Effect of an endurance-like exercise on the disposition and detection time of phenylbutazone and dexamethasone in the horse: Application to medication control

Equine Veterinary Journal

Volumn 42, Issue 3, 2010, Pages 240-247

  Authie, E C ^a   Garcia, P ^a,c   Popot, M A ^a,c   Toutain, P L ^a   Doucet, M ^a,b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c LCH   (France)

Author keywords

Detection time; Dexamethasone; Doping; Exercise; Horse; Phenylbutazone

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; PHENYLBUTAZONE;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; BLOOD; BLOOD SAMPLING; FEMALE; HALF LIFE TIME; HORSE; MALE; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL AVAILABILITY; BLOOD SPECIMEN COLLECTION; DEXAMETHASONE; FEMALE; HALF-LIFE; HORSES; MALE; PHENYLBUTAZONE; PHYSICAL CONDITIONING, ANIMAL;

EID: 77953367679     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00029.x     Document Type: Article

References (18)

1. Barragry, T. (2006) Continuing education - Doping and drug detection times in horses: new data for therapeutic agents. Irish vet. J. 59, 394-398.
2. Cunningham, F.E., Rogers, S., Fischer, J.H. and Jensen, R.C. (1996) The pharmacokinetics of dexamethasone in the thoroughbred racehorse. J. vet. Pharmacol. Ther. 19, 68-71.
3. Dyke, T.M., Hinchcliff, K.W., Sams, R.A., McKeever, K.H. and Muir, W.W. (1996) The effects of submaximal exercise on the pharmacokinetics of furosemide in horses. J. vet. Pharmacol. Ther. 19, 164-166.
4. Dyke, T.M., Hubbell, J.A., Sams, R.A. and Hinchcliff, K.W. (1998a) Hepatic blood flow in horses during the recuperative period from maximal exercise. Am. J. vet. Res. 59, 1476-1480.
5. Dyke, T.M., Sams, R.A. and Hinchcliff, K.W. (1998b) Intensity-dependent effects of acute submaximal exercise on the pharmacokinetics of bromsulphalein in horses. Am. J. Vet. Res. 59, 1481-1487.
6. Gibaldi, M. and Perrier, D. (1982) Pharmacokinetics, 2nd edn., Marcel Dekker, New York.
7. Gleadhill, A., Marlin, D., Harris, P.A. and Michell, A.R. (2000) Reduction of renal function in exercising horses. Equine vet. J. 32, 509-514.
8. Graham-Thiers, P.M., Kronfeld, D.S., Kline, K.A., Sklan, D.J. and Harris, P.A. (2003) Dietary protein and fat effects on protein status in Arabian horses during interval taining and repeated sprints. J. equine vet. Sci. 23, 554-559.
9. McKeever, K.H., Hinchcliff, K.W., Reed, S.M. and Robertson, J.T. (1993) Role of decreased plasma volume in hematocrit alterations during incremental treadmill exercise in horses. Am. J. Physiol. 265, R404-R408.
10. Manohar, M., Goetz, T.E., Saupe, B., Hutchens, E. and Coney, E. (1995) Thyroid, renal, and splanchnic circulation in horses at rest and during short-term exercise. Am. J. vet. Res. 56, 1356-1361.
11. Poortmans, J.R. (1977) Exercise and renal function. Exerc. Sports Sci. Rev. 5, 255-294.
12. Rowland, M. and Tozer, T.N. (1995) Clinical Pharmacokinetics. Concepts and Applications, 3rd edn., Williams and Wilkins, London.
13. Smith, R.L. (2000) The zero tolerance approach to doping control in horseracing: a fading illusion? In: 13th International Conference of Racing Analysts and Veterinarians, Eds: R.B. Williams, E. Houghton and J.F. Wade, R & W, Cambridge. pp 9-14.
14. Soma, L.R., Gallis, D.E., Davis, W.L., Cochran, T.A. and Woodward, C.B. (1983) Phenylbutazone kinetics and metabolite concentrations in the horse after five days of administration. Am. J. vet. Res. 44, 2104-2109.
15. Somani, S.M., Gupta, K., Frank, S. and Corder, C.N. (1990) Effect of exercise on disposition and pharmacokinetics of drugs. Drug Dev. Res. 20, 251-275.
16. Toutain, P.L. (2010) How to extrapolate a withdrawal time from an EHSLC published detection time: a Monte Carlo simulation appraisal. Equine vet. J. 42, 248-254.
17. Toutain, P.L. and Bousquet-Melou, A. (2004) Plasma terminal half-life. J. Vet. Pharmacol. Ther. 27, 427-439.
18. Ylitalo, P. (1991) Effect of exercise on pharmacokinetics. Ann. Med. 23, 289-294.