Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves

Journal of Ethnopharmacology

Volumn 129, Issue 3, 2010, Pages 391-397

  Mendes, S S ^a   Bomfim, R R ^a   Jesus, H C R ^a   Alves, P B ^a   Blank, A F ^a   Estevam, C S ^a   Antoniolli, A R ^a   Thomazzi, S M ^a  

^a FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

Anti inflammatory activity; Antinociceptive activity; Essential oil; Lippia gracilis

Indexed keywords

ACETIC ACID; ACETYLSALICYLIC ACID; BUTYLCRESOL; DEXAMETHASONE; ESSENTIAL OIL; GALLIC ACID; HERBACEOUS AGENT; LIPPIA GRACILIS EXTRACT; PARA CYMENE; THYMOL; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAZIL; CONTROLLED STUDY; DRUG DETERMINATION; FEMALE; IC 50; LEUKOCYTE MIGRATION; LIPPIA GRACILIS; MALE; MOUSE; NONHUMAN; PAW EDEMA; PERITONITIS; PLANT LEAF; RAT; VERBENACEAE; WRITHING TEST;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CHEMOTAXIS, LEUKOCYTE; EDEMA; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LEUKOCYTE COUNT; LIPPIA; MALE; MICE; OILS, VOLATILE; PAIN; PERITONEAL CAVITY; PERITONITIS; PLANT LEAVES; PLANT OILS; RATS; RATS, WISTAR;

LIPPIA; VERBENACEAE;

EID: 77953364364     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.04.005     Document Type: Article

References (36)

