Can non-performance of radical systematic mediastinal lymphadenectomy be justified in elderly lung cancer patients? An evaluation using propensity-based survival analysis

European Journal of Cardio-thoracic Surgery

Volumn 38, Issue 1, 2010, Pages 27-33

  Okasaka, Toshiki ^a,b   Usami, Noriyasu ^a   Taniguchi, Tetsuo ^a   Kawaguchi, Koji ^a   Okagawa, Takehiko ^a   Suzuki, Haruko ^a   Matsuo, Keitaro ^b   Yokoi, Kohei ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Elderly patients; Lung cancer; Lymph node dissection

Indexed keywords

AGED; ARTICLE; CANCER SURGERY; FEMALE; GERIATRIC PATIENT; HUMAN; KAPLAN MEIER METHOD; LUNG CANCER; LUNG LOBECTOMY; LUNG NON SMALL CELL CANCER; LUNG RESECTION; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; MEDIASTINUM LYMPH NODE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROPENSITY BASED ANALYSIS; PROPORTIONAL HAZARDS MODEL; SCORING SYSTEM; STATISTICAL ANALYSIS; SURVIVAL RATE; TREATMENT INDICATION; TREATMENT OUTCOME;

AGE FACTORS; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPH NODE EXCISION; MALE; MEDIASTINUM; NEOPLASM STAGING; TREATMENT OUTCOME; UNNECESSARY PROCEDURES;

EID: 77953292120     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2010.01.017     Document Type: Article

References (22)

1. Matsuda T., Marugame T., Kamo K., Katanoda K., Ajiki W., and Sobue T. Cancer incidence and incidence rates in Japan in 2002: based on data from 11 population-based cancer registries. Jpn J Clin Oncol 38 (2008) 641-648
2. Aoki T., Yamato Y., Tsuchida M., Watanabe T., Hayashi J., and Hirono T. Pulmonary complications after surgical treatment of lung cancer in octogenarians. Eur J Cardiothorac Surg 18 (2000) 662-665
3. Birim O., Zuydendorp H.M., Maat A.P., Kappetein A.P., Eijkemans M.J., and Bogers A.J. Lung resection for non-small-cell lung cancer in patients older than 70: mortality, morbidity, and late survival compared with the general population. Ann Thorac Surg 76 (2003) 1796-1801
4. Port J.L., Kent M., Korst R.J., Lee P.C., Levin M.A., Flieder D., and Altorki N.K. Surgical resection for lung cancer in the octogenarian. Chest 126 (2004) 733-738
5. Matsuoka H., Okada M., Sakamoto T., and Tsubota N. Complications and outcomes after pulmonary resection for cancer in patients 80 to 89 years of age. Eur J Cardiothorac Surg 28 (2005) 380-383
6. Brock M.V., Kim M.P., Hooker C.M., Alberg A.J., Jordan M.M., Roig C.M., Xu L., and Yang S.C. Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience. Ann Thorac Surg 77 (2004) 271-277
7. Naruke T., Goya T., Tsuchiya R., and Suemasu K. The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis. Ann Thorac Surg 46 (1988) 603-610
8. Martini N., Flehinger B.J., Zaman M.B., and Beattie Jr. E.J. Results of resection in non-oat cell carcinoma of the lung with mediastinal lymph node metastases. Ann Surg 198 (1983) 386-397
9. Izbicki J.R., Passlick B., Pantel K., Pichlmeier U., Hosch S.B., Karg O., and Thetter O. Effectiveness of radical systematic mediastinal lymphadenectomy in patients with resectable non-small cell lung cancer: results of a prospective randomized trial. Ann Surg 227 (1998) 138-144
10. Wu Y., Huang Z.F., Wang S.Y., Yang X.N., and Ou W. A randomized trial of systematic nodal dissection in resectable non-small cell lung cancer. Lung Cancer 36 (2002) 1-6
11. Okada M., Sakamoto T., Yuki T., Mimura T., Miyoshi K., and Tsubota N. Selective mediastinal lymphadenectomy for clinico-surgical stage I non-small cell lung cancer. Ann Thorac Surg 81 (2006) 1028-1032
12. Chida M., Minowa M., Karube Y., Eba S., Okada Y., Miyoshi S., and Kondo T. Worsened long-term outcomes and postoperative complications in octogenarians with lung cancer following mediastinal lymph-node dissection. Interact Cardiovasc Thorac Surg 8 (2009) 89-92
13. Naruke T., Suemasu K., and Ishikawa S. Surgical treatment for lung cancer with metastasis to mediastinal lymph nodes. J Thorac Cardiovasc Surg 71 (1976) 279-285
14. Rosenbaum P.R., and Rubin D.B. Reducing bias in observational studies using subclassification on the propensity score. J Am Stat Assoc 79 (1984) 516-524
15. StataCorp. STATA for Windows: version 10. College Station: StataCorp; 2007.
16. Massard G., Ducrocq X., Kochetkova E.A., Porhanov V.A., and Riquet M. Sampling or node dissection for intraoperative staging of lung cancer: a multicentric cross-sectional study. Eur J Cardiothorac Surg 30 (2006) 164-167
17. Doddoli C., Aragon A., Barlesi F., Chetaille B., Robitail S., Giudicelli R., Fuentes P., and Thomas P. Does the extent of lymph node dissection influence outcome in patients with stage I non-small-cell lung cancer?. Eur J Cardiothorac Surg 27 (2005) 680-685
18. Ma K., Chang D., He B., Gong M., Tian F., Hu X., Ji Z., and Wang T. Radical systematic mediastinal lymphadenectomy versus mediastinal lymph node sampling in patients with clinical stage IA and pathological stage T1 non-small cell lung cancer. J Cancer Res Clin Oncol 134 (2008) 1289-1295
19. Takizawa H., Kondo K., Matsuoka H., Uyama K., Toba H., Kenzaki K., Sakiyama S., Tangoku A., Miura K., Yoshizawa K., and Morita J. Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer. J Med Invest 55 (2008) 37-43
20. Varlotto J.M., Recht A., Nikolov M., Flickinger J.C., and Decamp M.M. Extent of lymphadenectomy and outcome for patients with stage I nonsmall cell lung cancer. Cancer 115 (2009) 851-858
21. Ishiguro F, Matsuo K, Fukui T, Mori S, Hatooka S, Mitsudomi T. Effect of selective lymph node dissection based on patterns of lobe-specific lymph node metastases on patient outcome in patients with resectable non-small cell lung cancer: a large-scale retrospective cohort study applying a propensity score. J Thorac Cardiovasc Surg, in press.
22. Aoki T., Tsuchida M., Watanabe T., Hashimoto T., Koike T., Hirono T., and Hayashi J. Surgical strategy for clinical stage I non-small cell lung cancer in octogenarians. Eur J Cardiothorac Surg 23 (2003) 446-450