Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats

Plant Foods for Human Nutrition

Volumn 65, Issue 2, 2010, Pages 91-98

  Udayakumar, Rajangam ^a   Kasthurirengan, Sampath ^b   Vasudevan, Ayyappan ^b   Mariashibu, Thankaraj Salammal ^b   Rayan, Jesudass Joseph Sahaya ^b   Choi, Chang Won ^a   Ganapathi, Andy ^b   Kim, Sei Chang ^a  

^a PaiChai University   (South Korea)

^b BHARATHIDASAN UNIVERSITY   (India)

Author keywords

Alloxan; Antioxidants; Diabetic rats; Free radicals; Phenolic compounds; Withania somnifera

Indexed keywords

ANTIDIABETIC AGENT; ANTIOXIDANT; FLAVONOID; GLIBENCLAMIDE; GLYCOGEN; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; DIET SUPPLEMENTATION; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; PHYTOTHERAPY; PLANT LEAF; PLANT ROOT; RAT; WISTAR RAT; WITHANIA;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; FLAVONOIDS; GLYBURIDE; GLYCOGEN; HYPOGLYCEMIC AGENTS; MALE; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES; WITHANIA;

RATTUS; WITHANIA SOMNIFERA;

EID: 77953327049     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-009-0146-8     Document Type: Article

References (35)

1. Li WL, Zheng HC, Bukuru J, De Kimpe N (2004) Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 92: 1-21.
2. Sutharson L, Hariharan RS, Vamsadhara C (2003) Drug utilization study in diabetology outpatient setting of a tertiary hospital. Ind J Pharmacol 35: 237-240.
3. Gallán PM, Carrascosa A, Gussinyé M, Dominguez C (2003) Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications. Free Radic Biol Med 34: 1563-1574.
4. Kharrazi H, Vaisi-Raygani A, Rahimi Z, Tavilani H, Aminian M, Pourmotabbed T (2008) Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease. Clin Biochem 41: 932-936.
5. Saito K, Kohno M, Yoshizaki F, Niwano Y (2008) Extensive screening for edible herbal extracts with potent scavenging activity against superoxide anions. Plant Foods Hum Nutr 63: 65-70.
6. Buyukbalci A, El SN (2008) Determination of in vitro antidiabetic effects, antioxidant activities and phenol contents of some herbal teas. Plant Foods Hum Nutr 63: 27-33.
7. Facciola S (1990) Cornucopia - A Source Book of Edible Plants. Kampong Publications, Vista.
8. Chopra RN, Nayar SL, Chopra IC (1986) Glossary of indian medicinal plants (including the supplement). Council of Scientific and Industrial Research, New Delhi.
9. Budhiraja RD, Sudhir S (1987) Review of biological activity of withanolides. J Sci Ind Res 46: 488-491.
10. Udayakumar R, Kasthurirengan S, Mariashibu TS, Rajesh M, Ramesh Anbazhagan V, Kim SC, Ganapathi A, Choi CW (2009) Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats. Int J Mol Sci 10: 2367-2382.
11. Singleton VL, Orthofer R, Lamuela-Raventos RM (1999) Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299: 152-178.
12. Quettier-Deleu C, Gressier B, Vasseur J, Dine T, Brunet C, Luyckx M, Cazin M, Cazin JC, Bailleul F, Trotin F (2000) Phenolic compounds and antioxidant activities of buckweat hulls and flour. J Ethnopharmacol 72: 35-42.
13. Chaudhry J, Ghosh NN, Roy K, Chandra R (2007) Antihyperglycaemic effect of a new thiazolidinedione analogue and its role in ameliorating oxidative stress in alloxan-induced diabetic rats. Life Sci 80: 1135-1142.
14. Varley H (2003) Practical Clinical Biochemistry. CBS Publishers and Distributors, New Delhi.
15. Sasaki T, Matsy S, Sonae A (1972) Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation. Rinsho Kagaku 1: 346-353.
16. Morales MA, Jabbagy AJ, Terenizi HR (1937) Mutations affecting accumulation of glycogen. Neurospora News 20: 24.
17. Roe JH, Kuether CA (1943) The determination of ascorbic acid in whole blood and urine through the 2, 4 dinitrophenyl hydrazine derivatives of dehydroascorbic acid. J Biol Chem 147: 2399.
18. Baker H, Frank O, De Angeles B, Feinglod S (1980) Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Rep Int 21: 531.
19. Kakkar P, Dos B, Viswanathan PN (1984) A modified spectrophotometric assay of superoxide dismutase. Ind J Biochem Biophys 21: 130-132.
20. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358.
21. Sinha AK (1972) Calorimetric assay of catalase. Anal Biochem 47: 389.
22. Rotruck CT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstara WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179: 588-590.
23. Habig WH, Pabst MJ, Jakoby WR (1977) Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
24. Beutler E, Duron O, Kelley BM (1937) Improved method for the determination of blood glutathione. J Lab Clin Med 61: 882-888.
25. Mishra LC, Singh BB, Dagenais S (2000) Scientific basis for the therapeutic use of Withania somnifera (Aswagandha): a review. Altern Med Rev 5: 334-346.
26. Kanitkar M, Bhonde R (2004) Existence of islet regenerating factors within the pancreas. Rev Diabetic Stud 32: 185-192.
27. Tang L-Q, Wei W, Chen L-M, Liu S (2006) Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharm 108: 109-115.
28. Mohan K, Das UN (2001) Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids. Nutrition 17: 126-151.
29. Panneerselvam SR, Govindasamy S (2004) Effect of sodium molybdate on the status of lipids, lipid peroxidation and antioxidant systems in alloxan-induced diabetic rats. Clin Chim Acta 345: 93-98.
30. Ananthan R, Latha M, Ramkumar KM, Pari L, Baskar C, Narmatha Bai V (2004) Modulatory effects of Gymnema montanum leaf extract on alloxan-induced oxidative stress in wistar rats. Nutrition 20: 280-285.
31. Tripathy AK, Dey S, Singh RH, Dey PK (1998) Alterations in the sensitivity of 5th receptor subtypes following chronic Withania somnifera (Aswagandha) treatment in rats. Anc Sci Life 17: 168-181.
32. Sozmen EY, Sozmen B, Delen Y, Onat T (2001) Catalase/superoxide dismutase (SOD) and catalase/paraoxonase (PON) ratios may implicate poor glycemic control. Arch Med Res 32: 283-287.
33. Rodriguez C, Mayo JC, Sainz RM, Antolín I, Herrera F, Martín V, Reiter RJ (2004) Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 36: 1-9.
34. Frei B, England L, Ames BN (1986) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86: 6377-6381.
35. Inefers H, Sies H (1988) The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. Eur J Biochem 174: 353-357.