Uterine leiomyosarcoma arising in leiomyoma: Clinicopathological study of four cases and literature review: Original Article

Pathology International

Volumn 60, Issue 7, 2010, Pages 506-509

  Yanai, Hiroyuki ^a   Wani, Yoji ^b   Notohara, Kenji ^b   Takada, Shin Ichi ^c   Yoshino, Tadashi ^d  

^a OKAYAMA UNIVERSITY HOSPITAL   (Japan)

^b KURASHIKI CENTRAL HOSPITAL   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d HIROSHIMA CITY HOSPITAL   (Japan)

Author keywords

Ki 67; Leiomyoma; Leiomyosarcoma; P16; P53

Indexed keywords

KI 67 ANTIGEN; PROTEIN P16; PROTEIN P53; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ADULT; ARTICLE; CANCER STAGING; CASE REPORT; CELL COUNT; CELL DEATH; CELL TRANSFORMATION; CYTOLOGY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HYSTERECTOMY; IMMUNOHISTOCHEMISTRY; LEIOMYOSARCOMA; MITOSIS; PRIORITY JOURNAL; TUMOR CELL; TUMOR LOCALIZATION; TUMOR VOLUME; UTERUS CANCER; UTERUS LEIOMYOSARCOMA; UTERUS MYOMA; BIOSYNTHESIS; LEIOMYOMA; METABOLISM; MIDDLE AGED; MULTIPLE CANCER; PATHOLOGY;

ADULT; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LEIOMYOMA; LEIOMYOSARCOMA; MIDDLE AGED; NEOPLASMS, MULTIPLE PRIMARY; TUMOR SUPPRESSOR PROTEIN P53; UTERINE NEOPLASMS;

EID: 77953328963     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2010.02549.x     Document Type: Article

References (31)

