Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials

Alzheimer Disease and Associated Disorders

Volumn 24, Issue 2, 2010, Pages 165-170

  Carr, Sarah A ^a,b   Davis, Roberta ^a,b   Spencer, Diane ^a,b   Smart, Marie ^a,b   Hudson, Joanna ^a,b   Freeman, Stephanie ^a,b   Cooper, Greg E ^a,b   Schmitt, Fred A ^a,b   Markesbery, William R ^a,b,c   Danner, Deborah ^a,b,c   Jicha, Gregory A ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Department of Pathology ^*  (United States)

Author keywords

Alzheimer disease; Clinical trial; Recruitment

Indexed keywords

ADULT; ALZHEIMER DISEASE; ARTICLE; COMMUNITY CARE; CONTINUING EDUCATION; CONTROLLED STUDY; DOCTOR PATIENT RELATION; FEMALE; HEALTH PRACTITIONER; HUMAN; MALE; MEDICAL RESEARCH; NORMAL HUMAN; PATIENT PARTICIPATION; PHYSICIAN ATTITUDE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RESEARCH SUBJECT;

AGED; ALZHEIMER DISEASE; CLINICAL TRIALS AS TOPIC; COMMUNITY NETWORKS; COST-BENEFIT ANALYSIS; EDUCATION, MEDICAL, CONTINUING; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT SELECTION; PHYSICIANS, FAMILY;

EID: 77953271105     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e3181aba927     Document Type: Article

References (20)

1. Dowling GA, Wiener CL. Roadblocks encountered in recruiting patients for a study of sleep disruption in Alzheimer's disease. Image J Nurs Sch. 1997;29:59-64.
2. Hendrie HC. Lessons learned from international comparative crosscultural studies on dementia. Am J Geriatr Psychiatry. 2006;14:480-488.
3. Macias FM, Ramsay RE, Rowan AJ. Recruitment and retention in clinical trials of the elderly. Int Rev Neurobiol. 2007;81:265-272.
4. Schneider LS. Drug development, clinical trials, cultural heterogeneity in Alzheimer disease: the need for pro-active recruitment. Alzheimer Dis Assoc Disord. 2005;19:279-283.
5. Treves TA, Verchovsky R, Klimovitsky S, et al. Recruitment rate to drug trials for dementia of the Alzheimer type. Alzheimer Dis Assoc Disord. 2000;14:209-211.
6. Wrobel AJ, Shapiro NE. Conducting research with urban elders: issues of recruitment, data collection, and home visits. Alzheimer Dis Assoc Disord. 1999;13(suppl 1):S34-S38.
7. Williams DE, Vitiello MV, Ries RK, et al. Successful recruitment of elderly community-dwelling subjects for Alzheimer's disease research. J Gerontol. 1988;43:M69-M74.
8. Campbell MK, Snowdon C, Francis D, et al. Recruitment to randomized trials: strategies for trial enrollment and participation study. The STEPS study. Health Technol Assess. 2007;11:iii, ix-105.
9. Chin Feman SP, Nguyen LT, Quilty MT, et al. Effectiveness of recruitment in clinical trials: an analysis of methods used in a trial for irritable bowel syndrome patients. Contemp Clin Trials. 2008;29:241-251.
10. Elley CR, Robertson MC, Kerse NM, et al. Falls Assessment Clinical Trial (FACT): design, interventions, recruitment strategies and participant characteristics. BMC Public Health. 2007;7:185.
11. Galbreath AD, Smith B, Wood P, et al. Cumulative recruitment experience in two large single-center randomized, controlled clinical trials. Contemp Clin Trials. 2008;29:335-342.
12. Hinshaw LB, Jackson SA, Chen MY. Direct mailing was a successful recruitment strategy for a lung-cancer screening trial. J Clin Epidemiol. 2007;60:853-857.
13. Peck LE, Sharpe PA, Burroughs EL, et al. Recruitment strategies and costs for a community-based physical activity program. Health Promot Pract. 2008;9:191-198.
14. Robins Sadler G, Olson LK, Krause AS, et al. Recruiting older women to research studies: the san diego cooperative mammography project. Breast Dis. 2001;13:33-40.
15. Shuhatovich OM, Sharman MP, Mirabal YN, et al. Participant recruitment and motivation for participation in optical technology for cervical cancer screening research trials. Gynecol Oncol. 2005;99(3 suppl 1):S226-S231.
16. Veenhof C, Dekker J, Bijlsma JW, et al. Influence of various recruitment strategies on the study population and outcome of a randomized controlled trial involving patients with osteoarthritis of the hip or knee. Arthritis Rheum. 2005;53:375-382.
17. Yancey AK, Ortega AN, Kumanyika SK. Effective recruitment and retention of minority research participants. Annu Rev Public Health. 2006;27:1-28.
18. Rahman M, Morita S, Fukui T, et al. Physicians' reasons for not entering their patients in a randomized controlled trial in Japan. Tohoku J Exp Med. 2004;203:105-109.
19. Ross S, Grant A, Counsell C, et al. Barriers to participation in randomized controlled trials: a systematic review. J Clin Epidemiol. 1999;52:1143-1156.
20. Taylor KM, Margolese RG, Soskolne CL. Physicians' reasons for not entering eligible patients in a randomized clinical trial of surgery for breast cancer. N Engl J Med. 1984;310:1363-1367.