Anticonvulsant effects of Searsia dentata (anacardiaceae) leaf extract in rats

Phytotherapy Research

Volumn 24, Issue 6, 2010, Pages 924-927

  Pedersen, Mikael E ^a,b,c   Baldwin, Roger A ^c   Niquet, Jerome ^c   Stafford, Gary I ^b   Van Staden, Johannes ^b   Wasterlain, Claude G ^c   Jäger, Anna K ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Epilepsy; NMDA receptor antagonists; Traditional medicine

Indexed keywords

ALCOHOL; BICUCULLINE; DIAZEPAM; N METHYL DEXTRO ASPARTIC ACID; PENTETRAZOLE; PLANT EXTRACT; SEARSIA DENTATA EXTRACT; UNCLASSIFIED DRUG;

ANACARDIACEAE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; EPILEPSY; MALE; MEDICINAL PLANT; NONHUMAN; PERINATAL PERIOD; PLANT LEAF; RAT; SEIZURE; WISTAR RAT;

ANACARDIACEAE; ANIMALS; ANTICONVULSANTS; BICUCULLINE; DISEASE MODELS, ANIMAL; EPILEPSY; KAINIC ACID; MALE; N-METHYLASPARTATE; PENTYLENETETRAZOLE; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES;

ANACARDIACEAE; ANIMALIA; RATTUS; SEARSIA (ANGIOSPERM);

EID: 77953271481     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3016     Document Type: Article

References (11)

1. Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. 2000. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 59: 1387-1394.
2. Gottlieb A, Keydar I, Epstain HT. 1977. Rodent brain growth stages: an analytical review. Biol Neonat 32: 166-76.
3. Lee J-H, Kim S-R, Bae C-S, Hong H-N, Nah S-Y. 2002. Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus. Neurosci Lett 325: 129-133.
4. Ojewole JAO. 2008. Anticonvulsant effect of Rhus chirindensis (Baker F.) (Anacardiaceae) stem-bark aqueous extract in mice. J Ethnopharmacol 117: 130-135.
5. Pedersen ME, Vestergaard HT, Stafford GI, Van Staden J, Jäger AK. 2008. The effect of extracts of Searsia species on epileptiform activity in slices of the mouse cerebral cortex. J Ethnopharmacol 119: 538-541.
6. Racine RJ. 1972. Modification of seizure activity by electrical brain stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32: 281-294.
7. Rang HP, Dale MM, Ritter JM, Moore PK. 2007. Pharmacology (6th edn). Churchill Livingstone: Edinburgh.
8. Schwartzkroin PA, Moshe SL, Noebels JL, Swann JW. 1995. Brain development and epilepsy. Oxford University Press: New York.
9. Stafford GI, Pedersen ME, Van Staden J, Jäger AK. 2008. Review on plants with CNS-effects used in traditional South African medicine against mental diseases. J Ethnopharmacol 119: 513-537.
10. Svenningsen AB, Madsen KD, Liljefors T, Stafford GI, Van Staden J, Jäger AK. 2006. Biflavones from Rhus species with affinity for the GABAA/benzodiazepine receptor. J Ethnopharmacol 103: 276-280.
11. Velísek L. 2006. Models of chemically induced acute seizures. In Models of Seizures and Epilepsy, Pitkänen A, Schwartzkroin PA, Solomon LM (eds). Elsevier Academic Press: San Diego, California, USA; 127-152.