Myocardial imaging with 99mTc-Tetrofosmin: Influence of post-stress acquisition time, regional radiotracer uptake, and wall motion abnormalities on the clinical result

Journal of Nuclear Cardiology

Volumn 17, Issue 2, 2010, Pages 276-285

  Giorgetti, Assuero ^a   Kusch, Annette ^a   Casagranda, Mirta ^a   Tagliavia, Irene D'Aragona ^a   Marzullo, Paolo ^a  

^a CNR   (Italy)

Author keywords

Gated SPECT; Myocardial perfusion imaging: SPECT; Partial volume effect; Tetrofosmin

Indexed keywords

TETROFOSMIN TC 99M; DIAGNOSTIC AGENT; ORGANOPHOSPHORUS COMPOUND; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M 1,2 BIS(BIS(2 ETHOXYETHYL)PHOSPHINO)ETHANE; TECHNETIUM TC 99M 1,2-BIS(BIS(2-ETHOXYETHYL)PHOSPHINO)ETHANE;

ADULT; ARTICLE; CARDIAC GATED IMAGING; CONTROLLED STUDY; FEMALE; HEART CONTRACTION; HEART FUNCTION; HEART HYPERTROPHY; HEART MOVEMENT; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; AGED; ANGIOCARDIOGRAPHY; CORONARY ARTERY DISEASE; HEART; HEART MUSCLE; METHODOLOGY; MIDDLE AGED; MOTION; PATHOLOGY; RADIOGRAPHY; SCINTISCANNING;

ADULT; AGED; AGED, 80 AND OVER; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HEART; HUMANS; MALE; MIDDLE AGED; MOTION; MYOCARDIUM; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 77953321359     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12350-009-9172-z     Document Type: Article

References (27)