1. Zaloudek C, Hendrickson MR. Mesenchymal tumors of the uterus. In : Kurman RJ, ed. Blaustein's Pathology of Female Genital Tract, 5th edn.
2. Lowell DM, Karsh J. Leiomyosarcoma of the broad ligament. A case report. Obstet Gynecol 1968 32 : 107 110.
3. Hart WR, Billman JK Jr. A reassessment of uterine neoplasms originally diagnosed as leiomyosarcomas. Cancer 1978 41 : 1902 1910.
4. Herbold DR, Fu YS, Silbert SW. Leiomyosarcoma of the broad ligament. A case report and literature review with follow-up. Am J Surg Pathol 1983 7 : 285 292.
5. Scurry J, Hack M. Leiomyosarcoma arising in a lipoleiomyoma. Gynecol Oncol 1990 39 : 381 383.
6. Mittal K, Popiolek D, Demopoulos RI. Uterine myxoid leiomyosarcoma within a leiomyoma. Hum Pathol 2000 31 : 398 400.
7. Kir G, Eren S, Akoz I, Kir M. Leiomyosarcoma of the broad ligament arising in a pre-existing pure neurilemmoma-like leiomyoma. Eur J Gynaecol Oncol 2003 24 : 505 506.
8. Mittal K, Joutovsky A. Areas with benign morphologic and immunohistochemical features are associated with some uterine leiomyosarcomas. Gynecol Oncol 2007 104 : 362 365.
9. Mittal KR, Chen F, Wei JJ et al. Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. Mod Pathol 2009 22 : 1303 1311.
10. Hendrickson MR, Tavassoli FA, Kempson RL, McCluggage WG, Haller U, Kubik-Huch RA. Mesenchymal tumours and related lesions. In : Tavassoli FA, Devilee P, eds. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Breast and Female Genital Organs.
11. Chen L, Yang B. Immunohistochemical analysis of p16, p53, and Ki-67 expression in uterine smooth muscle tumors. Int J Gynecol Pathol 2008 27 : 326 332.
12. Taylor HB, Norris HJ. Mesenchyma tumors of the uterus. IV. Diagnosis and prognosis of leiomyosarcomas. Arch Pathol 1966 82 : 40 44.
13. Mayerhofer K, Obermair A, Windbichler G et al. Leiomyosarcoma of the uterus: A clinicopathologic multicenter study of 71 cases. Gynecol Oncol 1999 74 : 196 201.
14. Przybora LA. Leiomyosarcoma in situ of the uterus. Cancer 1961 14 : 483 492.
15. Montague AC, Swartz DP, Woodruff JD. Sarcoma arising in a leiomyoma of the uterus: Factors influencing prognosis. Am J Obstet Gynecol 1965 92 : 421 427.
16. Spiro RH, Koss LG. Myosarocma of the uterus; a clinicopathological study. Cancer 1965 18 : 571 588.
17. Silverberg SG. Leiomyosarcoma of the uterus. A clinicopathologic study. Obstet Gynecol 1971 38 : 613 628.
18. Bodner-Adler B, Bodner K, Czerwenka K, Kimberger O, Leodolter S, Mayerhofer K. Expression of p16 protein in patients with uterine smooth muscle tumors: An immunohistochemical analysis. Gynecol Oncol 2005 96 : 62 6.
19. O'Neill CJ, McBride HA, Connolly LE, McCluggage WG. Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology 2007 50 : 851 858.
20. Atkins KA, Arronte N, Darus CJ, Rice LW. The use of p16 in enhancing the histologic classification of uterine smooth muscle tumors. Am J Surg Pathol 2008 32 : 98 102.
21. Gannon BR, Manduch M, Childs TJ. Differential immunoreactivity of p16 in leiomyosarcomas and leiomyoma variants. Int J Gynecol Pathol 2008 27 : 68 73.
22. Ip PP, Cheung AN, Clement PB. Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP): A clinicopathologic analysis of 16 cases. Am J Surg Pathol 2009 33 : 992 1005.
23. Jeffers MD, Farquharson MA, Richmond JA, McNicol AM. p53 immunoreactivity and mutation of the p53 gene in smooth muscle tumours of the uterine corpus. J Pathol 1995 177 : 65 70.
24. Niemann TH, Raab SS, Lenel JC, Rodgers JR, Robinson RA. p53 protein overexpression in smooth muscle tumors of the uterus. Hum Pathol 1995 26 : 375 379.
25. Amada S, Nakano H, Tsuneyoshi M. Leiomyosarcoma versus bizarre and cellular leiomyomas of the uterus: A comparative study based on the MIB-1 and proliferating cell nuclear antigen indices, p53 expression, DNA flow cytometry, and muscle specific actins. Int J Gynecol Pathol 1995 14 : 134 142.
26. Blom R, Guerrieri C, Stâl O, Malmström H, Simonsen E. Leiomyosarcoma of the uterus: A clinicopathologic, DNA flow cytometric, p53, and mdm-2 analysis of 49 cases. Gynecol Oncol 1998 68 : 54 61.
27. Zhai YL, Kobayashi Y, Mori A et al. Expression of steroid receptors, Ki-67, and p53 in uterine leiomyosarcomas. Int J Gynecol Pathol 1999 18 : 20 28.
28. Layfield LJ, Liu K, Dodge R, Barsky SH. Uterine smooth muscle tumors: Utility of classification by proliferation, ploidy, and prognostic markers versus traditional histopathology. Arch Pathol Lab Med 2000 124 : 221 227.
29. Mittal K, Demopoulos RI. MIB-1 (Ki-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tumors. Hum Pathol 2001 32 : 984 987.
30. Gökaslan H, Türkeri L, Kavak ZN et al. Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors. Gynecol Obstet Invest 2005 59 : 36 40.
31. Akhan SE, Yavuz E, Tecer A et al. The expression of Ki-67, p53, estrogen and progesterone receptors affecting survival in uterine leiomyosarcomas. A clinicopathologic study. Gynecol Oncol 2005 99 : 36 42.