLASSIFICATION AND REGRESSION TREE ANALYSIS; CLINICAL ASSESSMENT; CONTROLLED STUDY; ESOPHAGUS VARICES; ESOPHAGUS VARICES BLEEDING; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MELD SCORING SYSTEM; MORTALITY; PREDICTION; PREDICTIVE VALUE; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; RECURRENT DISEASE; SCORING SYSTEM; BLEEDING; BLOOD; EVALUATION; KAPLAN MEIER METHOD; LIVER CIRRHOSIS; METABOLISM; MIDDLE AGED; RETROSPECTIVE STUDY; STATISTICAL MODEL; TIME;

ADULT; ALGORITHMS; BILIRUBIN; ESOPHAGEAL AND GASTRIC VARICES; FEMALE; HEMORRHAGE; HUMANS; KAPLAN-MEIERS ESTIMATE; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MODELS, STATISTICAL; PROGNOSIS; RETROSPECTIVE STUDIES; ROC CURVE; SERUM ALBUMIN; TIME FACTORS;

EID: 77953378433     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31743-0     Document Type: Article

References (26)

1. Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology 1981; 80: 800-899.
2. Gines P, Quintero E, Arroyo V. Compensated cirrhosis: natural history and prognosis. Hepatology 1987; 7: 122-128.
3. D'Amico G, Luca A. Natural history. Clinical-hemodynamic correlations. Prediction of the risk of rebleeding. Baillie-res Clin Gastroenterol 1997; 11: 243-246.
4. El-Serag HB, Everhart JE. Improved survival after variceal hemorrhage over an 11-year old period in the Department of Veterans Affairs. Am J Gastroenterol 2000; 95: 3566-3573.
5. McCormick PA, O'Keefe C. Improving prognosis following a first variceal hemorrhage over four decades. Gut 2001; 49: 682-5.
6. Chalasani N, Kahi C, Francois F, et al. Improved patient survival after acute variceal bleeding: a multicenter, cohort study. Am J Gastroenterol 2003; 98: 653-659.
7. Carbonell N, Pauwels A, Serfaty L, et al. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology 2004; 40: 652-659.
8. D'Amico G, De Franchis R. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology 2003; 38: 599-612.
9. Thomopoulos K, Theocharis G, Mimidis K, et al. Improved survival of patients presenting with acute variceal bleeding: Prognostic indicators of short- and long-term mortality. Dig Liv Dis 2006; 38: 899-904.
10. Bambha K, Kim WR, Pedersen R, et al. Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis. Gut 2008; 57: 814-820.
11. D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies. J Hepatol 2006; 44: 217-231.
12. Amitrano L, Guardascione MA, Bennato R, et al. MELD score and hepatocellular carcinoma identify patients at different risk of short-term mortality among cirrhotics bleeding from esophageal varices. J Hepatol 2005; 42: 820-825.
13. Lee JY, Lee JH, Kim SJ, et al. Comparison of predictive factors related to the mortality and rebleeding caused by variceal bleeding: Child Pugh score, MELD score and Roc-kall score. Taehan kan Hakhoe Chi 2002; 8: 458-464.
14. CART analysis for acute variceal bleeding. Annals of tlepdtolOiJV. 2009; 8 (4): 308-315 QIS
15. Chalasani N, Kahi C, Francois F, et al. Model for End-Stage Liver Disease (MELD) for predicting mortality in patients with acute variceal bleeding. Hepatology 2002; 35: 1282-1284.
16. Flores-Rendon AR, Gonzalez-Gonzalez JA, Garcia-Compean D, et al. Model for end stage of liver disease (MELD) is better than the Child-Pugh score for predicting inhospital mortality related to esophageal variceal bleeding. Ann Hepatol 2008 Jul-Sep; 7: 230-234.
17. Keller F, Heinze H, Jochimsen F, et al. Risk factors and outcome of 107 patients with decompensated liver disease and acute renal failure (including 26 patients with hepatorenal syndrome): the role of hemodialysis. Ren Fail 1995; 17: 135-146.
18. Hess KR, Abbruzzese MC, Lenzi R, et al. Classification and regression tree analysis of 1000 consecutive patients with unknown primary carcinoma. Clin Cancer Res 1999; 5: 3403-3410.
19. Horowitz N, Moshkowitz M, Halpern Z, et al. Applying data mining techniques in the development of a diagnostics questionnaire for GERD. Dig Dis Sci 2007; 52: 1871-188.
20. Austin PC. A comparison of regression trees, logistic regression, generalized additive models, and multivariate adaptive regression splines for predicting AMI mortality. Stat Med 2007; 15: 2937-57.
21. Muller R, Mockel M. Logistic regression and CART in the analysis of multimarker studies. Clin Chim Acta 2008; 394: 1-6.
22. Augustin S, Muntaner L, Altamirano J, et al. Prognostic assessment of early mortality after acute variceal hemorrhage based on classification and regression tree analysis. EASLD monothematic conference, Portal hypertension: advances in knowledge, evaluation and management. Abstract 32; p. 31.
23. Hernandez-Gea V, Colomo A, Aracil C, et al. Influence of early rebleeding on thelong term outcome of patients treated to prevent recurrent variceal haemorrage. EASLD monothematic conference, Portal hypertension: advances in knowledge, evaluation and management. Abstract 27; p. 25.
24. De Franchis R, Pascal JP, Ancona E, et al. Definitions, methodology and therapeutic strategies in portal hypertension. J HepatoM 992; 15:256-261.
25. Cardenas A, Gines P, Uriz J, et al. Renal Failure After Upper Gastrointestinal Bleeding in Cirrhosis: Incidence, Clinical Course, Predictive Factors, and Short-Term Prognosis. Hepatology 2001; 34: 671-6.
26. Garcia-Tsao G, Sanyal AJ, Grace ND, et al. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46: 922-938.