Dysregulated Th1 and Th2 responses in food-allergic children - Does elimination diet contribute to the dysregulation?

Pediatric Allergy and Immunology

Volumn 21, Issue 4 PART 1, 2010, Pages 649-655

  Tomičić, Sara ^a   Fälth Magnusson, Karin ^a   Böttcher, Malin Fageras ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Children; Cytokines; Elimination diet; Food allergy; Tolerance

Indexed keywords

BETA LACTOGLOBULIN; EMOLLIENT AGENT; FOOD ALLERGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; PLACEBO; STEROID; TETANUS TOXOID;

ARTICLE; CELL ISOLATION; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; ECZEMA; EGG ALLERGY; ENZYME LINKED IMMUNOSORBENT ASSAY; GROUPS BY AGE; HUMAN; HUMAN CELL CULTURE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFANT; MILK ALKALI SYNDROME; MILK ALLERGY; MULTICENTER STUDY; NUTRITIONAL INTOLERANCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TH1 CELL; TH2 CELL;

ALLERGENS; ANIMALS; CELLS, CULTURED; CHILD, PRESCHOOL; CYTOKINES; ECZEMA; EGGS; FEMALE; FOLLOW-UP STUDIES; FOOD HABITS; FOOD HYPERSENSITIVITY; HUMANS; IMMUNE TOLERANCE; INFANT; LACTOGLOBULINS; LEUKOCYTES, MONONUCLEAR; MALE; MILK; PROSPECTIVE STUDIES; TH1-TH2 BALANCE;

EID: 77953299441     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2009.00937.x     Document Type: Article

References (29)

1. Björkstén B. The intrauterine and postnatal environments. J Allergy Clin Immunol 1999 : 104 : 1119 1127.
2. Hattevig G, Kjellman B, Björkstén B. Appearance of IgE antibodies to ingested and inhaled allergens during the first 12 years of life in atopic and non-atopic children. Pediatr Allergy Immunol 1993 : 4 : 182 186.
3. Yang L-P, Byun D-G, Demeure CE, Vezzio N, Delespesse G. Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells. Eur J Immunol 1995 : 25 : 3517 3520.
4. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today 1993 : 14 : 353 356.
5. Jenmalm MC, Van Snick J, Cormont F, Salman B. Allergen-induced Th1 and Th2 secretion in relation to specific allergen sensitization and atopic symptoms in children. Clin Exp Allergy 2001 : 31 : 1528 1535.
6. Imada M, Estelle F, Simons R, Jay FT, HayGlass KT. Allergen-stimulated interleukon-4 and interferon-γ production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunology 1995 : 85 : 373 380.
7. Macaubas C, Sly PD, Burton PR, et al. Regulation of T-helper cell responses to inhalant allergen during early childhood. Clin Exp Allergy 1999 : 29 : 1223 1231.
8. Sampson HA, McCaskill CC. Food hypersensitivity and atopic dermatitis: evaluation of 113 patients. J Pediatr 1985 : 107 : 669 675.
9. Bruijnzeel-Koomen C, Ortolani C, Aas K, et al. Adverse reactions to food. Eur Acad Allergol Clin Immunol 1995 : 50 : 623 635.
10. Dannaeus A, Inganäs M. A follow-up study of children with food allergy. Clinical course in relation to serum IgE- and IgG-antibody levels to milk, egg and fish. Clin Allergy 1981 : 11 : 533 539.
11. Schade RP, Van leperen-Van Dijk AG, Van Reijsen FC, et al. Differences in antigen-specific T-cell responses between infants with atopic dermatitis with and without cow's milk allergy: relevance of Th2 cytokines. J Allergy Clin Immunol 2000 : 106 : 1155 1162.
12. Noma T, Yoshizawa I, Aoki K, Yamaguchi K, Baba M. Cytokine production in children outgrowing hen egg allergy. Clin Exp Allergy 1996 : 26 : 1298 1307.
13. Norrman G, Tomičić S, Böttcher MF, Oldaeus G, Strömberg L, Fälth-Magnusson K. Significant improvement of eczema with skin care and food elimination in small children. Acta Paediatr 2005 : 94 : 1384 1388.
14. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980 : 92 : 44 7.
15. Consensus report of the European Task Force on Atopic dermatitis. Severity scoring of atopic dermatitis: the SCORAD index. Dermatology 1993 : 186 : 23 31.
16. Devenney I, Norrman G, Oldaeus G, Strömberg L, Fälth-Magnusson K. A new model for low-dose food challenge in children with allergy to milk or egg. Acta Paediatr 2006 : 95 : 1133 1139.
17. Schade RP, Van leperen-Van Dijk AG, Versluis C, et al. Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy. J Allergy Clin Immunol 2002 : 109 : 357 362.
18. Karlsson MR, Kahu LA, Hanson LA, Telemo E, Dahlgren UI. Tolerance and bystander suppression, with involvement of CD25-positive cells, is induced in rats receiving serum from ovalbumin-fed donors. Immunology 2000 : 100 : 326 333.
19. Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005 : 116 : 961 968.
20. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4 + CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004 : 199 : 1679 1688.
21. Hesselmar B, Åberg N, Åberg B, Eriksson B, Björkstén B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999 : 29 : 611 617.
22. Perzanowski MS, Rönmark E, Platts-Mills TA, Lundbäck B. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 2002 : 166 : 696 702.
23. Nouria-Aria KT, Francis JN, Jacobson MR, et al. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 2004 : 175 : 3252 3259.
24. Akbari O, Freeman GJ, Meyer EH, et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002 : 8 : 1024 1032.
25. Bohle B, Kinaciyan T, Gerstmayr M, Radkovics A, Jahn-Schmid B, Ebner C. Sublingual immunotherapy induces IL10 producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 2007 : 120 : 707 713.
26. Flinterman AE, Knulst A, Meijer Y, Bruijnzeel-Koomen CAFM. Acute allergic reactions in children with AEDS after prolonged cow's milk elimination diets. Allergy 2006 : 61 : 370 374.
27. Niggemann B, Staden U, Rolinck-Werninghaus C, Beyer K. Specific oral tolerance induction in food allergy. Allergy 2006 : 61 : 808 811. (Pubitemid 43893982)
28. Buchanan AD, Green TD, Jones SM, et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007 : 119 : 199 205.
29. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008 : 121 : 343 347.