1. Adams R.P. Identification of Essential Oil Components by Gas Chromatograpy/Quadrupopole Mass Spectroscopy 2007, Allured Publishing Corporation, Carol Stream, IL, USA, p. 804.
2. Agra M.F., Freitas P.F., Barbosa-Filho J.M. Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Revista Brasileira de Farmacognosia 2007, 17:114-140.
3. Albuquerque U.P., Medeiros P.M., Almeida A.L.S., Monteiro J.M., Lins Neto E.M.F., Melo J.G., Santos J.P. Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach. Journal of Ethnopharmacology 2007, 114:325-354.
4. Bakkali F., Averbeck S., Averbeck D., Idaomar M. Biological effects of essential oils - a review. Food and Chemical Toxicology 2008, 46:446-475.
5. Bezerra P., Fernandes A.G., Craveiro A.A., Andrade C.H.S., Matos F.J.A., Alencar J.W., Machado M.I.L., Viana G.S.B., Matos F.F., Rouquayrol Mz. Composição química e atividade biológica de óleos essenciais de plantas do Nordeste-gênero Lippia. Ciência e Cultura 1981, 33:1-14.
6. Braga P.C., Dal Sasso M., Culici M., Bianchi T., Bordoni L., Marabini L. Anti-inflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase. Pharmacology 2006, 77:130-136.
7. Brand-Williams W., Cuvelier M.E., Berset C. Use of a free radical method to evaluate antioxidant activity. Lebensmittel Wissenschaft Technologie 1995, 28:25-30.
8. Chanotiya C.S., Yadav A. Enantiomeric composition of (3R)-(-)- and (3S)-(+)-linalool in various essential oils of Indian origin by enantioselective capillary gas chromatography-flame ionization and mass spectrometry detection methods. Natural Products Communications 2009, 4:563-566.
9. Collier H.O., Kinneen L.C., Johnson C.A., Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. British Journal of Pharmacology 1968, 32:295-310.
10. Duarte I.D., Nakamura M., Ferreira S.H. Participation of the sympathetic system in acetic acid-induced writhing in mice. Brazilian Journal of Medical and Biological Research 1988, 21:341-343.
11. Fricke C., Hardt I.H., König W.A., Joulain D., Zygadlo J.A., Guzmàn C.A. Sesquiterpenes from Lippia integrifolia essential oil. Journal of Natural Products 1999, 62:694-696.
12. Haeseler G., Maue D., Grosskreutz J., Bufler J., Nentwig B., Piepenbrock S., Dengler R., Leuwer M. Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. European Journal of Anaesthesiology 2002, 19:571-579.
13. Hotta M., Nakata R., Katsukawa M., Hori K., Takahashi S., Inoue H. Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression. Journal of Lipid Research 2010, 51:132-139.
14. Jansen-Jacobs M.J. Verbenaceae. Flora of the Guianas, Series A: Phanerogams, Fascicle 4 (148) 1988, Gorts-Van Hoetz Scientific Books, Koenigstein, p. 116. A.R.A. Rijn (Ed.).
15. Juergens U.R., Stober M., Vetter H. Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1,8-cineole) in human blood monocytes in vitro. European Journal of Medical Research 1998, 17:508-510.
16. Koster R., Anderson N., Debber E.J. Acetic acid for analgesic screening. Federation Proceedings 1959, 18:418-420.
17. Li D.W., Lee E.B., Kang S.S., Hyun J.E., Whang W.K. Activity guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity. Chemical Pharmaceutical Bulletin 2002, 50:900-903.
18. Loram L.C., Fuller A., Fick L.G., Cartmell T., Poole S., Mitchell D. Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw. The Journal of Pain 2007, 8:127-136.
19. Lorenzi H., Matos F.J.A. Plantas Medicinais no Brasil: Nativas e Exóticas 2008, Instituto Plantarum, Nova Odessa. second ed.
20. Marreto R.N., Almeida E.E.C.V., Alves P.B., Niculau E.S., Nunes R.S., Matos C.R.S., Araújo A.A.S. Thermal analysis and gas chromatography coupled mass spectrometry analyses of hydroxypropyl-β-cyclodextrin inclusion complex containing Lippia gracilis essential oil. Thermochimica Acta 2008, 475:53-58.
21. 2 biosyntheses. Planta Medica 2005, 71:739-742.
22. Martínez M.J., Betancourt J., Alonso-González N., Jauregui A. Screening of some Cuban medicinal plants for antimicrobial activity. Journal of Ethnopharmacology 1996, 52:171-174.
23. Matos F.J.A., Machado M.I.L., Craveiro A.A., Alencar J.W., Silva M.G.V. Medicinal plants Northeast Brazil containing thymol and carvacrol-Lippia sidoides Cham. and L. gracilis H.B.K (Verbenaceae). Journal of Essential Oil Research, Wheaton 1999, 11:666-668.
24. Matos L.G., Santos L.D.A.R., Vilela C.F., Pontes I.S., Tresvenzol L.M.F., Paula J.R., Costa E.A. Atividades analgésica e/ou antiinflamatória da fração aquosa do extrato etanólico das folhas da Spiranthera odoratissima A. St. Hillaire (manacá). Revista Brasileira de Farmacognosia 2003, 13:15-16.
25. Moldenke H.N. Materials toward a monograph of the genus Lippia. I. Phytologia 1965, 12:331-334.
26. Pascual M.E., Slowing K., Carretero E., Sánchez Mata D., Villar A. Lippia: traditional uses, chemistry and pharmacology: a review. Journal of Ethnopharmacology 2001, 76:201-214.
27. Salvemini D., Wang Z.Q., Wyatt P.S., Bourdon D.M., Marino M.H., Manning P.T., Currie M.G. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. British Journal of Pharmacology 1996, 118:829-838.
28. Santos A.R.S., Vedana E.M.A., Freitas G.A.G. Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. Inflammation Research 1998, 47:302-307.
29. Santos F.A., Rao V.S.N. Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytotherapy Research 2000, 14:240-244.
30. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W., Lee L., Isakson P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:12013-12017.
31. Siani A.C., Tappin M.R., Ramos M.F., Mazzei J.L., Ramos M.C., De Aquino Neto F.R., Frighetto N. Linalool from Lippia alba: study of the reproducibility of the essential oil profile and the enantiomeric purity. Journal of Agricultural and Food Chemistry 2002, 50:3518-3521.
32. Silva W.J., Dória G.A.A., Maia R.T., Nunes R.S., Carvalho G.A., Blank A.F., Alves P.B., Marçal R.M., Cavalcanti S.C.H. Effects of essential oils on Aedes aegypti larvae: alternatives to environmentally safe insecticides. Bioresource Technology 2008, 99:3251-3255.
33. Souza M.C., Siani A.C., Ramos M.F., Menezes-de-Lima O.J., Henriques M.G. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. Pharmazie 2003, 58:582-586.
34. Stashenko E.E., Jaramillo B.E., Martínez J.R. Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) N.E. Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity. Journal of Chromatography A 2004, 1025:93-103.
35. Van Den Dool H., Kratz D.J. A generalization of the retention index system including liner temperature programmed gas-liquid partition chromatography. Journal of Chromatography 1963, 11:463-467.
36. Winter C.A., Risley E.A., Nuss G.W. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 1962, 111:544-547.