1. Giorgetti A, Rossi M, Stanislao M, Valle G, Bertolaccini P, Maneschi A, et al. Feasibility and diagnostic accuracy of a gated SPECT early-imaging protocol: A multicenter study of the Myoview Imaging Optimization Group. J Nucl Med 2007;48:1670-5.
2. Jain D, Wackers FJT, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of technetium-99 m-tetrofosmin myocardial perfusion imaging agent: Implication for one-day imaging protocol. J Nucl Med 1993;34:1254-9.
3. Higley B, Smith FW, Smith T. Technetium-99 m-l, 2 bis (bis(2-ethoxyethyl) phosphino) ethane: Human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med 1993;34:30-8.
4. Germano G, Bermann DS. Clinical gated cardiac SPECT. Armhonk (NY): Futura Publishing; 1999.
5. Ficaro EP, Lee BC, Kritzman JN. Corbett JR Corridor4DM: The Michigan method for quantitative nuclear cardiology. J Nucl Cardiol 2007;14:455-6.
6. Germano G, Erel J, Lewin H, et al. Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 1997;30: 1360-7.
7. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical assessment. Lancet 1986;1:307-10.
8. Hamilton C, Stamey J. Using Bland-Altman to assess agreement between two medical devices - don't forget the confidence intervals!. J Clin Monit Comput 2007;21:331-3.
9. Rigo P, Leclercq B, Itti R, Lahiri A, Braat S. Technetium-99m tetrofosmin myocardial imaging: A comparison with thallium-201 and angiography. J Nucl Med 1994;35:587-93.
10. Sullo P, Cuocolo A, Nicolai E, Cardei S, Nappi A, Squame F, et al. Quantitative exercise technetium-99m tetrofosmin myocardial tomography for the identification and localization of coronary artery disease. Eur J Nucl Med 1996;23:648-55.
11. Acampa W, Cuocolo A, Petretta M, Bruno A, Castellani M, Finzi A, et al. Tetrofosmin imaging in the detection of myocardial viability in patients with previous myocardial infarction: Comparison with sestamibi and Tl-201 scintigraphy. J Nucl Cardiol 2002;9:33-40.
12. Giorgetti A, Marzullo P, Sambuceti G, Di Quirico S, Kusch A, Landi P, et al. Baseline/post-nitrate 99mTc-tetrofosmin mismatch for the assessment of myocardial viability in patients with severe left ventricular dysfunction: Comparison with baseline 99mTc-tetrofosmin scintigraphy/18FDG-positron emission tomography imaging. J Nucl Cardiol 2004;11:142-51.
13. Platts EA, North Tl, Pickett RD, Kelly JD. Mechanism of technetium-tetrofosmin I: Uptake into isolated adult rat ventricular myocytes and subcellular localization. J Nucl Cardiol 1995;2:317-26.
14. Okada DR, Liu Z, Beju D, Okada RD, Johnson G III. Monocationic radiotracer kinetics and myocardial infarct size: A perfused rat heart study. Ann Nucl Med 2008;22:617-27.
15. Schulz G, Ostwald E, Kaiser HJ, wom Dahl J, Kleinhans E, Buell E. Cardiac stress-rest single-photon emission computed tomography with technetium 99m-labeled tetrofosmin: Influence of washout kinetics on regional myocardial uptake values of the rest study with a 1-day protocol. J Nucl Cardiol 1997;4:298-301.
16. Ito Y, Uehara T, Fukuchi K, Tsujimura E, Hasegawa S, Nishimura T. Comparison of dual-isotope acquisition of 201Tl and 99Tcm-tetrofosmin for the detection of ischaemic heart disease and determination of the optimal imaging time of 99Tcm-tetrofosmin. Nucl Med Commun 1998;19:119-26.
17. Younes A, Songadele JA, Maublant J, Platts E, Pickett R, Veyre A. Mechanism of uptake of technetium-tetrofosmin. II: Uptake into isolated adult rat heart mitochondria. J Nucl Cardiol 1995;2:327-33.
18. Bolli R, Marban E. Molecular and cellular mechanisms of myocardial stunning. Physiol Rev 1999;79:609-34.
19. Ambrosio G, Betocchi S, Pace L, Losi MA, Perrone-Filardi P, Soricelli A, et al. Prolonged impairment of regional contractile function after resolution of exercise-induce angina: Evidence of myocardial stunning in patients with coronary artery disease. Circulation 1996;94:2455-66.
20. Toba M, Kumita S, Cho K, Ibuki C, Kumazaki T, Takano T. Usefulness of gated myocardial perfusion SPECT imaging soon after exercise to identify postexercise stunning in patients with single-vessel coronary artery disease. J Nucl Cardiol 2004;11:697-703.
21. Paul AK, Hasegawa S, Yoshioka J, Mu X, Maruyama K, Kusuoka H, et al. Characteristics of regional myocardial stunning after exercise in gated myocardial SPECT. J Nucl Cardiol 2002;9:388-94.
22. Lee DS, Yeo JS, Chung JK, Lee MM, Lee MC. Transient prolonged stunning induced by dipyridamole and shown on 1- and 24-hour poststress 99mTc-MIBI gated SPECT. J Nucl Med 2000;41:27-35.
23. Dakik HA, Alam S. Myocardial stunning induced and detected by adenosine stress perfusion imaging. J Nucl Cardiol 2001;8:711-2.
24. Kaufmann BA, Pfisterer ME, Viswanathan S, Muller-Brand J, Zellweger MJ. Stunning and left ventricular function - How long is the ventricle knocked out? Left ventricular function correlated with ischemic burden and recovery time after stress. Int J Cardiol 2006;112:223-8.
25. Ward RP, Gundeck EL, Lang RM, Spencer KT, Williams KA. Overestimation of postischemic myocardial stunning on gated SPECT imaging: Correlation with echocardiography. J Nucl Cardiol 2006;13:514-20.
26. Parodi O, Schelbert HR, Schwaiger M, Hansen H, Selin C, Hoffman EJ. Cardiac emission computed tomography: Underestimation of regional tracer concentrations due to wall motion abnormalities. J Comput Assist Tomogr 1984;8:1083-90.
27. Sinusas AJ, Shi Q, Vitolis PJ, Fetterman RC, Maniawski P, Zaret BL, et al. Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-Sestamibi defect size. Circulation 1993;88:2224-34.