Effect of tablet excipients on mucoadhesive properties of polyoxyethylene and Carbopol 971P

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn , Issue 1, 2009, Pages 198-205

  Derle, Deelip ^a   Joshi, Omkar ^a   Pawar, Ashish ^a   Patel, Jatin ^a   Perdeshi, Vaishali ^a  

^a Department of Pharmacology   (India)

Author keywords

Excipient; Gastric mucoadhesion; Mucoadhesion; Percent hydration

Indexed keywords

ACICLOVIR; BETA CYCLODEXTRIN; CALCIUM CHLORIDE; CARBOPOL 971P; CETRIMIDE; CROSPOVIDONE; CYCLODEXTRIN; DODECYL SULFATE SODIUM; EDETIC ACID; EXCIPIENT; LACTOSE; MANNITOL; METRONIDAZOLE; MICROCRYSTALLINE CELLULOSE; OFLOXACIN; POLYMER; POLYOXYETHYLENE; POLYSORBATE 80; POVIDONE; STARCH; STARCH GLYCOLATE SODIUM; SURFACTANT; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ARTICLE; CHELATION; DILUTION; GOAT; HYDRATION; MUCOADHESION; STOMACH MUCOSA; SWELLING; TABLET FORMULATION;

EID: 77953376317     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Tobyn MJ, Johnson JR, Dettmar PW. Factors affecting in vitro gastric mucoadhesion I. Instrumental parameters and experimental conditions. Eur J Pharm Biopharm 1995;41(4):235-41.
2. Tobyn MJ, Johnson JR, Dettmar PW. Factors affecting in vitro gastric mucoadhesion II. Physical properties of polymers. Eur. J. Pharm. Biopharm 1996;42(1):56-61.
3. Perez-Marcos B. lglesias R. Gomezamosa JL. Marinez-Pachecho, R, Souto C, Concheiro A. Usefulness of certain varieties of Carbomer in the formulation of hydrophilic furosemide matrices. Int J Pharm 1991;67:113-21.
4. Perez-Marcos B, Iglesias R, Gomezamosa JL, Marinez-Pachecho R. Souto C, Concheiro A. Mechanical and drug-release properties of atenolol-Carbomer hydrophillic matrix tablets. J Control Release 1991:17:267-76.
5. Harris D. Fell JT, Sharma HL, Taylor DC. GI transit of potential bioadbesive systems in the rat. J Control Release 1990; 12:55-65.
6. Tobyn MJ, Johnson JR, Dettmar PW. Factors affecting in vitro gastric mucoadhesion 111 influence of polymer addition on the observed mucoadhesion of some materials. Eur J Pharm Biopharm 1996:42:331-335.
7. Tobyn MJ. Factors affecting in vitro gastric mucoadhesion, Ph.D. thesis. University of Strathclyde, 1994.
8. Ponchel G, Touchard F. Duchene D, Peppas NA. Bioadhesive analysis of controlled release systems. 1. Fracture and interpenetration analysis in poly (acrylic acid)-containing systems. J Control Release 1987; 5:129-41,
9. Hochberg Y. Tamhane AC. Multiple comparison procedures, New York: Wiley. 1987:66.
10. Hafeez Hussain MS, York P. Timmins P. A study of the formation of magnesium stearate film on sodium chloride using energy dispersive X-ray analysis. Int J Pharm 1988;42:89-95.
11. Johansson ME. Investigations of the mixing time dependence of the lubricating properties of granular and powdered magnesium stearate. Acta Pharm Suet 1985; 22:343-50.
12. Mortazavi SA, Smart JD. An investigation into the role of water movement and mucus gel hydration in mucoadhesion. J Control Release 1993; 25:197-203.
13. Chen W-G, Hwang C-CH. Adhesive and in vitro release characteristics of a propranolol bioadhesive disc system. Int J Pharm 1992; 82:61-6.
14. Handbook of pharmaceutical excipients, 2nd edition. A. Wade and P.J. Weller (Eds). Pharmaceutical Press (London) 1994.
15. Jones SP, Grant DJW, Hadgraft J, Parr GD. Cyclodextrins in the pharmaceutical sciences. Part I: preparation. structure and properties of cyclodextrins and cyclodextrin inclusion compounds. Acta Pharm Technol 1984; 30(3):213-33.
16. Baszkin A. Proust JA, Monsengo P, Boissonade MM. Wettability of polymers by mucin aqueous solutions. Biorheology 1990; 27:503-14.
17. Lehr C-M, Bouwstra JA, Bodde HE, Junginger HE. A surface energy analysis of mucoadhesion: contact angle measurements on polycarbophil and pig intestinal mucosa in physiologically relevant fluids. Pharm Res 1992; 9(1):70-5.
18. Bodde HE, Bouwstrd JA, Junginger HE. Bioadhesive polymerssurface energy and molecular energy mobility considerations. Biofouling 1991; 4:163-9.
19. Vries ME, Boddi HE, Busscher HJ, Junginger HE. Hydrogels for buccdl drug delivery: properties relevant for mucoadhesion. J Biomed Mater Res 1988; 22:1023-32.
20. Mikos AC, Peppas NA. Measurement of the surface tension of mucin solutions. Int J Pharm 1989; 53:1-5.
21. Rillosi M. Buckton G. Modelling mucoadhesion by use of surface energy terms obtained by the Lewis acid-Lewis base relationship. Int J Pharm 1995; 117(1):75-84.
22. Rillosi M. Buckton G. Modelling mucoadhesion by use of surface energy terms obtained from the Lewis acid-Lewis base approach. Il. Studies on anionic, cationic and unionisable polymers. Pharm Res 1995; 12(5):669-75.
23. Esposito P, Colombo I, Lovrecich M. Investigation of surface properties of some polymers by a thermodynamic and mechanical approach: possibility of predicting mucoadhesion. Biomaterials 1994; 15(3):177-82.
24. Spychal RT. Marrero JM, Saverymutto SH, Northtield TC. Measurement of surface hydrophobicity of human gastrointestinal mucosa. Gastroenterology 1989; 97: l04-11.
25. Pritchard WH. The role of hydrogen bonding in adhesion. In: D. Alder, editor. Aspects of adhesion. London: London University Press, 1970; 6:11-23.
26. Leung S-HS. Robinson JR. Polymer structural features contributing to mucoadhesion II. J Control Release 1990; 12:187-94.
27. Lejoyeux F, Ponchel G, Woussidjewe D, Peppas NA, Duchene D. Bioadhesive tablets: influence of testing medium composition on bioadhesion. Drug Dev Ind Pharm 1992; 15 (12):2037-48.