Assessment of DNA methylation at the interferon regulatory factor 5 (IRF5) promoter region in inflammatory bowel diseases

International Journal of Colorectal Disease

Volumn 25, Issue 5, 2010, Pages 553-556

  Balasa, Alfred ^a   Gathungu, Grace ^b   Kisfali, Peter ^c   O'Brian Smith, E ^d   Cho, Judy H ^b   Melegh, Bela ^c   Kellermayer, Richard ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

^d CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

DNA methylation; Inflammatory bowel diseases; IRF5; Polymorphism

Indexed keywords

DNA; INTERFERON REGULATORY FACTOR 5;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; CROHN DISEASE; DNA METHYLATION; EPIGENETICS; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; INDEL MUTATION; LEUKOCYTE; MALE; PRIORITY JOURNAL; PROMOTER REGION; ULCERATIVE COLITIS;

ADULT; CPG ISLANDS; DNA METHYLATION; FEMALE; HUMANS; INDEL MUTATION; INFLAMMATORY BOWEL DISEASES; INTERFERON REGULATORY FACTORS; MALE; PROMOTER REGIONS, GENETIC;

EID: 77953290791     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-010-0874-0     Document Type: Article

References (23)

1. Reik W (2007) Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447:425-432
2. Robertson KD (2005) DNA methylation and human disease. Nat Rev Genet 6:597-610
3. Kerkel K, Spadola A, Yuan E et al (2008) Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet 40:904-908
4. Ligtenberg MJ, Kuiper RP, Chan TL et al (2009) Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1. Nat Genet 41:112-117
5. Moser D, Ekawardhani S, Kumsta R et al (2009) Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site. Neuropsychopharmacology 34:458-467
6. Wang H, Ogawa M, Wood JR et al (2008) Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes. Hum Mol Genet 17:1087-1096
7. Loftus EV Jr (2004) Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 126:1504-1517
8. Sathiyasekaran M, Shivbalan S (2006) Crohn's disease. Indian J Pediatr 73:723-729
9. Petronis A (2006) Epigenetics and twins: three variations on the theme. Trends Genet 22:347-350
10. Biank V, Broeckel U, Kugathasan S (2007) Pediatric inflammatory bowel disease: clinical and molecular genetics. Inflamm Bowel Dis 13:1430-1438
11. Petronis A, Petroniene R (2000) Epigenetics of inflammatory bowel disease. Gut 47:302-306
12. Tahara T, Shibata T, Nakamura M et al (2009) Effect of MDR1 gene promoter methylation in patients with ulcerative colitis. Int J Mol Med 23:521-527
13. Tahara T, Shibata T, Nakamura M et al (2009) Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC). Clin Exp Med 9:125-130
14. Dideberg V, Kristjansdottir G, Milani L et al (2007) An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Hum Mol Genet 16:3008-3016
15. Sigurdsson S, Goring HH, Kristjansdottir G et al (2008) Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Hum Mol Genet 17:872-881
16. Brandeis M, Frank D, Keshet I et al (1994) Sp1 elements protect a CpG island from de novo methylation. Nature 371:435-438
17. Magyari L, Farago B, Bene J et al (2007) No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples. World J Gastroenterol 13:2205-2208
18. Waterland RA, Jirtle RL (2003) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23:5293-5300
19. Shen L, Guo Y, Chen X, Ahmed S, Issa JP (2007) Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis. Biotechniques 42:48-52
20. Colella S, Shen L, Baggerly KA, Issa JP, Krahe R (2003) Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites. Biotechniques 35:146-150
21. Bock C, Walter J, Paulsen M, Lengauer T (2008) Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping. Nucleic Acids Res 36:e55
22. Mikeska T, Bock C, El-Maarri O et al (2007) Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J Mol Diagnostics 9:368-381
23. Gazzoli I, Kolodner RD (2003) Regulation of the human MSH6 gene by the Sp1 transcription factor and alteration of promoter activity and expression by polymorphisms. Mol Cell Biol 23: 7992-8007