The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

Biochemical Pharmacology

Volumn 80, Issue 3, 2010, Pages 381-388

  Hewawasam, Ruwani ^a   Liu, Dan ^a   Casarotto, Marco G ^a   Dulhunty, Angela F ^a   Board, Philip G ^a  

^a Biology and Environment   (Australia)

Author keywords

Calcium release from cardiac sarcoplasmic reticulum; Calcium release from skeletal sarcoplasmic reticulum; Cardiac RyR2 channels; Glutathione transferase GSTM2 2; Lipid bilayer single channel experiments; Skeletal RyR1 channels

Indexed keywords

ALANINE; ASPARTIC ACID; CALCIUM ION; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE M2 2; LEUCINE; PHENYLALANINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CELL VACUOLE; CONTROLLED STUDY; CYTOSOL; DIASTOLE; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; HEART ARRHYTHMIA; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; RECEPTOR BLOCKING;

ANIMALS; CALCIUM CHANNEL BLOCKERS; GLUTATHIONE TRANSFERASE; HUMANS; MYOCYTES, CARDIAC; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SHEEP;

EID: 77953356388     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.04.019     Document Type: Article

References (20)

1. Abdellatif Y., Liu D., Gallant E.M., Gage P.W., Board P.G., Dulhunty A.F. The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels. Cell Calcium 2007, 41:429-440.
2. Wei L., Abdellatif Y.A., Liu D., Kimura T., Coggan M., Gallant E.M., et al. Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity. Int J Biochem Cell Biol 2008, 40:1616-1628.
3. Laver D.R., Baynes T.M., Dulhunty A.F. Magnesium inhibition of ryanodine-receptor calcium channels: evidence for two independent mechanisms. J Membr Biol 1997, 156:213-229.
4. 2+] on excitation-contraction coupling in skeletal muscle fibres of the rat. J Physiol 1994, 478(Pt 2):331-339.
5. Dulhunty A.F., Beard N.A., Pouliquin P., Casarotto M.G. Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?. Pharmacol Ther 2007, 113:247-263.
6. Liu D., Hewawasam R., Pace S.M., Gallant E.M., Casarotto M.G., Dulhunty A.F., et al. Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2. Biochem Pharmacol 2009, 77:1181-1193.
7. Aceto A., Dragani B., Melino S., Allocati N., Masulli M., Di Ilio C., et al. Identification of an N-capping box that affects the alpha 6-helix propensity in glutathione S-transferase superfamily proteins: a role for an invariant aspartic residue. Biochem J 1997, 322(Pt 1):229-234.
8. Baker R.T., Catanzariti A.M., Karunasekara Y., Soboleva T.A., Sharwood R., Whitney S., et al. Using deubiquitylating enzymes as research tools. Methods Enzymol 2005, 398:540-554.
9. Chamberlain B.K., Fleischer S. Isolation of canine cardiac sarcoplasmic reticulum. Methods Enzymol 1988, 157:91-99.
10. 2+ inhibits the ryanodine receptor from cardiac muscle. J Membr Biol 1995, 147:7-22.
11. Ahern G.P., Junankar P.R., Dulhunty A.F. Single channel activity of the ryanodine receptor calcium release channel is modulated by FK-506. FEBS Lett 1994, 352:369-374.
12. Dulhunty A., Gage P., Curtis S., Chelvanayagam G., Board P. The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. J Biol Chem 2001, 276:3319-3323.
13. 2+ release channels. Int J Biochem Cell Biol 2004, 36:1599-1612.
14. 2+ and ATP. Biochem J 2005, 390:333-343.
15. Jalilian C., Gallant E.M., Board P.G., Dulhunty A.F. Redox potential and the response of cardiac ryanodine receptors to CLIC-2, a member of the glutathione S-transferase structural family. Antioxid Redox Signal 2008, 10:1675-1686.
16. Raghunathan S., Chandross R.J., Kretsinger R.H., Allison T.J., Penington C.J., Rule G.S. Crystal structure of human class mu glutathione transferase GSTM2-2. Effects of lattice packing on conformational heterogeneity. J Mol Biol 1994, 238:815-832.
17. Kermode H., Williams A.J., Sitsapesan R. The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor. Biophys J 1998, 74:1296-1304.
18. 2+ gating of skeletal muscle and cardiac ryanodine receptors. Biophys J 1997, 73:141-156.
19. Wei L., Gallant E.M., Dulhunty A.F., Beard N.A. Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin. Int J Biochem Cell Biol 2009, 41:2214-2224.
20. Trafford A.W., Diaz M.E., Eisner D.A. Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca. Cardiovasc Res 1998, 37:710-717.